EVOS M5000 in Infectious Disease & Immunology Research — Wave 3
Peer-reviewed studies using the EVOS M5000 Imaging System for bacteria, viruses, COVID-19, host-pathogen interactions and immune cells. Each entry was discovered independently of Thermo Fisher's curated EVOS M5000 citations and verified to mention the EVOS M5000 Imaging System as a microscope in the full text. Paper cards link to Google Scholar, PubMed, PMC and DOI when available.
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Antimicrobial efficacy and cytotoxic assessment of plasma-activated water generated by a dielectric barrier discharge microbubble system.
Cell type: general | Technique: general | Disease/area: infectious disease | Frontiers in microbiology (2026)
The growing threat of antimicrobial resistance has intensified the search for alternative disinfection strategies. Plasma-activated water (PAW), enriched with reactive oxygen and nitrogen species (RONS), has emerged as a promising non-antibiotic antimicrobial
Google Scholar | PubMed | PMC | DOI
Mammarenaviruses depend on endogenous fatty acid synthesis in cell culture systems.
Cell type: T cell, cell line | Technique: EdU proliferation | Disease/area: infectious disease | Journal of lipid research (2026)
Lassa virus (LASV) and lymphocytic choriomeningitis virus (LCMV) are Old World mammarenaviruses that, like all viruses, rely on host-derived biological molecules to complete their replication cycle. Identifying host factors essential for mammarenavirus replica
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Immune protection in chickens via lipid nanoparticle-encapsulated VP2 DNA vaccine against very virulent infectious bursal disease virus.
Cell type: general | Technique: general | Disease/area: infectious disease | Poultry science (2026)
Infectious bursal disease (IBD), caused by infectious bursal disease virus (IBDV), is an acute and highly contagious avian infection that primarily causes severe immunosuppression in chickens. Since the 1980s, very virulent IBDV (vvIBDV) has triggered a global
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Glycosylated NS3/NS3A protein of bluetongue virus facilitates efficient viral egress via lipid raft anchoring.
Cell type: cell line | Technique: general | Disease/area: infectious disease | Journal of virology (2026)
Bluetongue virus (BTV) is an economically important arbovirus of ruminants worldwide. The nonstructural glycoprotein NS3/NS3A contains a uniquely conserved N-linked glycosylation site at Asn
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Genome-wide CRISPR screening identifies Annexin A1 as a facilitator of porcine astrovirus entry.
Cell type: T cell, epithelial | Technique: CRISPR, EdU proliferation | Disease/area: infectious disease | PLoS pathogens (2026)
Porcine astrovirus (PAstV) is an important and widespread pathogen in swine, linked to diarrheal outbreaks and extraintestinal disease. How PAstV enters host cells has remained unclear, and no cellular factor has been defined for PAstV entry. Here, a genome-wi
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DNA damage induced by HIV-1 Vpr triggers epigenetic remodeling and transcriptional programs to enhance virus transcription and latency reactivation.
Cell type: general | Technique: general | Disease/area: infectious disease | PLoS biology (2026)
Hijacking of host DNA damage repair (DDR) pathways to facilitate virus replication is broadly conserved amongst diverse viral families. It has been well established that the HIV-1 accessory protein Vpr induces constitutive DDR signaling and G2/M cell cycle arr
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In Vitro Assessment of Ventricular Catheters with a Multilayered Fibrous Web to Prevent Cellular Occlusion.
Cell type: T cell | Technique: EdU proliferation | Disease/area: infectious disease | ACS biomaterials science & engineering (2026)
Hydrocephalus management generally requires the implantation of a cerebrospinal fluid (CSF) shunt system that includes a ventricular catheter, a mechanical valve to regulate CSF flow, and a distal catheter that diverts the CSF to another site in the body, most
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Proof of concept: targeted protein degradation of the stress granules component G3BP1 as an antiviral strategy against norovirus infection.
Cell type: general | Technique: EdU proliferation, knockout | Disease/area: infectious disease | Antimicrobial agents and chemotherapy (2026)
Human norovirus (HNoV) is a major cause of gastroenteritis worldwide, for which no antiviral therapies exist to date. Previously, our lab has demonstrated that both HNoV and murine norovirus (MNV1) are highly dependent on the expression of the Ras-GTPase-activ
Google Scholar | PubMed | PMC | DOI
Recombinant vaccinia vectored ASFV vaccine enhances swine survival against genotype II challenge.
Cell type: T cell | Technique: general | Disease/area: infectious disease, inflammation | NPJ vaccines (2026)
The African Swine Fever Virus (ASFV) poses a major threat to global livestock production by infecting both domestic and wild pigs, causing significant economic loss. Despite promising protective results observed with live attenuated viruses, the safety concern
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Design and
Cell type: general | Technique: general | Disease/area: infectious disease | Materials today. Bio (2026)
RNA interference (RNAi) is a powerful tool for post-transcriptional gene silencing, yet its clinical translation remains limited by the lack of safe and efficient delivery systems. In this study, we evaluated the potential of plant virus-like particles (VLPs),
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Complete transition from chromosomal to cytoplasmic sex determination during prolonged Wolbachia symbiosis.
Cell type: general | Technique: general | Disease/area: infectious disease | Nature communications (2026)
Wolbachia infection causes male-specific death in Ostrinia furnacalis, but its removal from infected strains results in female-specific death instead of restoring 1:1 sex ratio, suggesting that cytoplasmic Wolbachia, not the host genome, primarily determines f
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Protection against lethal canine distemper virus infection by a dual epitope-targeting synthetic antibody.
Cell type: general | Technique: general | Disease/area: infectious disease | Nature communications (2026)
Despite vaccine availability, the morbilliviruses measles virus and canine distemper virus (CDV) are still causing major health impairments in human and animal populations. Here, we identified two potent, neutralizing single domain antibodies directed against
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Structural and functional characterization of the antigenicity of influenza A virus hemagglutinin subtype H15.
Cell type: general | Technique: general | Disease/area: infectious disease | Cell reports (2026)
Avian H15 influenza viruses are closely related to H7 viruses, but only 22 H15 sequences have been reported since 1987, suggesting both rarity and minimal antigenic variation. Here, we characterized a panel of mouse monoclonal antibodies (mAbs) raised against
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Bacteria-responsive DNAgel system for targeted delivery of photothermally enhanced MXene/MoS
Cell type: general | Technique: general | Disease/area: bone disease, infectious disease | Bioactive materials (2026)
Pyogenic osteomyelitis (POM) presents significant clinical challenges due to persistent infections and impaired bone regeneration. Here, we developed a bacteria-responsive MXene/MoS
Google Scholar | PubMed | PMC | DOI
Transparent Multifunctional Wearable Strain Sensor With Self-Healing and Antibacterial Capabilities for Human Motion Detection.
Cell type: fibroblast | Technique: general | Disease/area: infectious disease, skin disease | Advanced healthcare materials (2026)
Wearable strain sensors are highly desirable due to their increasing applications in smart electronic skins and healthcare monitoring systems. Nevertheless, simultaneously integrating high stretchability, sensing linearity, stable operation under sub-zero temp
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Antimycin A inhibits alpha-herpesvirus replication by disrupting the formation of pyrimidinosomes.
Cell type: general | Technique: general | Disease/area: infectious disease | Journal of advanced research (2026)
Alpha-herpesvirus poses significant health risks to humans and challenges to animal husbandry. Currently, the clinically approved antiviral drug Acyclovir exhibits limitations, including drug resistance and adverse effects. The development of broad-spectrum an
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Assessment of the phi6 lysis system using genetic complementation and heterologous expression in
Cell type: general | Technique: general | Disease/area: infectious disease | Frontiers in microbiology (2025)
The RNA cystovirus phi6 represents a unique evolutionary outlier, encoding a holin and endolysin similar to tailed phages, yet lacking an identified gene for outer membrane disruption. In this study, we investigated the phi6 lysis system using genetic compleme
Google Scholar | PubMed | PMC | DOI
Keratin Additive for Cellular Adhesion in Transcutaneous Prosthetics.
Cell type: general | Technique: general | Disease/area: infectious disease, skin disease | Journal of tissue engineering and regenerative medicine (2025)
The dermal barrier is widely considered the body's first line of defense against most foreign bodies, protecting it from both moisture loss and bacterial invasion. However, when the skin is ruptured for long-term medical interventions (e.g., transcutaneou
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Molecular basis of ApoER2-mediated Semliki Forest virus entry.
Cell type: HEK293 | Technique: general | Disease/area: infectious disease | Nature communications (2025)
The very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) serve as entry receptors for the Semliki Forest virus (SFV). VLDLR interacts with the SFV E1 domain III (DIII) through multiple LDLR class A (LA) domains. However, the A
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Structural insights into mechanisms of zinc scavenging by the Candida albicans zincophore Pra1.
Cell type: general | Technique: general | Disease/area: infectious disease, inflammation | Nature communications (2025)
Candida albicans causes over 400,000 life-threatening, and an additional half a billion of mucosal infections annually. In response to infection, the host limits essential micronutrient availability, including zinc, to restrict growth of the invading pathogen.
Google Scholar | PubMed | PMC | DOI
Pseudovirus-Based Neutralization Assays as Customizable and Scalable Tools for Serological Surveillance and Immune Profiling.
Cell type: HEK293 | Technique: EdU proliferation, GFP | Disease/area: COVID-19, bone disease, infectious disease | Pathogens (Basel, Switzerland) (2025)
Neutralizing antibodies (nAbs) are key indicators of protection against SARS-CoV-2, and their measurement remains essential for monitoring vaccine responses and population immunity. While the plaque reduction neutralization test (PRNT) is the gold standard, it
Google Scholar | PubMed | PMC | DOI
Cytokine responses to respiratory syncytial virus infection in well-differentiated infant nasal epithelial cell cultures.
Cell type: T cell, epithelial | Technique: general | Disease/area: infectious disease | Clinical and experimental vaccine research (2025)
Differentiated airway epithelial cell cultures closely mimic the in vivo airways. We compared the structure and cytokine response of well-differentiated human nasal epithelial (HNE) cells obtained from healthy infants (iHNE) and adults (aHNE). Human bronchial
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Breaking the reproducibility barrier with standardized protocols for plant-microbiome research.
Cell type: general | Technique: general | Disease/area: infectious disease | PLoS biology (2025)
Inter-laboratory replicability is crucial yet challenging in microbiome research. Leveraging microbiomes to promote soil health and plant growth requires understanding underlying molecular mechanisms using reproducible experimental systems. In a global collabo
Google Scholar | PubMed | PMC | DOI
Metavac-RSV mucosal bivalent vaccine candidate protects cotton rats against pneumoviruses and is produced using serum-free cell culture in bioreactor.
Cell type: general | Technique: EdU proliferation | Disease/area: infectious disease | NPJ vaccines (2025)
Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are the main etiologic agents of viral bronchiolitis and pneumonia in children and the elderly. As live-attenuated vaccines (LAV) can stimulate robust mucosal and cellular responses, we previou
Google Scholar | PubMed | PMC | DOI
Characterization of the glycoproteins of fish and amphibian influenza B-like viruses.
Cell type: general | Technique: general | Disease/area: infectious disease | Science advances (2025)
Influenza-like virus sequences previously identified in fish and amphibians cluster as a sister clade of influenza B viruses but remain largely uncharacterized. We demonstrate that salamander influenza-like virus (SILV) hemagglutinin (HA) is functionally diver
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A broadly neutralizing antibody recognizes a unique epitope with a signature motif common across coronaviruses.
Cell type: general | Technique: general | Disease/area: COVID-19, infectious disease | Nature communications (2025)
Cross-reactive antibodies targeting multiple epitopes have been identified in Sarbecoviruses, but the precise molecular mechanism(s) behind the crossreactivity remain poorly understood. Here, we isolate 3D1, a broadly neutralizing antibody (bnAb) derived from
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Rapid generation of HCoV-229E and HCoV-OC43 reporter viruses and replicons for antiviral research.
Cell type: general | Technique: CRISPR | Disease/area: infectious disease | Frontiers in cellular and infection microbiology (2025)
The large size of coronavirus genome, along with the instability of certain genomic sequences, makes the construction of reverse genetics for coronaviruses particularly challenging. The rapid development and application of reverse genetics systems for coronavi
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SARS-CoV-2 spike treatment and transfection impairs airway epithelial repair.
Cell type: epithelial | Technique: EdU proliferation, transfection | Disease/area: COVID-19, infectious disease, inflammation, wound healing | ERJ open research (2025)
The airway epithelium serves as a physical and immune barrier against inhaled insults. This tissue is susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and, following injury, the airway epithelium undergoes repair to restore
Google Scholar | PubMed | PMC | DOI
Octenidine effectively reduces Candida auris colonisation on human skin.
Cell type: general | Technique: EdU proliferation | Disease/area: infectious disease, skin disease, wound healing | Scientific reports (2025)
Candidozyma (formerly Candida) auris (C. auris), a WHO critical priority pathogen known for its multi-drug resistance and strong skin tropism, is posing a significant health threat. This study evaluates the efficacy of commercial octenidine-based antiseptics i
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HIV-1 infection of macrophages differentially primes NK-cell cytotoxicity and proinflammatory cytokine production.
Cell type: macrophage | Technique: general | Disease/area: infectious disease, inflammation | iScience (2025)
Natural killer (NK) cells are innate cytotoxic lymphocytes with antiviral functions explored in "shock and kill" strategies to eliminate the HIV-1 reservoir. For optimal activity against infected targets, NK cells require priming. This study examined
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Modifying Antifungal Peptides as Safe Food Preservatives.
Cell type: general | Technique: general | Disease/area: infectious disease | Journal of agricultural and food chemistry (2025)
Food loss and waste (FLW) constitute a major global concern with significant environmental and economic ramifications. A major cause of FLW is fungal contamination, leading to food spoilage. Here, we investigate the use of antimicrobial peptides (AMPs) as a ne
Google Scholar | PubMed | PMC | DOI
In vitro antiviral activities of thymol and Limonin against influenza a viruses and SARS-CoV-2.
Cell type: cell line | Technique: general | Disease/area: COVID-19, infectious disease | Scientific reports (2025)
Emerging and re-emerging respiratory viruses represent a continuing threat to human health. The pandemic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and influenza A viruses (IAVs) are co-circulating, presenting serious threats to public health
Google Scholar | PubMed | PMC | DOI
Discovery and development of a safe and efficient COVID-19 mRNA vaccine, STP2104, using a novel capping library screening method.
Cell type: general | Technique: general | Disease/area: COVID-19, infectious disease | Frontiers in immunology (2025)
Messenger RNA (mRNA) vaccines represent a critical avenue for coronavirus disease 2019 (COVID-19) prevention. We developed a COVID-19 mRNA vaccine encoding a codon-optimized full-length ancestral spike (S) protein with a signal peptide, which employs our novel
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Cas9- and Cas12a-mediated excision and replacement of the celiac disease-related α-gliadin immunogenic complex in hexaploid wheat.
Cell type: general | Technique: CRISPR, EdU proliferation | Disease/area: infectious disease | Plant biotechnology journal (2025)
Celiac disease (CD) is a chronic enteropathy affecting approximately 1% of the global population. Wheat α-gliadins are a major contributor to the autoimmune response, as they contain one of the most immunogenic peptides, the 33-mer, along with numerous variant
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Chicken interferon-induced transmembrane proteins inhibit Newcastle disease virus infection by affecting viral entry and W protein expression.
Cell type: cell line | Technique: EdU proliferation | Disease/area: infectious disease | Veterinary research (2025)
Interferon-induced transmembrane proteins (IFITMs) are essential components of the innate immune system, demonstrating potent resistance to various enveloped viruses (such as influenza, West Nile, and dengue viruses) both in laboratory settings and in living o
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Insights into growth retardation and dwarfism caused by goose parvovirus in goslings: a transcriptomic profiling study.
Cell type: fibroblast | Technique: general | Disease/area: infectious disease | Frontiers in veterinary science (2025)
Goose parvovirus (GPV) poses a significant threat to the waterfowl industry as it results in a high mortality rate and stunted growth in surviving goslings, leading to significant economic losses. We used 120 goslings and goose embryo fibroblasts inoculated wi
Google Scholar | PubMed | PMC | DOI
Cyanoexosortase B is essential for motility, biofilm formation, and scytonemin production in a filamentous cyanobacterium.
Cell type: general | Technique: general | Disease/area: infectious disease | mSphere (2025)
Exosortases are involved in trafficking proteins containing PEP-CTERM domains to the exterior of gram-negative bacterial cells. The role of these proteins in cyanobacteria, where such homologs are common, has not been defined. The filamentous cyanobacterium
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Harnessing endogenous anti-glycan antibodies using a novel, bifunctional immunotherapy to treat gram-negative bacterial infections.
Cell type: general | Technique: EdU proliferation | Disease/area: infectious disease | Journal of immunology (Baltimore, Md. : 1950) (2025)
The current array of traditional antibacterial agents targeting Gram-negative infections are failing to meet the clinical need. Here we present a novel, bifunctional immunotherapy (CTX-09) with the ability to harness endogenous anti-galactose-alpha-1,3-galacto
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Amphiphilic mPEG-PLGA copolymer nanoparticles co-delivering colistin and niclosamide to treat colistin-resistant Gram-negative bacteria infections.
Cell type: general | Technique: EdU proliferation | Disease/area: infectious disease | Communications biology (2025)
Colistin is the last line of defense against multidrug-resistant (MDR) Gram-negative bacterial infections, yet it is restricted due to high drug resistance and toxicity. The combination therapy of colistin and niclosamide exhibits excellent synergistic antibac
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A secreted helminth microRNA suppresses gastrointestinal cell differentiation required for innate immunity.
Cell type: T cell, epithelial | Technique: general | Disease/area: infectious disease | Frontiers in immunology (2025)
Pathogens have developed multiple strategies to modulate host immune defense mechanisms. Understanding how this is achieved has potential to inform novel therapeutics for diseases caused by immune dysfunction. Parasitic helminths are masters of immune evasion,
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Detection of antibodies against influenza A viruses in cattle.
Cell type: general | Technique: general | Disease/area: infectious disease | Journal of virology (2025)
Unexpected outbreaks caused by the H5N1 highly pathogenic avian influenza virus (HPAIV) in dairy cows in the United States (US) have raised significant veterinary and public health concerns. When and how the H5N1 HPAIV was introduced into dairy cows and the br
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MITD1 is a brain-specific interferon-inducible factor that inhibits flavivirus replication.
Cell type: HEK293, microglia | Technique: general | Disease/area: infectious disease | Proceedings of the National Academy of Sciences of the United States of America (2025)
West Nile virus (WNV) and Usutu virus (USUV) are closely related mosquito-borne neurotropic flaviviruses that share common transmission cycle and can infect humans. However, while human infections by WNV are widespread, infections by USUV are comparatively les
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SFTSV NSs interacts with AGO2 to regulate the RNAi pathway for viral replication.
Cell type: HEK293, cell line | Technique: GFP | Disease/area: infectious disease | Journal of virology (2025)
RNA interference (RNAi) is a posttranscriptional gene silencing mechanism acting as an antiviral defense in eukaryotes. During viral replication, intermediate double-stranded RNAs are processed into virus-derived small interfering RNAs (vsiRNAs) by the host en
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ISG15-Dependent Stabilisation of USP18 Is Necessary but Not Sufficient to Regulate Type I Interferon Signalling in Humans.
Cell type: HEK293, T cell | Technique: EdU proliferation | Disease/area: infectious disease, inflammation | European journal of immunology (2025)
Type I interferon (IFN) signalling induces the expression of several hundred IFN-stimulated genes (ISGs) that provide an unfavourable environment for viral replication. To prevent an overexuberant response and autoinflammatory disease, IFN signalling requires
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Characterizing SV40-hTERT Immortalized Human Lung Microvascular Endothelial Cells as Model System for Mechanical Stretch-Induced Lung Injury.
Cell type: cell line, endothelial | Technique: transfection | Disease/area: infectious disease | International journal of molecular sciences (2025)
Drug development for human disease relies on preclinical model systems such as human cell cultures and animal experiments before therapeutic treatments can ultimately be tested on humans in clinical studies. We here describe the generation of a novel human cel
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Single-cycle parainfluenza virus type 5 vectors for producing recombinant proteins, including a humanized anti-V5 tag antibody.
Cell type: T cell, cell line | Technique: general | Disease/area: infectious disease | The Journal of general virology (2025)
Parainfluenza virus type 5 (PIV5) can cause either persistent or acute/lytic infections in a wide range of mammalian tissue culture cells. Here, we have generated PIV5 fusion (F)-expressing helper cell lines that support the replication of F-deleted viruses. A
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Essential role of
Cell type: cell line | Technique: general | Disease/area: infectious disease | Journal of virology (2025)
Classical swine fever virus (CSFV) is a member of the genus Pestiviruses are economically significant pathogens in livestock. Although genome organization and non-structural protein functions resemble those of other
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Structural basis of different neutralization capabilities of monoclonal antibodies against H7N9 virus.
Cell type: general | Technique: general | Disease/area: infectious disease | Journal of virology (2025)
Neutralizing antibodies (nAbs) are important for the treatment of emerging viral diseases and for effective vaccine development. In this study, we generated and evaluated three nAbs (1H9, 2D7, and C4H4) against H7N9 influenza viruses and found that they differ
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DHX15 and Rig-I Coordinate Apoptosis and Innate Immune Signaling by Antiviral RNase L.
Cell type: cell line | Technique: EdU proliferation | Disease/area: infectious disease, inflammation | Viruses (2024)
During virus infection, the activation of the antiviral endoribonuclease, ribonuclease L (RNase L), by a unique ligand 2'-5'-oilgoadenylate (2-5A) causes the cleavage of single-stranded viral and cellular RNA targets, restricting protein synthesis, a
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Structural insights into Semiliki forest virus receptor binding modes indicate novel mechanism of virus endocytosis.
Cell type: general | Technique: general | Disease/area: infectious disease | PLoS pathogens (2024)
The Very Low-Density Lipoprotein Receptor (VLDLR) is an entry receptor for the prototypic alphavirus Semliki Forest Virus (SFV). However, the precise mechanisms underlying the entry of SFV into cells mediated by VLDLR remain unclear. In this study, we found th
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An Integrated Dual-Layer Heterogeneous Polycaprolactone Scaffold Promotes Oral Mucosal Wound Healing through Inhibiting Bacterial Adhesion and Mediating HGF-1 Behavior.
Cell type: epithelial, fibroblast | Technique: EdU proliferation, wound healing | Disease/area: infectious disease, inflammation, wound healing | Research (Washington, D.C.) (2024)
Recently, the high incidence of oral mucosal defects and the subsequent functional impairments have attracted widespread attention. Controlling scaffold geometry pattern has been proposed as a strategy to promote cell behavior and facilitate soft tissue repair
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Identification and Characterization of Linear Epitopes of Monoclonal Antibodies Against African Horse Sickness Virus Serotype 1 VP2 Protein.
Cell type: general | Technique: general | Disease/area: infectious disease | Viruses (2024)
African horse sickness (AHS) is an acute, fatal, contagious disease of animals of the family Equidae and is caused by infection with the African horse sickness virus (AHSV). Based on the outer capsid protein VP2, AHSV is classified into nine serotypes (AHSV-1
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Antiviral activity of cathelicidins against porcine epidemic diarrhea virus (PEDV): Mechanisms, and efficacy.
Cell type: general | Technique: EdU proliferation, GFP, flow cytometry | Disease/area: infectious disease | Virus research (2024)
Porcine epidemic diarrhea virus (PEDV) is a harmful coronavirus infecting pigs, which is resulting in substantial financial losses in the global pig industry. The lack of effective vaccines or treatments underscores the pressing need for new antiviral strategi
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Colistin-niclosamide effervescent dry suspension combats colistin-resistant Salmonella in vitro and in vivo.
Cell type: general | Technique: EdU proliferation | Disease/area: infectious disease | Poultry science (2024)
The increasing incidence of bacterial infections caused by multidrug-resistant (MDR) Gram-negative bacteria has deepened the need for new effective treatments. It has been reported that niclosamide (NIC) can restore the sensitivity of Gram-negative bacteria to
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Role of cuproptosis in mediating the severity of experimental malaria-associated acute lung injury/acute respiratory distress syndrome.
Cell type: HeLa, macrophage | Technique: EdU proliferation | Disease/area: infectious disease | Parasites & vectors (2024)
Malaria-associated acute lung injury/acute respiratory distress syndrome (MA-ALI/ARDS) is a fatal complication of Plasmodium falciparum infection that is partially triggered by macrophage recruitment and polarization. As reported, copper exposure increases the
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