EVOS M5000 in Cancer & Oncology Research — Wave 3 Part 3
Peer-reviewed studies using the EVOS M5000 Imaging System for cancer cell imaging, proliferation, apoptosis, genome editing and tumour models. Each entry was discovered independently of Thermo Fisher's curated EVOS M5000 citations and verified to mention the EVOS M5000 Imaging System as a microscope in the full text. Paper cards link to Google Scholar, PubMed, PMC and DOI when available.
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Harnessing Decellularized Extracellular Matrix for Enhanced Fidelity in Colorectal Cancer Organoid and Cell-Derived Xenograft Models.
Cell type: cancer cell, cell line | Technique: general | Disease/area: cancer | Journal of microbiology and biotechnology (2024)
This study evaluates the efficacy of a decellularized intestine tissue-derived extracellular matrix (Intestine ECM) as a scaffold for culturing colorectal cancer (CRC) organoids and establishing cell-derived xenograft (CDX) models, comparing its performance to
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Cigarette Smoke Extract Induces MUC5AC Expression Through the ROS/ IP3R/Ca
Cell type: cell line, epithelial | Technique: immunofluorescence | Disease/area: cancer | International journal of chronic obstructive pulmonary disease (2024)
Chronic obstructive pulmonary disease (COPD) is caused by exposure to noxious external particles, air pollution, and the inhalation of cigarette smoke. Airway mucus hypersecretion particularly mucin5AC (MUC5AC), is a crucial pathological feature of COPD and is
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Hepatitis B Virus Covalently Closed Circular DNA Chromatin Immunoprecipitation Assay.
Cell type: general | Technique: qPCR | Disease/area: cancer, fibrosis, infectious disease | Methods in molecular biology (Clifton, N.J.) (2024)
Hepatitis B virus (HBV) is an obligate human hepatotropic DNA virus causing both transient and chronic infection. The livers of chronic hepatitis B patients have a high risk of developing liver fibrosis, cirrhosis, and hepatocellular carcinoma. The nuclear epi
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Combinatorial macrophage induced innate immunotherapy against Ewing sarcoma: Turning "Two Keys" simultaneously.
Cell type: cell line, macrophage, tumor cell | Technique: CRISPR, EdU proliferation, flow cytometry | Disease/area: cancer | Journal of experimental & clinical cancer research : CR (2024)
Macrophages play important roles in phagocytosing tumor cells. However, tumors escape macrophage phagocytosis in part through the expression of anti-phagocytic signals, most commonly CD47. In Ewing sarcoma (ES), we found that tumor cells utilize dual mechanism
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IDH1-mutant metabolite D-2-hydroxyglutarate inhibits proliferation and sensitizes glioma to temozolomide via down-regulating ITGB4/PI3K/AKT.
Cell type: T cell | Technique: general | Disease/area: cancer | Cell death discovery (2024)
The heterogeneous molecular subtypes of gliomas demonstrate varied responses to chemotherapy and distinct prognostic outcomes. Gliomas with Isocitrate dehydrogenase 1 (IDH1) mutation are associated with better outcomes and are more responsive to temozolomide (
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SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis.
Cell type: general | Technique: knockout | Disease/area: cancer | Nature communications (2024)
Mutations that decrease or increase the activity of the tyrosine phosphatase, SHP2 (encoded by PTPN11), promotes developmental disorders and several malignancies by varying phosphatase activity. We uncovered that SHP2 is a distinct class of an epigenetic enzym
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The Anti-Obesogenic Effects of Muscadine Grapes through Ciliary Neurotrophic Factor Receptor (Cntfr) and Histamine Receptor H1 (Hrh1) Genes in 3T3-L1 Differentiated Mouse Cells.
Cell type: adipocyte | Technique: EdU proliferation | Disease/area: cancer, cardiovascular, diabetes, obesity | Nutrients (2024)
Obesity and type 2 diabetes are prevalent metabolic diseases that have significant links to several chronic diseases, including cancer, diabetes, hypertension, and cardiovascular disease. Muscadine grape extracts have shown the potential to reduce adiposity an
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PD-L1 has a heterogeneous and dynamic expression in gastric cancer with implications for immunoPET.
Cell type: cancer cell, cell line | Technique: immunofluorescence | Disease/area: cancer | Frontiers in immunology (2024)
This study aimed to investigate the dynamics of programmed death-ligand 1 (PD-L1) expression, spatial heterogeneity, and binding affinity of FDA-approved anti-PD-L1 antibodies (avelumab and atezolizumab) in gastric cancer. Additionally, we determined how PD-L1
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The type of DNA damage response after decitabine treatment depends on the level of DNMT activity.
Cell type: cell line | Technique: general | Disease/area: cancer | Life science alliance (2024)
Decitabine and azacytidine are considered as epigenetic drugs that induce DNA methyltransferase (DNMT)-DNA crosslinks, resulting in DNA hypomethylation and damage. Although they are already applied against myeloid cancers, important aspects of their mode of ac
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FABP5-binding lipids regulate autophagy in differentiated SH-SY5Y cells.
Cell type: SH-SY5Y, cell line, neuron, tumor cell | Technique: general | Disease/area: Parkinson disease, cancer | PloS one (2024)
The motor features of Parkinson's disease result from loss of dopaminergic neurons in the substantia nigra with autophagy dysfunction being closely linked to this disease. While a large body of work focusing on protein effectors of autophagy has been repo
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Mitochondrial transfer from Adipose stem cells to breast cancer cells drives multi-drug resistance.
Cell type: cancer cell, cell line | Technique: EdU proliferation, confocal, immunofluorescence | Disease/area: cancer | Journal of experimental & clinical cancer research : CR (2024)
Breast cancer (BC) is a complex disease, showing heterogeneity in the genetic background, molecular subtype, and treatment algorithm. Historically, treatment strategies have been directed towards cancer cells, but these are not the unique components of the tum
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Targeting PD-L1 in cholangiocarcinoma using nanovesicle-based immunotherapy.
Cell type: cell line, epithelial, tumor cell | Technique: EdU proliferation | Disease/area: cancer | Molecular therapy : the journal of the American Society of Gene Therapy (2024)
This study demonstrates the potential of using biological nanoparticles to deliver RNA therapeutics targeting programmed death-ligand 1 (PD-L1) as a treatment strategy for cholangiocarcinoma (CCA). RNA therapeutics offer prospects for intracellular immune modu
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Combined treatment with cetuximab and STA9090 has synergistic anticancer effects on human non-small cell lung cancer.
Cell type: cell line | Technique: general | Disease/area: cancer | Acta biochimica et biophysica Sinica (2024)
Cetuximab (CET), a human murine chimeric IgG monoclonal antibody and an inhibitor of epidermal growth factor receptor (EGFR), has been shown to be effective in treating various types of cancer. However, its use is hindered by limitations such as resistance dev
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ACLY alternative splicing correlates with cancer phenotypes.
Cell type: T cell, epithelial | Technique: knockout | Disease/area: cancer | The Journal of biological chemistry (2024)
ATP-citrate lyase (ACLY) links carbohydrate and lipid metabolism and provides nucleocytosolic acetyl-CoA for protein acetylation. ACLY has two major splice isoforms: the full-length canonical "long" isoform and an uncharacterized "short" is
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Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation.
Cell type: cell line, epithelial | Technique: EdU proliferation | Disease/area: cancer | Developmental cell (2024)
The early mechanisms of spontaneous tumor initiation that precede malignancy are largely unknown. We show that reduced aPKC levels correlate with stem cell loss and the induction of revival and metaplastic programs in serrated- and conventional-initiated prema
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SGLT2 inhibitor promotes mitochondrial dysfunction and ER-phagy in colorectal cancer cells.
Cell type: cancer cell, cell line | Technique: western blot | Disease/area: cancer, diabetes | Cellular & molecular biology letters (2024)
Sodium-glucose transporter 2 (SGLT2) inhibitors (iSGLT2) are approved medications for type 2 diabetes. Recent studies indicate that iSGLT2 inhibit the growth of some cancer cells. However, the mechanism(s) remains to be fully elucidated. The SGLT2 levels were
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The Proteasome Inhibitor CEP-18770 Induces Cell Death in Medulloblastoma.
Cell type: cell line | Technique: EdU proliferation | Disease/area: cancer | Pharmaceutics (2024)
Medulloblastomas (MBs) represent the most prevalent malignant solid tumors in kids. The conventional treatment regimen for MBs includes surgical removal of the tumor, followed by radiation and chemotherapy. However, this approach is associated with significant
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Induced Pluripotent Stem Cell-Derived Fibroblasts Efficiently Engage Senescence Pathways but Show Increased Sensitivity to Stress Inducers.
Cell type: fibroblast, iPSC | Technique: general | Disease/area: cancer, infectious disease, skin disease | Cells (2024)
The risk of aberrant growth of induced pluripotent stem cell (iPSC)-derived cells in response to DNA damage is a potential concern as the tumor suppressor genes TP53 and CDKN2A are transiently inactivated during reprogramming. Herein, we evaluate the integrity
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Synergistic Action of Benzyl Isothiocyanate and Sorafenib in a Nanoparticle Delivery System for Enhanced Triple-Negative Breast Cancer Treatment.
Cell type: MDA-MB-231, T cell | Technique: general | Disease/area: cancer | Cancers (2024)
Triple-negative breast cancer (TNBC) presents a therapeutic challenge due to its complex pathology and limited treatment options. Addressing this challenge, our study focuses on the effectiveness of combination therapy, which has recently become a critical str
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Amino Terminal Acetylation of HOXB13 Regulates the DNA Damage Response in Prostate Cancer.
Cell type: general | Technique: general | Disease/area: cancer | Cancers (2024)
Advanced localized prostate cancers (PC) recur despite chemotherapy, radiotherapy and/or androgen deprivation therapy. We recently reported HOXB13 lysine (K)13 acetylation as a gain-of-function modification that regulates interaction with the SWI/SNF chromatin
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The heterogeneous sensitivity of pediatric brain tumors to different oncolytic viruses is predicted by unique gene expression profiles.
Cell type: general | Technique: GFP | Disease/area: cancer, infectious disease | Molecular therapy. Oncology (2024)
Despite decades of research, the prognosis of high-grade pediatric brain tumors (PBTs) remains dismal; however, recent cases of favorable clinical responses were documented in clinical trials using oncolytic viruses (OVs). In the current study, we employed fou
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Quetiapine Significantly Improves the Effectiveness of Radiotherapy in Combating Hepatocellular Carcinoma Progression in a Hep3B Xenograft Mouse Model.
Cell type: cell line | Technique: general | Disease/area: cancer | In vivo (Athens, Greece) (2024)
In hepatocellular carcinoma (HCC) treatment, radiotherapy (RT) stands as a pivotal approach, yet the emergence of radioresistance poses a formidable challenge. This study aimed to explore the potential synergy between quetiapine and RT for HCC treatment. A Hep
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Interleukin 33 supports squamous cell carcinoma growth via a dual effect on tumour proliferation, migration and invasion, and T cell activation.
Cell type: T cell, cancer cell, cell line, epithelial | Technique: general | Disease/area: cancer, skin disease | Cancer immunology, immunotherapy : CII (2024)
Interleukin (IL)-33 is an important cytokine in the tumour microenvironment; it is known to promote the growth and metastasis of solid cancers, such as gastric, colorectal, ovarian and breast cancer. Our group demonstrated that the IL-33/ST2 pathway enhances t
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Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program.
Cell type: general | Technique: EdU proliferation | Disease/area: cancer | NPJ breast cancer (2024)
Research on metastatic cancer has been hampered by limited sample availability. Here we present the breast cancer post-mortem tissue donation program UPTIDER and show how it enabled sampling of a median of 31 (range: 5-90) metastases and 5-8 liquids per patien
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ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs.
Cell type: cell line, tumor cell | Technique: general | Disease/area: cancer | Cancer research (2024)
Alveolar soft part sarcoma (ASPS) is a rare mesenchymal malignancy driven by the ASPSCR1::TFE3 fusion. A better understanding of the mechanisms by which this oncogenic transcriptional regulator drives cancer growth is needed to help identify potential therapeu
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Long-term imaging and spatio-temporal control of living cells using targeted light based on closed-loop feedback.
Cell type: general | Technique: EdU proliferation, live-cell imaging, wound healing | Disease/area: cancer, wound healing | Journal of micro-bio robotics (2024)
The ability to optically interact with cells on both an individual and collective level has applications from wound healing to cancer treatment. Building systems that can facilitate both localised light illumination and visualisation of cells can, however, be
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Selective Targeting of Regulated Rhabdomyosarcoma Cells by Trinuclear Ruthenium(II)-Arene Complexes.
Cell type: T cell, cancer cell, cell line | Technique: general | Disease/area: cancer | Journal of medicinal chemistry (2024)
The use of benzimidazole-based trinuclear ruthenium(II)-arene complexes (
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FZD7-Targeted Nanoparticles to Enhance Doxorubicin Treatment of Triple-Negative Breast Cancer.
Cell type: general | Technique: general | Disease/area: cancer | ACS omega (2024)
Doxorubicin (DOX) is a chemotherapy agent commonly used to treat triple-negative breast cancer (TNBC), but it has insufficient efficacy against the disease and considerable toxicity due to its off-target delivery. To improve the specificity of DOX for TNBC, we
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Cutting-Edge HEK293T Protein-Integrated Lipid Nanostructures: Boosting Biocompatibility and Efficacy.
Cell type: HEK293, HeLa, T cell, cancer cell, cell line | Technique: general | Disease/area: cancer | International journal of molecular sciences (2024)
Recently, artificial exosomes have been developed to overcome the challenges of natural exosomes, such as production scalability and stability. In the production of artificial exosomes, the incorporation of membrane proteins into lipid nanostructures is emergi
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Engineered therapeutic antibodies with mannose 6-phosphate analogues as a tool to degrade extracellular proteins.
Cell type: endothelial | Technique: general | Disease/area: cancer, inflammation | Frontiers in immunology (2024)
Inducing the degradation of pathological soluble antigens could be the key to greatly enhancing the efficacy of therapeutic monoclonal antibodies (mAbs), extensively used in the treatment of autoimmune and inflammatory disorders or cancer. Lysosomal targeting
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PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures.
Cell type: general | Technique: general | Disease/area: cancer | Neoplasia (New York, N.Y.) (2024)
Gene fusions are common in high-grade serous ovarian cancer (HGSC). Such genetic lesions may promote tumorigenesis, but the pathogenic mechanisms are currently poorly understood. Here, we investigated the role of a PIK3R1-CCDC178 fusion identified from a patie
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Cold-Responsive Hyaluronated Upconversion Nanoplatform for Transdermal Cryo-Photodynamic Cancer Therapy.
Cell type: general | Technique: general | Disease/area: cancer, skin disease | Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2024)
Cryotherapy leverages controlled freezing temperature interventions to engender a cascade of tumor-suppressing effects. However, its bottleneck lies in the standalone ineffectiveness. A promising strategy is using nanoparticle therapeutics to augment the effic
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H
Cell type: cell line | Technique: general | Disease/area: cancer | Cells (2024)
Hydrogen sulfide (H
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A retrotransposon-derived DNA zip code internalizes myeloma cells through Clathrin-Rab5a-mediated endocytosis.
Cell type: cancer cell, cell line | Technique: EdU proliferation, confocal, flow cytometry | Disease/area: cancer | Frontiers in oncology (2024)
We have demonstrated that transposons derived from ctDNA can be transferred between cancer cells. The present research aimed to investigate the cellular uptake and intracellular trafficking of Multiple Myeloma-zip code (MM-ZC), a cell-specific zip code, in mye
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IGF2BP3 enhances lipid metabolism in cervical cancer by upregulating the expression of SCD.
Cell type: cell line, tumor cell | Technique: CCK-8, flow cytometry | Disease/area: cancer, wound healing | Cell death & disease (2024)
Cervical cancer (CC) is the most common gynecologic malignancy, which seriously threatens the health of women. Lipid metabolism is necessary for tumor proliferation and metastasis. However, the molecular mechanism of the relationship between CC and lipid metab
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Periodic changes of cyclin D1 mRNA stability are regulated by PC4 modifications in the cell cycle.
Cell type: cell line | Technique: general | Disease/area: cancer | The Journal of cell biology (2024)
The cell cycle is a highly regulated process in which proteins involved in cell cycle progression exhibit periodic expression patterns, controlled by specific mechanisms such as transcription, translation, and degradation. However, the precise mechanisms under
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The Oncolytic Activity of Zika Viral Therapy in Human Neuroblastoma In Vivo Models Confers a Major Survival Advantage in a CD24-dependent Manner.
Cell type: general | Technique: general | Disease/area: cancer, infectious disease | Cancer research communications (2024)
Neuroblastoma is the most common extracranial tumor, accounting for 15% of all childhood cancer-related deaths. The long-term survival of patients with high-risk tumors is less than 40%, and MYCN amplification is one of the most common indicators of poor outco
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HBV infection effects prognosis and activates the immune response in intrahepatic cholangiocarcinoma.
Cell type: T cell | Technique: immunohistochemistry | Disease/area: cancer, infectious disease | Hepatology communications (2024)
The impact of HBV infection on the prognosis of patients with intrahepatic cholangiocarcinoma (ICC) remains uncertain, and the underlying mechanism has not been elucidated. This study aims to explore the potential mechanism via clinical perspectives and immune
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The homologous tumor-derived-exosomes loaded with miR-1270 selectively enhanced the suppression effect for colorectal cancer cells.
Cell type: HepG2, MSC, T cell, cancer cell, cell line, tumor cell | Technique: EdU proliferation, flow cytometry | Disease/area: cancer, wound healing | Cancer medicine (2024)
Colorectal cancer (CRC), known as prevalent cancer, has risen to be the leading cause of cancer-related death. Engineered exosomes had attracted much attention since they acted as carriers to deliver small molecule drugs, therapeutic nucleic acids, and polypep
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Engrailed-1 Promotes Pancreatic Cancer Metastasis.
Cell type: neuron | Technique: general | Disease/area: cancer | Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2024)
Engrailed-1 (EN1) is a critical homeodomain transcription factor (TF) required for neuronal survival, and EN1 expression has been shown to promote aggressive forms of triple negative breast cancer. Here, it is reported that EN1 is aberrantly expressed in a sub
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Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis.
Cell type: HEK293, T cell, cancer cell, cell line, tumor cell | Technique: EdU proliferation | Disease/area: cancer | Molecular cancer therapeutics (2024)
The histone lysine demethylases KDM4A-C are involved in physiologic processes including stem cell identity and self-renewal during development, DNA damage repair, and cell-cycle progression. KDM4A-C are overexpressed and associated with malignant cell behavior
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Spatial Transcriptomics Suggests That Alterations Occur in the Preneoplastic Breast Microenvironment of BRCA1/2 Mutation Carriers.
Cell type: epithelial | Technique: general | Disease/area: cancer | Molecular cancer research : MCR (2024)
Breast cancer is the most common cancer in females, affecting one in every eight women and accounting for the majority of cancer-related deaths in women worldwide. Germline mutations in the BRCA1 and BRCA2 genes are significant risk factors for specific subtyp
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Assessment of an Anticancer Effect of the Simultaneous Administration of MM-129 and Indoximod in the Colorectal Cancer Model.
Cell type: cancer cell, cell line | Technique: general | Disease/area: cancer | Cancers (2023)
(1) Background: The purpose of the given study was to examine the antitumor activity of the simultaneous administration of MM-129, a 1,2,4-triazine derivative, and indoximod (IND), the kynurenine pathway inhibitor, toward colon cancer. (2) Methods: The efficie
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Smart and low-cost fluorometer for identifying breast cancer malignancy based on lipid droplets accumulation.
Cell type: MCF-7, MDA-MB-231, cancer cell, cell line | Technique: fluorescence | Disease/area: cancer | PloS one (2023)
The most common cause of breast cancer-related death is tumor recurrence. To develop more effective treatments, the identification of cancer cell specific malignancy indicators is therefore critical. Lipid droplets are known as an emerging hallmark in aggressi
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Optimization of a Three-Dimensional Culturing Method for Assessing the Impact of Cisplatin on Notch Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC).
Cell type: cell line, fibroblast, tumor cell | Technique: EdU proliferation | Disease/area: cancer | Cancers (2023)
Head and neck squamous cell carcinoma (HNSCC) is a prevalent cancer type, with cisplatin being a primary treatment approach. However, drug resistance and therapy failure pose a significant challenge, affecting nearly 50% of patients over time. This research ha
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Integration of xeno-free single-cell cloning in CRISPR-mediated DNA editing of human iPSCs improves homogeneity and methodological efficiency of cellular disease modeling.
Cell type: cell line, iPSC | Technique: CRISPR, transfection | Disease/area: cancer | Stem cell reports (2023)
The capability to generate induced pluripotent stem cell (iPSC) lines, in tandem with CRISPR-Cas9 DNA editing, offers great promise to understand the underlying genetic mechanisms of human disease. The low efficiency of available methods for homogeneous expans
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Bioinspired Collagen/Hyaluronic Acid/Fibrin-Based Hydrogels for Soft Tissue Engineering: Design, Synthesis, and In Vitro Characterization.
Cell type: fibroblast | Technique: general | Disease/area: cancer, skin disease | Journal of functional biomaterials (2023)
A major challenge for future drug development comprises finding alternative models for drug screening. The use of animal models in research is highly controversial, with an ongoing debate on their ethical acceptability. Also, animal models are often poorly pre
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Engineering Cell-Derived Nanovesicles for Targeted Immunomodulation.
Cell type: MSC, T cell, tumor cell | Technique: general | Disease/area: cancer | Nanomaterials (Basel, Switzerland) (2023)
Extracellular vesicles (EVs) show promise for targeted drug delivery but face production challenges with low yields. Cell-derived nanovesicles (CDNVs) made by reconstituting cell membranes could serve as EV substitutes. In this study, CDNVs were generated from
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Modulation of Influenza A virus NS1 expression reveals prioritization of host response antagonism at single-cell resolution.
Cell type: epithelial | Technique: general | Disease/area: cancer, infectious disease, inflammation | Frontiers in microbiology (2023)
Influenza A virus (IAV) is an important human respiratory pathogen that causes significant seasonal epidemics and potential devastating pandemics. As part of its life cycle, IAV encodes the multifunctional protein NS1, that, among many roles, prevents immune d
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Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery and treatment of cancer.
Cell type: general | Technique: general | Disease/area: cancer | Cancer nanotechnology (2023)
Combining the power of magnetic guidance and the biological activities of stem cells transformed into biohybrid microrobots holds great promise for the treatment of several diseases including cancer. We found that human MSCs can be readily loaded with magnetic
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A humanized orthotopic mouse model for preclinical evaluation of immunotherapy in Ewing sarcoma.
Cell type: general | Technique: general | Disease/area: bone disease, cancer | Frontiers in immunology (2023)
The advent of novel cancer immunotherapy approaches is revolutionizing the treatment for cancer. Current small animal models for most cancers are syngeneic or genetically engineered mouse models or xenograft models based on immunodeficient mouse strains. These
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Phenethyl isothiocyanate and dasatinib combination synergistically reduces hepatocellular carcinoma growth via cell cycle arrest and oxeiptosis.
Cell type: general | Technique: EdU proliferation | Disease/area: cancer | Frontiers in pharmacology (2023)
(Abstract unavailable)
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A Robust and Standardized Approach to Quantify Wound Closure Using the Scratch Assay.
Cell type: fibroblast, keratinocyte | Technique: wound healing | Disease/area: cancer, wound healing | Methods and protocols (2023)
The scratch assay is an in vitro assay that allows for high-throughput quantification of wound closure by keratinocytes and fibroblasts with relative ease. However, this assay is amenable to experimental variables, which can result in false-positive and false-
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β
Cell type: T cell, cell line | Technique: EdU proliferation | Disease/area: cancer | Cell death & disease (2023)
The β2-Adrenergic receptor (β2-ARs) is a cell membrane-spanning G protein-coupled receptors (GPCRs) physiologically involved in stress-related response. In many cancers, the β2-ARs signaling drives the tumor development and transformation, also promoting the r
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MiR-148a-3p Promotes Colorectal Cancer Cell Ferroptosis by Targeting SLC7A11.
Cell type: cancer cell, epithelial, tumor cell | Technique: EdU proliferation | Disease/area: cancer | Cancers (2023)
Ferroptosis, an iron-dependent form of cell death, and dysregulated microRNA (miRNA) expression correlate with colorectal cancer (CRC) development and progression. The tumor suppressor ability of miR-148a-3p has been reported for several cancers. Nevertheless,
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