EVOS M5000 in Cardiovascular & Endothelial Research: Independent Studies — Wave 2

Vascular biology, endothelial function and cardiac research with the EVOS M5000. Each paper was discovered independently of Thermo Fisher's curated EVOS M5000 citations and verified to mention the EVOS M5000 Imaging System as a microscope in the full text. Paper cards link to Google Scholar, PubMed, PMC and DOI.

EVOS M5000CardiovascularEndothelialIndependentWave 2

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Intravenous rAAV9 Produces Time-Resolved Parenchymal Labeling Downstream of the Vasculature in Adult Mice.

Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Cardiovascular

EVOS M5000 Imaging System (Thermo Fisher) and viewed through a DAPI filter cube for Hoechst images and an RFP filter cube for tdTomato images. All confocal images were captured using a Leica Stellaris 5 Confoca

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Regulation of Mitophagy by Low-Intensity Pulsed Ultrasound Attenuates Endothelial Dysfunction.

Cell type: Fibroblast | Technique: Fluorescence imaging | Disease/area: Cardiovascular

Background: Diabetic vascular complications are a major cause of poor prognosis in patients with diabetes mellitus (DM). Mitophagy activation is a potential therapeutic target for type 2 diabetes mellitus (T2DM), but the role of low-intensity pulsed ultrasound (LIPUS) in this context remains unclear. Methods: The biological effects of LIPUS on endothelial cells under high gluco

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Endothelial cell source dictates the expression and release of fibrinolytic markers in a proinflammatory environment.

Cell type: Endothelial | Technique: Fluorescence imaging | Disease/area: Cardiovascular

EVOS M5000 fluorescent microscope (Thermo Fisher Scientific) with an oil-immersion 60× objective lens.</p></section><section id="sec2.4"><h3 class="pmc_sec_title">2.4. Plasma clot lysis assay</h3>

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Caspase-6 Is a Non-Apoptotic Effector of Shear-Induced Morphological Adaptation in Pulmonary Artery Endothelial Cells In Vitro.

Cell type: Endothelial | Technique: Fluorescence imaging | Disease/area: Cardiovascular

EVOS M5000, Invitrogen, Waltham, MA, USA), and cell orientation/elongation was quantified using a custom MATLAB R2022a (MathWorks, Natick, MA, USA) script, with at least 900 cells analyzed per condition. Cells

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Synergistic Combination of Additive One- and Two-Photon Polymerization Printing Methods to Fabricate 3D Microstructured Perfusable Angiogenesis-on-a-Chip Systems.

Cell type: Endothelial | Technique: Fluorescence imaging | Disease/area: Cardiovascular

Tissue engineering, and in particular the development of organ-on-a-chip (OOC) models, holds significant promise for advancing personalized medicine and reducing the use of animal models. The integration of microfluidics and advanced biomaterials in OOC systems provides controlled microenvironments and fosters the creation of physiologically relevant tissue models. A critical a

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Identification of pathological CD133+ endothelial cells in venous malformations.

Cell type: Endothelial | Technique: Fluorescence imaging | Disease/area: Cardiovascular

Venous malformations (VMs) are congenital malformations of the venous system. Histologically, they are composed of dilated vascular channels. Prior studies have demonstrated that CD31 + endothelial cells (ECs) in VMs have pathogenic variants. Recent studies by our group found that the EC progenitor marker, CD133+, was expressed on VM endothelium in patient tissues. We hypothesi

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