EVOS M5000 in Cancer & Oncology Research — Wave 3

Impact of Neuroendocrine Neoplasm-Specific Systemic Treatments on Somatostatin Receptors Expression and Function in Neuroendocrine Tumor Cells.

Cell type: tumor cell | Technique: general | Disease/area: cancer | Cancers (2026)

(Abstract unavailable)

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Cytokines IL-6, IL-10, and CCL5 Secreted by Infiltrating B Cells Promote Cell Migration of Human Prostate Cancer Cell Lines.

Cell type: cancer cell, cell line, epithelial | Technique: immunocytochemistry, western blot | Disease/area: cancer | Oncology research (2026)

The progression of prostate cancer cells to metastasis is supported by their tumor microenvironment. Within this microenvironment, infiltrating immune cells, such as B cells, can be either anti-tumorigenic or pro-tumorigenic. Our preliminary data showed that a

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Identification of two

Cell type: cell line | Technique: general | Disease/area: cancer, infectious disease | mBio (2026)

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Inhibition of ZBTB7B-mediated ADPGK transcription by NEDD4 impedes glycolysis and progression of lung adenocarcinoma.

Cell type: cell line | Technique: general | Disease/area: cancer | Oncogenesis (2026)

Lung adenocarcinoma, the predominant type of non-small cell lung cancer, is associated with poor survival outcomes due to late-stage diagnosis, resistance to therapy, and lack of effective metabolic-targeted strategies. Increased glycolysis is a hallmark of LU

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Connective tissue growth factor contributes to resistance to anti-angiogenic therapies in renal cancer.

Cell type: T cell, cell line, tumor cell | Technique: general | Disease/area: cancer, fibrosis | Theranostics (2026)

Clear cell renal cell carcinoma (ccRCC) is predominantly treated with anti-angiogenic therapies (AATs), such as sunitinib and axitinib. While these therapies initially improve outcomes, resistance frequently emerges, limiting long-term efficacy. Understanding

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comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders.

Cell type: iPSC, macrophage | Technique: EdU proliferation | Disease/area: bone disease, cancer, cardiovascular, inflammation | Cell stem cell (2026)

The bone marrow is the primary site of blood and immune cell production in postnatal life. Current human models do not capture lympho-myeloid hematopoiesis and the stromal diversity needed for lifelong blood and immune maintenance. Here, we introduce comBO (co

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Mechanism of IL-4 mediated RPL19 promoting malignant progression in HER2 positive breast cancer.

Cell type: cancer cell, cell line, macrophage, tumor cell | Technique: EdU proliferation | Disease/area: cancer | Breast cancer research : BCR (2026)

BACKGROUND: Despite recent improvements in prognosis, breast cancer remains the leading cause of cancer-related mortality in women worldwide. Survival rates vary across breast cancer subtypes. HER2, an oncogene, is amplified in approximately 25% of primary bre

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Genetic ablation of interleukin-17A augments fibrosis in a mouse model of cholestatic liver injury.

Cell type: T cell, cell line, fibroblast | Technique: flow cytometry, knockout | Disease/area: cancer, fibrosis, inflammation | PloS one (2026)

The underlying mechanisms contributing to cholestatic liver injury remain unclear. The pro-inflammatory leukocyte-restricted cytokine interleukin-17A (IL-17A) has been implicated in human cholestatic liver injury. However, mechanistic insights are lacking and

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Impact of neuroendocrine neoplasm-specific systemic treatments on expression and function of CXCR4 in neuroendocrine tumor cells.

Cell type: cell line, tumor cell | Technique: EdU proliferation, immunohistochemistry, western blot | Disease/area: cancer | Scientific reports (2026)

As neuroendocrine neoplasms (NEN) undergo increasing dedifferentiation, CXC chemokine receptor type 4 (CXCR4) becomes upregulated. Higher levels of CXCR4 are associated with invasive growth, metastasis formation, and poor prognosis. CXCR4 is considered a poten

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Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma.

Cell type: T cell, epithelial | Technique: general | Disease/area: cancer | Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2026)

Therapy-resistant neuroblastoma (NB) reflects a lethal convergence of cellular plasticity and immune escape, yet the molecular drivers remain elusive. Here, we identify retinal degeneration protein 3 (RD3) as a master regulator of NB lineage fidelity and tumor

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Critical role for a high-plasticity cell state in lung cancer.

Cell type: cancer cell, cell line | Technique: general | Disease/area: cancer | Nature (2026)

Plasticity-the ability of cells to undergo phenotypic transitions-drives cancer progression and therapy resistance

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Inhibition of FOS-Like Antigen 1 Reduces Chemoresistance to Temozolomide Through Stemness Reprogramming via IL-6/STAT3

Cell type: general | Technique: EdU proliferation | Disease/area: cancer | MedComm (2026)

Glioblastoma (GBM) is the most lethal brain tumor, characterized by strong resistance to conventional therapies. Despite recent therapeutic advancements, overcoming chemoresistance remains a major challenge. Here, we identified FOS-like antigen 1 (FOSL1) as a

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Glycolytic heterogeneity drives metabolic-targeted therapy in pancreatic ductal adenocarcinoma.

Cell type: general | Technique: EdU proliferation | Disease/area: cancer | Signal transduction and targeted therapy (2026)

Pancreatic ductal adenocarcinoma is traditionally characterized as a glycolytic tumor. However, the extent and clinical relevance of its metabolic heterogeneity remain poorly understood. In this study, we investigated whether glycolytic activity follows a cons

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Hepatocellular carcinoma-linked

Cell type: general | Technique: general | Disease/area: cancer | iScience (2026)

AXIN1 organizes assembly of a destruction complex that degrades the transcriptional co-activator β-catenin, thereby preventing inappropriate Wnt/β-catenin signaling. In hepatocellular carcinoma (HCC),

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Human organoid tumor transplantation identifies functional glioblastoma-microenvironment communication mediated by PTPRZ1.

Cell type: cancer cell, cell line, epithelial, tumor cell | Technique: flow cytometry | Disease/area: cancer | Cell reports (2026)

Glioblastoma is the most aggressive and deadly form of brain cancer. Here, we leverage our human organoid tumor transplantation (HOTT) co-culture system to explore how extrinsic cues modulate glioblastoma cell types and behavior. HOTT recapitulates core featur

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Binimetinib and encorafenib for the treatment of advanced solid tumors with non-V600E BRAF mutations: results from the Phase II BEAVER trial.

Cell type: T cell, cell line | Technique: general | Disease/area: cancer | Nature communications (2026)

Class 2 and 3 non-V600E BRAF mutations are oncogenic drivers in many cancer types. Currently, there are no established targeted therapies with proven efficacy for cancers with non-V600E BRAF mutations. We developed the investigator-initiated, Phase II BEAVER c

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Lenvatinib Suppresses Colorectal Cancer Cell Growth, Migration, and Invasion

Cell type: cancer cell, cell line | Technique: EdU proliferation, MTT, flow cytometry, western blot | Disease/area: cancer | In vivo (Athens, Greece) (2026)

Colorectal cancer (CRC) remains a major cause of cancer mortality. Lenvatinib, a multi-kinase inhibitor, has emerging anticancer potential, but its effects in CRC are not fully defined. The aim of this study was to identify potential treatment mechanism and ef

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Corneal Nerve Regeneration via MSC-Derived EVs: Tissue Source and Culture Dimensionality Dictate miRNA Cargo and Therapeutic Efficacy.

Cell type: MSC, epithelial, neuron | Technique: western blot | Disease/area: bone disease, cancer | Small (Weinheim an der Bergstrasse, Germany) (2026)

Extracellular vesicles (EVs) are emerging as critical mediators of intercellular communication and tissue repair, offering a promising cell-free platform for regenerative therapies. In the cornea, sensory nerves are critical for maintaining epithelial integrit

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A KRAS

Cell type: T cell | Technique: general | Disease/area: cancer | Molecular therapy. Oncology (2025)

Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations have been detected at high rates in various tumor types, making them one of the most commonly mutated oncogenes. Limited relevant binding pockets have rendered these mutants undruggable for many decad

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Potent surface antimicrobial activity of hydrolyzable tannins from Aleppo oak galls.

Cell type: general | Technique: EdU proliferation | Disease/area: cancer, infectious disease, skin disease | Scientific reports (2025)

Surface antimicrobial agents provide a first line of defense against pathogens, especially for immunocompromised individuals. Insect-induced plant galls, tumor-like structures formed on plant surfaces by insect larvae, have long been used as sources of antimic

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IKAROS regulates human T cell phenotype at a thymic and postthymic level.

Cell type: T cell | Technique: EdU proliferation | Disease/area: cancer | JCI insight (2025)

The transcription factor IKAROS, encoded by IKZF1, is crucial for lymphocyte development and differentiation. Germline heterozygous IKZF1 mutations cause B cell immunodeficiency, but also affect T cells. Patients with IKZF1 haploinsufficiency (HI) or dimerizat

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CRISPR editing of HPFH3 genotype induces γ-globin expression and reverses sickle cell disease and β-thalassemia phenotypes.

Cell type: T cell, cell line | Technique: CRISPR, EdU proliferation | Disease/area: cancer | Stem cell research & therapy (2025)

Hereditary persistence of Fetal Hemoglobin (HPFH) is a benign condition known to mitigate symptoms in individuals with co-inherited β-hemoglobinopathies, such as β-thalassemia (BT) and sickle cell disease (SCD), through the reactivation of fetal hemoglobin (Hb

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Sulphonamide derivatives with a triazine core as novel inducers of apoptosis and pyroptosis in glioblastoma multiforme cells.

Cell type: cell line, tumor cell | Technique: general | Disease/area: cancer | Journal of enzyme inhibition and medicinal chemistry (2025)

Glioblastoma multiforme (GBM) is a highly aggressive brain tumour with few effective treatment options. This study evaluated two novel triazine-based sulphonamides, MM118 and MM119, for their anticancer effects on GBM cells.

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Targeting cystatin F activation enhances NK cell cytotoxicity in glioblastoma models.

Cell type: cell line, microglia | Technique: EdU proliferation | Disease/area: cancer | Frontiers in immunology (2025)

Glioblastoma (GBM) is a highly invasive brain tumor with limited treatment options and poor prognosis. Natural killer (NK) cells are key effectors of antitumor immunity, capable of eliminating cancer stem-like cells. However, GBM creates an immunosuppressive m

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Natural Compound Melatonin Suppresses Breast Cancer Development by Regulating Circadian Rhythm.

Cell type: cell line | Technique: general | Disease/area: cancer | Nutrients (2025)

(Abstract unavailable)

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Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.

Cell type: T cell, cell line | Technique: EdU proliferation, flow cytometry, knockout | Disease/area: cancer | Frontiers in immunology (2025)

Hepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. Despite significant progress in systemic and immune-based therapies, many patients develop resistance or fail to resp

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Inhibition of the RAC/PAK Signaling Axis Enhances the Potency of MAPK Cascade Inhibitors Against Uveal Melanoma.

Cell type: cell line, melanocyte | Technique: general | Disease/area: cancer | Biomolecules (2025)

Uveal melanoma is a melanocyte-derived malignancy of the eye with a high propensity for liver metastasis. Metastatic uveal melanoma is associated with high mortality and is poorly responsive to currently available therapies. Most uveal melanoma cases are drive

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Efficient identification of new small molecules targeting succinate dehydrogenase in non-small cell lung cancer.

Cell type: cancer cell, cell line | Technique: EdU proliferation | Disease/area: cancer, cardiovascular | Cancer cell international (2025)

Lung cancer treatment efficacy remains a challenge due to limited therapeutic targets. Succinate dehydrogenase (SDH) enzyme, a crucial enzyme linking the citric acid cycle and the electron transport chain, is implicated in cancer metabolism. While existing com

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Ebselen Suppresses Breast Cancer Tumorigenesis by Inhibiting YTHDF1-Mediated c-Fos Expression.

Cell type: cell line | Technique: general | Disease/area: cancer | International journal of molecular sciences (2025)

YTHDF1, an N6-methyladenosine (m

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Nanoparticle-boosted myeloid-derived suppressor cell therapy for immune reprogramming in multiple sclerosis.

Cell type: T cell | Technique: EdU proliferation | Disease/area: cancer, inflammation | Science advances (2025)

Massive immune cell infiltration and persistent inflammation in the central nervous system (CNS) are key hallmarks of multiple sclerosis. Here, we report a myeloid-derived suppressor cell (MDSC)-based therapeutic strategy, named CNS Immune Targeting Enabled by

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FASN promotes the stemness of cancer stem cells and protects colorectal cancer cells from ferroptosis by inhibiting the activation of SREBP2.

Cell type: cancer cell, cell line | Technique: EdU proliferation, flow cytometry, western blot | Disease/area: cancer | Frontiers in immunology (2025)

Fatty acid synthase (FASN) is a key regulator of lipid metabolism, but its role in colorectal cancer (CRC) stemness and ferroptosis remains unclear. FASN expression in CRC was analyzed using TCGA data and validated in CRC cell lines (CACO-2, HCT116, SW480) and

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ATE1 promotes breast cancer progression via arginylation-dependent regulation of MAPK-MYC signaling.

Cell type: MDA-MB-231, cancer cell, cell line, epithelial | Technique: flow cytometry | Disease/area: cancer | Cell communication and signaling : CCS (2025)

Arginyl-tRNA-protein transferase (ATE1) catalyzes N-terminal arginylation, a regulatory protein modification implicated in various cellular processes, including proliferation, apoptosis, and migration. Although ATE1 has context-dependent roles in cancer, its s

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Targeting a pathogenic cryptic exon that drives HLRCC to induce exon skipping.

Cell type: general | Technique: general | Disease/area: cancer | Molecular therapy. Nucleic acids (2025)

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is an autosomal dominant cancer predisposition syndrome driven by the loss of fumarate hydratase (FH) activity. Recently, we identified a pathogenic variant in intron 9 of the

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An endogenous cluster of target-directed microRNA degradation sites induces decay of distinct microRNA families.

Cell type: general | Technique: general | Disease/area: cancer | Cell reports (2025)

While much is known about microRNA (miRNA) biogenesis and targeting, relatively less is understood about miRNA decay. Target-directed miRNA degradation (TDMD) is a mechanism in metazoans where certain RNAs can "trigger" miRNA decay. All known TDMD tr

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Magnolol as a Radiotherapy Enhancer in Oral Squamous Cell Carcinoma: Targeting the EGFR/NF-κB Pathway and Immune Modulation.

Cell type: T cell, cell line, macrophage | Technique: EdU proliferation | Disease/area: cancer, inflammation | Journal of cellular and molecular medicine (2025)

Oral cancer, particularly oral squamous cell carcinoma (OSCC), often exhibits resistance to standard treatments like surgery, chemotherapy, and radiation therapy (RT). Magnolol, a bioactive compound from the bark of Magnolia officinalis, is recognised for its

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Cerium oxide nanoparticles prepared through Bio-combustion using Ficus carica as effective antioxidant, anticancer and dye degrading agent.

Cell type: general | Technique: EdU proliferation | Disease/area: cancer | Scientific reports (2025)

The rising levels of environmental contamination and oxidative stress disorders have led to a growing demand for multifunctional nanomaterials that possess both biomedical and catalytic importance. CeO

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Co-Targeting BCL-xL with MCL-1 Induces Lethal Mitochondrial Dysfunction in Diffuse Mesothelioma.

Cell type: cell line | Technique: EdU proliferation | Disease/area: cancer, cardiovascular | Molecular cancer therapeutics (2025)

Diffuse mesothelioma is a rare but highly aggressive and treatment-resistant neoplasm with low survival rates. Effective therapeutic strategies are limited, and resistance to treatment is a major obstacle. Myeloid cell leukemia (MCL)-1 and B-cell leukemia (BCL

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Kap1 Regulates Protein Stability of Nanog by Interfering with Fbxw8-Dependent Ubiquitination.

Cell type: cancer cell | Technique: general | Disease/area: cancer | International journal of stem cells (2025)

Nanog is a key transcription factor that regulates the self-renewal and pluripotency of embryonic stem cells (ESCs). Although Kap1 has been demonstrated to regulate the stability of stemness factors, including Oct4 and Lin28A, its role in regulating Nanog prot

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PCP4 inhibits the progression of prostate cancer through Ca

Cell type: cell line | Technique: EdU proliferation | Disease/area: cancer | Frontiers in immunology (2025)

The development of prostate cancer (PCa) remains a major health threat for men worldwide. Calcium/Calmodulin signaling pathway has been implicated to the initiation and progression of diverse human cancers. Loss or downregulation of Purkinje cell protein 4 (PC

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Cold Atmospheric Plasma Selectively Disrupts Breast Cancer Growth in a Bioprinted 3D Tumor-Stroma Co-Culture Model.

Cell type: MDA-MB-231, MSC, cancer cell, cell line, tumor cell | Technique: general | Disease/area: bone disease, cancer | Advanced healthcare materials (2025)

Spine metastases are the most common bone site for breast cancer, with evolving surgery and multidisciplinary care improving outcomes. Current treatments, including chemotherapy and invasive surgery, may damage healthy tissue and leave residual tumors that lea

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The T-Box Transcription Factors TBX2 and TBX3 Are Molecular Targets of Piroctone Olamine in the Treatment of Pancreatic Cancer.

Cell type: cell line, tumor cell | Technique: EdU proliferation | Disease/area: cancer | Journal of cellular and molecular medicine (2025)

Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate of < 10% and its incidences are continuously rising worldwide. This highlights an urgent need for effective therapies to reduce its burden. Repurposing commercially available non-cancer

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Simvastatin suppresses spinal cord metastasis of medulloblastoma at clinically significant doses.

Cell type: cell line | Technique: EdU proliferation | Disease/area: cancer | Cell death & disease (2025)

Medulloblastomas (MBs) are aggressive brain cancers and represent the most common primary malignant tumour in children. Current treatment protocols involve an intensive regimen of surgery, radiation therapy and chemotherapy, guided by histopathology and risk s

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Submicron-sized superantigen biomimetic liposomes with highly efficient pulmonary accumulation to remodel local immune microenvironment for cancer chemoimmunotherapy.

Cell type: general | Technique: general | Disease/area: cancer, infectious disease | Acta pharmaceutica Sinica. B (2025)

Metastatic lung cancer continues to cause a high number of deaths due to high malignancy and poor prognosis, and the efficacy of typical chemotherapy or immunotherapy is less than ideal due to the low pulmonary accumulation and targeting of therapeutics. Here,

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Mitochondrial apoptosis induced by MNAT1 in laryngeal squamous cell carcinoma cells reverses drug resistance.

Cell type: T cell | Technique: EdU proliferation, flow cytometry, western blot, wound healing | Disease/area: cancer | Translational oncology (2025)

Laryngeal squamous cell carcinoma (LSCC), the predominant histological subtype of laryngeal cancer with a poor diagnosis, requires further exploration of its molecular mechanisms and potential therapeutic targets. The expression of MNAT1 in LSCC was detected b

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cJun-N-terminal kinase activity and mitosis perturbation drive the 2-methoxyestradiol-mediated enhancement of viral oncolysis by Epizootic Hemorrhagic Disease Virus-Tel Aviv University.

Cell type: cancer cell, cell line, fibroblast | Technique: general | Disease/area: cancer, infectious disease, skin disease | Scientific reports (2025)

Oncolytic viruses (OVs) are promising cancer therapies whose efficacy is restricted by tumor heterogeneity and monotherapy limitations. We investigated combining the oncolytic orbivirus Epizootic Hemorrhagic Disease Virus -Tel Aviv University (EHDV-TAU) with t

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Tet Transgene Activation is Disrupted in Lipogenic Triple Negative Breast Cancer Cells.

Cell type: T cell, adipocyte, cancer cell, cell line, epithelial | Technique: general | Disease/area: cancer | ACS synthetic biology (2025)

A critical challenge for mammalian cell engineering is the unexpected response of transgenes to native transcriptional regulation pathways. One transgene can show different levels of expression at different genomic sites, in different cell types, and under dif

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TMBIM6 promotes glioma progression according to integrated bioinformatics and experimental evidence.

Cell type: macrophage | Technique: general | Disease/area: cancer | Scientific reports (2025)

TMBIM6, a transmembrane BAX inhibitor motif containing 6, located in the endoplasmic reticulum, is linked to various cellular processes and cancer progression. Previous investigations showed a substantial association between TMBIM6 and survival in patients dia

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Arylsulfatase B induces melanoma apoptosis by the ubiquitin ligase COP1.

Cell type: cell line | Technique: EdU proliferation | Disease/area: cancer | The Journal of biological chemistry (2025)

Previous experiments in the syngeneic, murine, and subcutaneous model of malignant melanoma and human melanoma cells showed that treatment by recombinant human (rh) Arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) markedly reduced the volume of tumors

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Repeated Low-Level Inflammatory Challenge Leads to Alterations in the TNF-CXCL10 Signalling Pathway in Mouse Cerebral Endothelial Cells In Vitro.

Cell type: cell line, endothelial | Technique: EdU proliferation, western blot | Disease/area: cancer, inflammation | Journal of neurochemistry (2025)

The mechanism by which chronic systemic inflammation contributes to cerebral endothelial dysfunction and neurological disorders is unclear, although endothelial inflammatory signalling is considered a cornerstone of this process. Here, we have performed transc

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The Interplay of SMAD4 and EMT in Oral Squamous Cell Carcinoma.

Cell type: general | Technique: general | Disease/area: cancer | Cancers (2025)

(Abstract unavailable)

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Design and synthesis of 3,4-seco-lupane triterpene-tryptamine derivatives and revealing their anti-bladder cancer mechanisms by combining TCGA and transcriptomic approaches.

Cell type: cell line, tumor cell | Technique: general | Disease/area: cancer | Scientific reports (2025)

Bladder cancer is the most common malignant tumor of the urinary tract. In this study, 90 lupane triterpene derivatives, previously synthesized in the laboratory, were systematically evaluated for their potential effects against bladder cancer by cytotoxicity

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EGFRvIII-driven microenvironmental fibroblast activation and transformation accelerate oral cancer progression via lipocalin-2/STAT3 axis.

Cell type: cell line, fibroblast, tumor cell | Technique: EdU proliferation | Disease/area: cancer | Neoplasia (New York, N.Y.) (2025)

Oral squamous cell carcinoma (OSCC) is an aggressive malignancy frequently characterized by dysregulated epidermal growth factor receptor (EGFR) signaling. Among EGFR mutation, EGFRvIII, an extracellular domain truncated form without exons 2-7, exhibits ligand

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Distinct proliferative and neuronal programmes of chromatin binding and gene activation by ASCL1 are cell cycle stage-specific.

Cell type: T cell, cell line, neuron, tumor cell | Technique: general | Disease/area: Parkinson disease, cancer | Development (Cambridge, England) (2025)

ASCL1 is a potent proneural factor with paradoxical functions during development, promoting both progenitor pool expansion and neuronal differentiation. How a single factor executes and switches between these potentially opposing functions remains to be unders

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Cancer therapy via neoepitope-specific monoclonal antibody cocktails.

Cell type: cell line, tumor cell | Technique: general | Disease/area: cancer | Cancer immunology, immunotherapy : CII (2025)

Cellular heterogeneity presents a significant challenge to cancer treatment. Antibody therapies targeting individual tumor-associated antigens can be extremely effective but are not suited for all patients and often fail against tumors with heterogeneous expre

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GLUT1-mediated HMGB1 O-GlcNAcylation drives hyperglycemia-Induced neutrophil extracellular trap networks formation via TLR4 signaling and exacerbates fibroblast inflammation.

Cell type: fibroblast | Technique: EdU proliferation | Disease/area: cancer, inflammation | Scientific reports (2025)

Neutrophil extracellular traps (NETs) exacerbate fibroblast inflammatory injury in hyperglycemic conditions, yet the role of glucose metabolism and O-linked N-acetylglucosamine (O-GlcNAc) glycosylation in this process remains unclear. Here, we investigate how

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