Peer-reviewed studies using the EVOS M5000 Imaging System for cancer cell imaging, proliferation, apoptosis, genome editing and tumour models. Each entry was discovered independently of Thermo Fisher's curated EVOS M5000 citations and verified to mention the EVOS M5000 Imaging System as a microscope in the full text. Paper cards link to Google Scholar, PubMed, PMC and DOI when available.
Cell type: cell line, macrophage | Technique: knockout | Disease/area: cancer, inflammation | Nature communications (2025)
Tissue-resident macrophages (TRM) are critical for mammalian organismal development and homeostasis. Here we report that with-no-lysine 1 (WNK1) controls myeloid progenitor fate, with Csf1r
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Cell type: general | Technique: EdU proliferation | Disease/area: cancer | RSC advances (2025)
A novel series of mesitylene-based spirooxindoles were synthesized
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Cell type: cell line | Technique: general | Disease/area: cancer | Scientific reports (2025)
HER2 is a membrane receptor tyrosine kinase overexpressed in 18-20% of gastric tumors. Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) that targets HER2-positive (HER2
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Cell type: cell line | Technique: general | Disease/area: cancer | Inorganic chemistry (2025)
2-(4-dimethylaminophenyl)benzothiazolate (Me
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Cell type: cancer cell, cell line | Technique: CRISPR | Disease/area: cancer | Cell genomics (2025)
Chromosomal instability (CIN) drives tumor heterogeneity, complicating cancer therapy. Although Polo-like kinase 1 (PLK1) overexpression induces CIN, direct inhibition of PLK1 has shown limited clinical benefits. We therefore performed a genome-wide synthetic
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Cell type: T cell, cell line, fibroblast | Technique: general | Disease/area: cancer | Molecular cancer therapeutics (2025)
Lung cancer is the leading cause of cancer-related mortality worldwide. Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer and comprises 85% of cases. Despite treatment advances, local control after curative-intent chemoradiation for
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Cell type: cancer cell | Technique: general | Disease/area: cancer | Nutrients (2025)
(Abstract unavailable)
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Cell type: general | Technique: general | Disease/area: cancer | Pharmaceuticals (Basel, Switzerland) (2025)
(Abstract unavailable)
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Cell type: cell line | Technique: western blot | Disease/area: cancer | Molecular medicine reports (2025)
The present study aimed to investigate how sevoflurane (SEV) regulated the apoptosis of glioma cells through the mitochondrial apoptosis pathway. First, an evaluation was performed on the viability, apoptosis, mitochondrial reactive oxygen species levels, mito
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Cell type: general | Technique: general | Disease/area: cancer | iScience (2025)
Due to limited light penetration and dependence on oxygen, photodynamic therapy (PDT) is typically restricted to treating shallow tissues. Developing strategies to overcome these limitations and effectively using PDT for tumor treatment is a significant yet un
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Cell type: general | Technique: general | Disease/area: cancer | Cancers (2025)
(Abstract unavailable)
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Cell type: cell line | Technique: EdU proliferation, flow cytometry, western blot | Disease/area: cancer | Hereditas (2025)
E2F Transcription Factor 1 (E2F1) is a transcription factor that plays a crucial role in the growth of many cancers, including hepatocellular carcinoma (HCC). Herein, this study probed the functions and underlying mechanisms of E2F1 in HCC tumorigenesis. The e
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Cell type: cancer cell | Technique: general | Disease/area: cancer | Journal of cancer prevention (2025)
Chromosomal alterations are frequent events in lung cancer progression. Although gains and losses of chromosomal position have been reported, the association between copy number alteration and lung cancer patient survival has not been extensively investigated.
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Cell type: cancer cell, cell line | Technique: EdU proliferation | Disease/area: cancer | Journal for immunotherapy of cancer (2025)
Natural killer (NK) cells play a critical role in modulating immune responses by secreting soluble factors, including chemotactic cytokines. Our previous study demonstrated the potent antitumor activity of Chem_NK, referring to NK cells chemically primed with
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Cell type: general | Technique: EdU proliferation | Disease/area: cancer | Antioxidants (Basel, Switzerland) (2025)
Hepatocellular carcinoma (HCC) is the third most common cancer in terms of mortality and the sixth in incidence worldwide. Treatment varies by tumor stage, but low survival rates are common across all stages. Due to these poor outcomes, there is a critical nee
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Cell type: cancer cell, cell line | Technique: general | Disease/area: cancer | Cell death & disease (2025)
Ionising radiation causes the introduction of DNA damage, more specifically double strand breaks (DSBs) and complex DNA damage (CDD), that induces cancer cell death leading to the therapeutic effect. To combat this, cells activate arrest at the G
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Cell type: cancer cell, cell line | Technique: general | Disease/area: cancer | ACS nano (2025)
The mRNA-lipid nanoparticles (mRNA@LNPs) offer a novel opportunity to treat targets previously considered undruggable. Although antibody conjugation is crucial for enhancing the specificity, delivery efficiency, and minimizing the toxicity of mRNA therapeutics
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Cell type: cancer cell | Technique: knockout | Disease/area: cancer | Scientific reports (2025)
Platelets are enriched in miRNAs and harbor Ago2 as the principal RNA silencing Argonaute. However, roles in thrombopoiesis and platelet function remain poorly understood. We generated megakaryocyte/platelet-specific Ago2-deleted (Ago2 KO) mice and assessed pr
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Cell type: cell line | Technique: EdU proliferation | Disease/area: cancer | International journal of molecular sciences (2025)
Breast cancer treatment has advanced significantly, particularly for estrogen receptor-positive (ER+) tumors. Tamoxifen, an estrogen antagonist, is widely used; however, approximately 40% of patients develop resistance. Recent studies indicate that microRNAs,
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Cell type: general | Technique: CRISPR | Disease/area: cancer | Biology direct (2025)
Regeneration is the preferred approach to restore the structure and function after tissue damage. Rapid proliferation of cells over the site of damage is integral to the process of regeneration. However, even subtle mutations in proliferating cells may cause d
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Cell type: general | Technique: general | Disease/area: cancer | NPJ precision oncology (2025)
High-grade soft tissue sarcomas (STS) are a heterogeneous and aggressive set of cancers. Failure to respond anthracycline chemotherapy, standard first-line treatment, is associated with poor outcomes. We investigated the contribution of STS cancer stem cells (
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Cell type: general | Technique: general | Disease/area: cancer | Bioactive materials (2025)
Plant-derived extracellular vesicles (PEVs) have been regarded as a superior source for nanomedicine and drug delivery systems. Nevertheless, their clinical translation is hindered by the lack of clarity and even contradiction in their biomedical applications.
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Cell type: cell line | Technique: general | Disease/area: cancer, infectious disease | Head & neck (2025)
Head and neck squamous cell carcinoma (HNSCC) presents significant treatment challenges, particularly in cases unrelated to human papillomavirus (HPV). The chemokine receptor CXCR4, interacting with its ligand CXCL12, plays a crucial role in tumor proliferatio
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Cell type: cell line, tumor cell | Technique: general | Disease/area: cancer | Life science alliance (2025)
Glioblastoma is a major unmet clinical need characterized by striking inter- and intra-tumoral heterogeneity and a population of glioblastoma stem cells (GSCs), conferring aggressiveness and therapy resistance. GSCs communicate through a network of tumor-tumor
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Cell type: cancer cell, cell line | Technique: immunohistochemistry, western blot | Disease/area: cancer | Pancreas (2025)
This study assessed the anticancer potential of genetically modified exosomes engineered to express CD133-binding peptides on their surface and carry PD-L1 siRNA for the treatment of murine model of metastatic pancreatic cancer. CD133-targeting exosomes (tEx)
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Cell type: cancer cell, cell line, epithelial | Technique: general | Disease/area: cancer | Cancer research (2025)
Uterine serous carcinoma (USC) and uterine carcinosarcoma (UCS) tumors are uniquely aggressive, suggesting that the primary tumor is intrinsically equipped to disseminate and metastasize. Previous work identified mutational hotspots within PPP2R1A, which encod
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Cell type: T cell, cancer cell, cell line, tumor cell | Technique: general | Disease/area: cancer | Molecular cancer therapeutics (2025)
Identifying an optimal antigen for targeted cancer therapy is challenging as the antigen landscape on cancerous tissues mimics that of healthy tissues, with few unique tumor-specific antigens identified in individual patients. pH low insertion peptide (pHLIP)
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Cell type: cell line | Technique: general | Disease/area: cancer | Chinese medical journal (2025)
Oral squamous cell carcinoma (OSCC) is a prevalent type of cancer with a high mortality rate in its late stages. One of the major challenges in OSCC treatment is the resistance to epidermal growth factor receptor (EGFR) inhibitors. Therefore, it is imperative
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Cell type: cancer cell, cell line | Technique: general | Disease/area: cancer | Nutrients (2024)
(Abstract unavailable)
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Cell type: general | Technique: general | Disease/area: cancer, fibrosis, inflammation | Pharmaceuticals (Basel, Switzerland) (2024)
(Abstract unavailable)
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Cell type: general | Technique: CRISPR | Disease/area: cancer | Science advances (2024)
Single-nucleotide variants (SNVs) are extremely prevalent in human cancers, although most of these remain clinically unactionable. The programmable RNA nuclease CRISPR-Cas13 has been deployed to specifically target oncogenic RNAs. However, silencing oncogenic
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Cell type: cancer cell | Technique: general | Disease/area: cancer | Cancers (2024)
(Abstract unavailable)
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Cell type: general | Technique: EdU proliferation | Disease/area: cancer | Acta biochimica et biophysica Sinica (2024)
DNA replication stress is a significant contributor to spontaneous DNA damage and genome instability. While the impact of p53 deficiency on increasing DNA replication stress is known, the specific molecular mechanism underlying this phenomenon remains poorly u
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Cell type: cell line, tumor cell | Technique: EdU proliferation | Disease/area: cancer | Science signaling (2024)
Cancers invoke various pathways to mitigate external and internal stresses to continue their growth and progression. We previously reported that the eIF2 kinase GCN2 and the integrated stress response are constitutively active in prostate cancer (PCa) and are
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Cell type: cancer cell, cell line, tumor cell | Technique: EdU proliferation | Disease/area: cancer | International journal of molecular sciences (2024)
Peroxisome proliferator-activated receptors (PPARs), including PPAR-α, PPAR-β/δ, and PPAR-γ, are involved in various cellular responses, including metabolism and cell proliferation. Increasing evidence suggests that PPARs are closely associated with tumorigene
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Cell type: general | Technique: general | Disease/area: cancer | Molecular cell (2024)
Hyperproliferation driven by the protooncogene MYC may lead to tumor suppressor p53 activating DNA damage that has been presumed to derive from hypertranscription and over-replication. Here, we report that excessive MYC-topoisome (MYC/topoisomerase 1/topoisome
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Cell type: cell line | Technique: general | Disease/area: cancer, infectious disease | Viruses (2024)
The virions of plant viruses and their structurally modified particles (SP) represent valuable platforms for recombinant vaccine epitopes and antitumor agents. The possibility of modifying their surface with biological compounds makes them a tool for developin
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Cell type: endothelial | Technique: flow cytometry | Disease/area: arthritis, atherosclerosis, cancer, cardiovascular, inflammation | Biomolecules (2024)
Myeloperoxidase (MPO) plays a critical role in the innate immune response and has been suggested to be a surrogate marker of oxidative stress and inflammation, with elevated levels implicated in cardiovascular diseases, such as atherosclerosis and heart failur
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Cell type: cell line | Technique: general | Disease/area: cancer | Frontiers in oncology (2024)
The mutated in colorectal cancer (MCC) gene was initially identified as a candidate tumor suppressor gene in colorectal cancer, acting as a negative regulator of cell cycle progression. However, its functional roles in brain tumors, particularly glioblastoma,
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Cell type: cancer cell, cell line | Technique: general | Disease/area: cancer | Journal of nanobiotechnology (2024)
Metastasis and recurrence are the main challenges in cancer treatment. Among various therapeutic approaches, immunotherapy holds promise for preventing metastasis and recurrence. In this study, we evaluated the efficacy of treating primary cancer and blocking
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Cell type: cell line | Technique: knockout | Disease/area: cancer, inflammation | Molecular cell (2024)
Hepatocellular carcinoma (HCC) emerges from chronic inflammation, to which activation of hepatic stellate cells (HSCs) contributes by shaping a pro-tumorigenic microenvironment. Key to this process is p62, whose inactivation leads to enhanced hepatocarcinogene
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Cell type: cell line | Technique: general | Disease/area: cancer | BMB reports (2024)
The TP53 c.359A＞G mutation significantly disrupts the expression of the major TP53 transcript variant encoding p53 K120R by generating a new splice donor site. An antisense morpholino oligomer (AMO) targeting this mutation successfully restored normal splicing
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Cell type: HeLa | Technique: EdU proliferation | Disease/area: COVID-19, bone disease, cancer, infectious disease | Cell (2024)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution has resulted in viral escape from clinically authorized monoclonal antibodies (mAbs), creating a need for mAbs that are resilient to epitope diversification. Broadly neutralizing coronaviru
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Cell type: general | Technique: general | Disease/area: cancer | Nature communications (2024)
The primed epiblast acts as a transitional stage between the relatively homogeneous naïve epiblast and the gastrulating embryo. Its formation entails coordinated changes in regulatory circuits driven by transcription factors and epigenetic modifications. Using
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Cell type: epithelial, keratinocyte | Technique: knockout | Disease/area: cancer, inflammation, skin disease | Immunity (2024)
The surface of the skin is continually exposed to pro-inflammatory stimuli; however, it is unclear why it is not constantly inflamed due to this exposure. Here, we showed undifferentiated keratinocytes residing in the deep epidermis could trigger a strong infl
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Cell type: T cell, epithelial | Technique: immunohistochemistry | Disease/area: cancer | Journal of ovarian research (2024)
High grade serous ovarian cancer (HGSOC) is the most lethal gynecologic malignancy in which patients have still yet to respond meaningfully to clinically available immunotherapies. Hence, novel immune targets are urgently needed. Our past work has identified t
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Cell type: cancer cell, cell line | Technique: general | Disease/area: cancer | Cancer research (2024)
Pseudouridylation is a common RNA modification that is catalyzed by the family of pseudouridine synthases (PUS). Pseudouridylation can increase RNA stability and rigidity, thereby impacting RNA splicing, processing, and translation. Given that RNA metabolism i
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Cell type: general | Technique: knockout | Disease/area: cancer, infectious disease, inflammation | ImmunoHorizons (2024)
Neutrophil extracellular traps (NETs) function to control infectious agents as well as to propagate inflammatory response in a variety of disease conditions. DNA damage associated with chromatin decondensation and NACHT domain-leucine-rich repeat-and pyrin dom
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Cell type: HeLa, T cell, cell line | Technique: general | Disease/area: cancer, infectious disease | Nature communications (2024)
Targeted antineoplastic immunotherapies have achieved remarkable clinical outcomes. However, resistance to these therapies due to target absence or antigen shedding limits their efficacy and excludes tumours from candidacy. To address this limitation, here we
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Cell type: general | Technique: general | Disease/area: cancer | Frontiers in toxicology (2024)
Di(ethylhexyl) phthalate (DEHP) is a ubiquitous environmental contaminant to which humans are exposed via multiple routes. Human health risk assessments for this substance have recently been updated, focusing on reproductive toxicity, including DEHP, in the li
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Cell type: cell line, tumor cell | Technique: general | Disease/area: cancer | Cancer research communications (2024)
Renal cell carcinoma (RCC), the most common form of kidney cancer, is a heterogeneous disease with clear cell RCC (ccRCC) being the most prevalent and aggressive subtype. While most ccRCC tumors have elevated expression of angiopoietin-like4 (ANGPTL4), in our
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Cell type: general | Technique: knockout | Disease/area: cancer, fibrosis, inflammation, obesity | Biochimica et biophysica acta. Molecular and cell biology of lipids (2024)
Stearoyl-CoA desaturase-1 (SCD1) is a pivotal enzyme in lipogenesis, which catalyzes the synthesis of monounsaturated fatty acids (MUFA) from saturated fatty acids, whose ablation downregulates lipid synthesis, preventing steatosis and obesity. Yet deletion of
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Cell type: general | Technique: immunohistochemistry | Disease/area: cancer | Pituitary (2024)
Molecular mechanisms involved in the pathogenesis and tumor progression of pituitary adenomas (PA) remain incompletely understood. Corticotroph and somatotroph PA are associated with a high clinical burden, and despite improved surgical outcomes and medical tr
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Cell type: cancer cell | Technique: EdU proliferation, live-cell imaging | Disease/area: cancer | Cancers (2024)
Aberrant estrogen receptor (ERα) signaling mediates detrimental effects of tamoxifen including drug resistance and endometrial hyperplasia. ERα36, an alternative isoform of ERα, contributes to these effects. We have demonstrated that CK2 modulates ERα expressi
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Cell type: general | Technique: general | Disease/area: bone disease, cancer | iScience (2024)
Hematopoietic aging is associated with decreased hematopoietic stem cell (HSC) self-renewal capacity and myeloid skewing. We report that culture of bone marrow (BM) HSCs from aged mice with epidermal growth factor (EGF) suppressed myeloid skewing, increased mu
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