EVOS M5000 in Inflammation & Immunology Research — Wave 3
Peer-reviewed papers using the EVOS M5000 Imaging System for inflammation, immune cells and immunological assays. Each entry was discovered independently of Thermo Fisher's curated EVOS M5000 citations and verified to mention the EVOS M5000 Imaging System as a microscope in the full text. Paper cards link to Google Scholar, PubMed, PMC and DOI when available.
EVOS M5000IndependentWave 3
← Back to EVOS M5000 Research Index
Keratinocytes regulate intraepithelial lymphocytes homing and mediate mucosal barrier integrity via JAK2/STAT3 signaling in oral lichen planus.
Cell type: T cell, epithelial, keratinocyte | Technique: EdU proliferation | Disease/area: inflammation | Frontiers in immunology (2026)
Oral lichen planus (OLP) is a common T-cell-mediated inflammatory disease affecting the oral mucosa. Intraepithelial lymphocytes (IELs), a unique subset of T cells, play a crucial role in regulating mucosal immune responses. However, the mechanisms by which ke
Google Scholar | PubMed | PMC | DOI
Taming autoimmunity: Alpha-1 antitrypsin overexpressing mesenchymal stromal cells promote regulatory T cell crosstalk to reverse diabetes.
Cell type: MSC, T cell | Technique: flow cytometry | Disease/area: diabetes, inflammation | Molecular therapy : the journal of the American Society of Gene Therapy (2026)
Mesenchymal stem/stromal cell (MSC) therapy holds promise as a therapeutic option in diabetes treatment. Anti-inflammatory and immunomodulatory activities are enhanced when MSCs are engineered to overexpress alpha-1 antitrypsin (AAT-MSCs). Because a single inf
Google Scholar | PubMed | PMC | DOI
Mucopenetrative Lipid-Polymer nanoparticles show Potent Anti-Inflammatory activity in a human Lung-on-Chip model.
Cell type: T cell, cell line, epithelial, fibroblast | Technique: EdU proliferation | Disease/area: fibrosis, inflammation | International journal of pharmaceutics (2026)
Airway mucus presents a significant barrier to inhaled drug delivery, particularly for nanoparticle-based interventions, with this barrier exacerbated in chronic respiratory diseases (CRDs) due to hyperviscous secretions and persistent inflammation. In this st
Google Scholar | PubMed | PMC | DOI
Senolytics, dasatanib plus quercetin, reduce kidney inflammation, senescent cell abundance, and injury while restoring geroprotective factors in murine diabetic kidney disease.
Cell type: T cell, endothelial, epithelial, macrophage | Technique: EdU proliferation | Disease/area: diabetes, fibrosis, inflammation | EBioMedicine (2026)
Maladaptive inflammation and cellular senescence contribute to diabetic kidney disease (DKD) pathogenesis and represent important therapeutic targets. Senolytic agents selectively remove senescent cells and reduce inflammation-associated tissue damage. In our
Google Scholar | PubMed | PMC | DOI
Sbno2-mediated tissue-resident alveolar macrophages: a novel therapeutic axis for sepsis-induced acute lung injury.
Cell type: epithelial, macrophage | Technique: EdU proliferation, knockout | Disease/area: inflammation | Cell death discovery (2026)
Sepsis-induced acute lung injury (ALI) is a critical clinical condition characterized by severe inflammation and alveolar epithelial barrier disruption, with limited effective treatments. Our study investigates the role of Sbno2-expressing tissue-resident alve
Google Scholar | PubMed | PMC | DOI
Glutathione peroxidase mimic-engineered α-lactalbumin self-assembling coatings tailor immunomodulatory vascular stents for suppressing restenosis.
Cell type: endothelial | Technique: general | Disease/area: inflammation | Bioactive materials (2026)
Timely endothelial regeneration and repair after stenting is essential for enhancing vascular healing performance. This necessitates that the stent surface be capable of maintaining a positive balance or sequential regulation among thrombosis, inflammation, an
Google Scholar | PubMed | PMC | DOI
Cuproptosis-driven astrocyte reactivity exacerbates experimental cerebral malaria pathogenesis.
Cell type: HeLa | Technique: general | Disease/area: inflammation | Parasites & vectors (2025)
Cerebral malaria (CM), a lethal neurological complication of Plasmodium falciparum, is characterized by blood-brain barrier (BBB) disruption. Although astrocytes constitute essential components of the BBB neurovascular unit, their immunoregulatory functions du
Google Scholar | PubMed | PMC | DOI
Oxidative stress triggers Itch-mediated TXNIP degradation and NF-κB activation promoting chronic obstructive pulmonary disease.
Cell type: macrophage | Technique: EdU proliferation | Disease/area: inflammation | Respiratory research (2025)
Chronic inflammatory lung diseases, including chronic obstructive pulmonary disease (COPD), are characterized by pulmonary structural changes, narrowing of the small airways, and destruction of the lung parenchyma caused by prolonged inflammation. Sustained in
Google Scholar | PubMed | PMC | DOI
Type A cholesterol-dependent cytolysins translocate to the trans-Golgi network for NLRP3 inflammasome activation.
Cell type: HEK293, macrophage | Technique: knockout | Disease/area: inflammation | Nature immunology (2025)
Cholesterol-dependent cytolysins (CDCs) constitute the largest group of pore-forming toxins and serve as critical virulence factors for diverse pathogenic bacteria. Several CDCs are known to activate the NLRP3 inflammasome, although the mechanisms are unclear.
Google Scholar | PubMed | PMC | DOI
Anemoside B4 targets RAGE to attenuate ferroptosis in sepsis-induced acute lung injury.
Cell type: general | Technique: EdU proliferation | Disease/area: arthritis, inflammation | Frontiers in pharmacology (2025)
Anemoside B4 (AB4), a major bioactive saponin isolated from the roots of To explore the therapeutic mechanism of AB4 in SALI, an integrated approach was employed, combining network pharmacology, molecular dynamics simulation, surface plasmon resonance (SPR) a
Google Scholar | PubMed | PMC | DOI
MK2 Inhibition as a Novel Treatment for Fibrosis in Primary Sclerosing Cholangitis via an IL-22-Dependent Mechanism.
Cell type: fibroblast | Technique: EdU proliferation, knockout | Disease/area: fibrosis, inflammation, liver disease | Cells (2025)
Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by bile duct inflammation and fibrosis, leading to cirrhosis and liver failure. Current therapies are limited to symptom management, with no approved treatments targeting fibrosis. W
Google Scholar | PubMed | PMC | DOI
Bioactive lipid mediator class switching regulates myogenic cell progression and muscle regeneration.
Cell type: T cell, myoblast | Technique: knockout | Disease/area: inflammation | Nature communications (2025)
The muscle stem cell niche is well-described as influencing myogenic cell fate decision; however, the intrinsic mechanisms driving muscle stem cell progression during myogenesis are not yet fully elucidated. Here, we demonstrate that bioactive lipid class swit
Google Scholar | PubMed | PMC | DOI
Copine-6 is a TRPM3 escort protein controlling the sensitivity of sensory neurons to noxious heat.
Cell type: neuron | Technique: EdU proliferation, knockout | Disease/area: inflammation | The EMBO journal (2025)
Copine-6 is a calcium-sensitive phospholipid-binding protein of the evolutionarily conserved Copine family. In the central nervous system, Copine-6 regulates function of some neurotransmitter receptors and structural plasticity of dendritic spines, influencing
Google Scholar | PubMed | PMC | DOI
Decoding hippocampal subfield and glial responses in ischemia using single-cell transcriptomics.
Cell type: microglia | Technique: EdU proliferation | Disease/area: inflammation | Journal of translational medicine (2025)
Stroke affects more than 12 million individuals worldwide annually, leading to lasting physical and cognitive impairments. The peri-infarct environment in the central nervous system, comprising glial and blood vessel cells, contributes to stroke progression. T
Google Scholar | PubMed | PMC | DOI
Engineering a Human-Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune Modulation.
Cell type: epithelial | Technique: general | Disease/area: inflammation | Advanced healthcare materials (2025)
Tissue engineering offers new hope for treating biliary defects. Several scaffolds have been proposed, but their properties have not been fully investigated. In this study, the design, fabrication, and characterization of a novel common bile duct (CBD)-like pr
Google Scholar | PubMed | PMC | DOI
IL-19 Is a Novel Lymphangiocrine Factor Inducing Lymphangiogenesis and Lymphatic Junctional Regulation.
Cell type: endothelial | Technique: immunocytochemistry, knockout | Disease/area: inflammation | Arteriosclerosis, thrombosis, and vascular biology (2025)
The lymphatic system functions by removing fluid, macromolecules, and immune cells to maintain tissue homeostasis. The structural organization of junctional protein complexes is vital to lymphatic function where initial lymphatics have permeable button junctio
Google Scholar | PubMed | PMC | DOI
CCN2 Activates Cellular Senescence Leading to Kidney Fibrosis in Folic Acid-Induced Experimental Nephropathy.
Cell type: endothelial, epithelial | Technique: knockout | Disease/area: fibrosis, inflammation | International journal of molecular sciences (2025)
Cellular communication network factor 2 (CCN2, also known as CTGF) is a complex protein that regulates numerous cellular functions. This biomolecule exhibits dual functions, depending on the context, and can act as a matricellular protein or as a growth factor
Google Scholar | PubMed | PMC | DOI
Wheat germ agglutinin-nanoparticles encapsulating itacitinib target and suppress pro-inflammatory slan+ monocytes.
Cell type: general | Technique: EdU proliferation, flow cytometry | Disease/area: inflammation | Nanomedicine (London, England) (2025)
6-sulfoLacNAc (slan)+ monocytes, a non-classical monocyte subset, play a pro-inflammatory role in autoimmune diseases like systemic lupus erythematosus (SLE). This study evaluates the therapeutic potential of itacitinib (ITA) encapsulated in wheat germ aggluti
Google Scholar | PubMed | PMC | DOI
Benzydamine rescues ethanol-induced teratogenesis in zebrafish FASD model.
Cell type: macrophage | Technique: general | Disease/area: inflammation | Scientific reports (2025)
Fetal alcohol spectrum disorders (FASD) are a group of physical, behavioral, and cognitive impairments caused by ethanol exposure during pregnancy. Zebrafish have emerged as a useful model for researching FASD and its variants in recent years. Oxidative stress
Google Scholar | PubMed | PMC | DOI
Adipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in mice.
Cell type: adipocyte | Technique: EdU proliferation | Disease/area: inflammation, obesity | iScience (2025)
Six-transmembrane protein of prostate 4 (Steap4), highly expressed in adipose tissue, is associated with metabolic homeostasis. Dysregulated adipose and mitochondrial metabolism contributes to obesity, highlighting the need to understand their interplay. Wheth
Google Scholar | PubMed | PMC | DOI
Enhancement of renal fibrosis in PHF20 transgenic mice.
Cell type: general | Technique: general | Disease/area: fibrosis, inflammation | Toxicological research (2025)
Plant homeodomain finger protein 20 (PHF20) plays a crucial role in various biological processes, but its involvement in renal fibrosis remains unclear. This study investigated the role of PHF20 in renal fibrosis using a unilateral ureteral obstruction (UUO) m
Google Scholar | PubMed | PMC | DOI
Protein hydrolysates from
Cell type: general | Technique: EdU proliferation, qPCR | Disease/area: inflammation | Animal cells and systems (2025)
Insect protein hydrolysates (PH) are emerging as valuable compounds with biological activity. The aim of the present study was to assess the potential cytoprotective effects of PH from the Black Soldier Fly (BPH, in the range 0.1-0.5 mg/mL) against inflammator
Google Scholar | PubMed | PMC | DOI
An immunoregulatory and metabolism-improving injectable hydrogel for cardiac repair after myocardial infarction.
Cell type: cardiomyocyte | Technique: general | Disease/area: fibrosis, inflammation | Regenerative biomaterials (2025)
The hypoxia microenvironment post-myocardial infarction (MI) critically disturbs cellular metabolism and inflammation response, leading to scarce bioenergy supplying, prolonged inflammatory phase and high risk of cardiac fibrosis during cardiac restoration. He
Google Scholar | PubMed | PMC | DOI
Dysregulation of protein degradation and alteration of secretome in α-synuclein-exposed astrocytes: implications for dopaminergic neuronal dysfunction.
Cell type: SH-SY5Y, cell line, iPSC, neuron | Technique: EdU proliferation, flow cytometry | Disease/area: inflammation | Cell communication and signaling : CCS (2024)
A key factor in the propagation of α-synuclein pathology is the compromised protein quality control system. Variations in membrane association and astrocytic uptake between different α-synuclein forms suggest differences in exocytosis or membrane cleavage, pot
Google Scholar | PubMed | PMC | DOI
Insights into the Identification of iPSC- and Monocyte-Derived Macrophage-Polarizing Compounds by AI-Fueled Cell Painting Analysis Tools.
Cell type: T cell, iPSC, macrophage | Technique: general | Disease/area: inflammation | International journal of molecular sciences (2024)
Macrophage polarization critically contributes to a multitude of human pathologies. Hence, modulating macrophage polarization is a promising approach with enormous therapeutic potential. Macrophages are characterized by a remarkable functional and phenotypic p
Google Scholar | PubMed | PMC | DOI
Evaluation of the Efficacy of a Full-Spectrum Low-THC
Cell type: cell line, microglia, neuron | Technique: general | Disease/area: inflammation | Biomolecules (2024)
Evidence has accumulated that
Google Scholar | PubMed | PMC | DOI
Comparative evaluation of the modulatory role of 1,25-dihydroxy-vitamin D
Cell type: cell line, epithelial | Technique: general | Disease/area: inflammation | Journal of animal science and biotechnology (2024)
The use of conventional two-dimensional (2D) culture of the porcine intestinal epithelial cell (IEC) line IPEC-J2 in animal nutrition research has the disadvantage that IEC function is studied under unphysiological conditions, which limits the ability of trans
Google Scholar | PubMed | PMC | DOI
Antisecretory Factor 16 (AF16): A Promising Avenue for the Treatment of Traumatic Brain Injury-An In Vitro Model Approach.
Cell type: cell line, neuron | Technique: general | Disease/area: inflammation | Journal of molecular neuroscience : MN (2024)
Traumatic brain injury (TBI) is caused by an external mechanical force to the head, resulting in abnormal brain functioning and clinical manifestations. Antisecretory factor (AF16) is a potential therapeutic agent for TBI treatment due to its ability to inhibi
Google Scholar | PubMed | PMC | DOI
A novel small molecule screening assay using normal human chondrocytes toward osteoarthritis drug discovery.
Cell type: fibroblast | Technique: general | Disease/area: arthritis, inflammation | PloS one (2024)
Osteoarthritis (OA) is the most common form of arthritis and a leading cause of pain and disability in adults. A central feature is progressive cartilage degradation and matrix fragment formation driven by the excessive production of matrix metalloproteinases
Google Scholar | PubMed | PMC | DOI
Human dental pulp stem cells modulate pro-inflammatory macrophages both through cell-to-cell contact and paracrine signaling.
Cell type: macrophage | Technique: EdU proliferation, immunofluorescence | Disease/area: arthritis, inflammation | Frontiers in immunology (2024)
Macrophages play a key role in most of the inflammatory diseases such as Rheumatoid Arthritis (RA), but the mechanism underlying their pathogenesis is still under study. Among stem cells, human dental pulp stem cells (hDPSCs) have attracted attention due to th
Google Scholar | PubMed | PMC | DOI
Reactive Oxygen Species-Responsive Chitosan-Bilirubin Nanoparticles Loaded with Statin for Treatment of Cerebral Ischemia.
Cell type: general | Technique: EdU proliferation | Disease/area: inflammation | Biomaterials research (2024)
Cerebral ischemia impairs blood circulation, leading to elevated reactive oxygen species (ROS) production. A ROS-responsive delivery of drugs can enhance the therapeutic efficacy and minimize the side effects. There is insufficient evidence on the impact of RO
Google Scholar | PubMed | PMC | DOI
Chlorination of epithelial tight junction proteins by neutrophil myeloperoxidase promotes barrier dysfunction and mucosal inflammation.
Cell type: epithelial | Technique: knockout | Disease/area: inflammation | JCI insight (2024)
Neutrophils (polymorphonuclear leukocytes, PMNs) comprise a major component of the immune cell infiltrate during acute mucosal inflammation and have an important role in molding the inflammatory tissue environment. While PMNs are essential to clearance of inva
Google Scholar | PubMed | PMC | DOI
Oligodendrocyte precursor cell-derived exosomes combined with cell therapy promote clinical recovery by immunomodulation and gliosis attenuation.
Cell type: neuron | Technique: EdU proliferation, flow cytometry, immunocytochemistry, immunohistochemistry | Disease/area: inflammation | Frontiers in cellular neuroscience (2024)
Multiple sclerosis is a chronic inflammatory disease of the central nervous system characterized by autoimmune destruction of the myelin sheath, leading to irreversible and progressive functional deficits in patients. Pre-clinical studies involving the use of
Google Scholar | PubMed | PMC | DOI
Arachidonic acid metabolism regulates the development of retinopathy of prematurity among preterm infants.
Cell type: general | Technique: EdU proliferation | Disease/area: inflammation | Journal of neurochemistry (2024)
Extremely preterm infants are at risk of developing retinopathy of prematurity (ROP), characterized by neovascularization and neuroinflammation leading to blindness. Polyunsaturated fatty acid (PUFA) supplementation is recommended in preterm infants to lower t
Google Scholar | PubMed | PMC | DOI
Yishen Jiangzhuo decoction attenuates cisplatin‑induced acute kidney injury by inhibiting inflammation, oxidative stress and apoptosis through the TNF signal pathway.
Cell type: epithelial | Technique: EdU proliferation, immunofluorescence, western blot | Disease/area: inflammation | Experimental and therapeutic medicine (2024)
The present study aimed to investigate the therapeutic effects and mechanisms of Yishen Jiangzhuo decoction (YSJZD) in a mouse model of cisplatin-induced acute kidney injury (AKI). The mice were divided into the NC, cisplatin and cisplatin + YSJZD groups. A co
Google Scholar | PubMed | PMC | DOI
Mesenchymal Stromal Cell (MSC) Functional Analysis-Macrophage Activation and Polarization Assays.
Cell type: macrophage | Technique: general | Disease/area: inflammation | Bio-protocol (2024)
Stem cell-based therapies have evolved to become a key component of regenerative medicine approaches to human pathologies. Exogenous stem cell transplantation takes advantage of the potential of stem cells to self-renew, differentiate, home to sites of injury,
Google Scholar | PubMed | PMC | DOI
MiR-148a-3p/SIRT7 Axis Relieves Inflammatory-Induced Endothelial Dysfunction.
Cell type: endothelial | Technique: general | Disease/area: inflammation | International journal of molecular sciences (2024)
In endothelial cells, miR-148a-3p is involved in several pathological pathways, including chronic inflammatory conditions. However, the molecular mechanism of miR-148a-3p in endothelial inflammatory states is, to date, not fully elucidated. To this end, we inv
Google Scholar | PubMed | PMC | DOI
Disease phenotypic screening in neuron-glia cocultures identifies blockers of inflammatory neurodegeneration.
Cell type: microglia, neuron | Technique: general | Disease/area: inflammation | iScience (2024)
Neuropathology is often mediated by interactions between neurons and glia that cannot be modeled by monocultures. However, cocultures are difficult to use and analyze for high-content screening. Here, we perform compound screening using primary neuron-glia cul
Google Scholar | PubMed | PMC | DOI
Radical-Generating Activity, Phagocytosis, and Mechanical Properties of Four Phenotypes of Human Macrophages.
Cell type: T cell, macrophage | Technique: general | Disease/area: inflammation | International journal of molecular sciences (2024)
Macrophages are the major players and orchestrators of inflammatory response. Expressed proteins and secreted cytokines have been well studied for two polar macrophage phenotypes-pro-inflammatory M1 and anti-inflammatory regenerative M2, but little is known ab
Google Scholar | PubMed | PMC | DOI
The Role of Reactive Oxygen Species, Inflammation, and Endoplasmic Reticulum Stress Response in the Finasteride Protective Effect against Benign Prostate Hyperplasia.
Cell type: general | Technique: EdU proliferation | Disease/area: inflammation | The world journal of men's health (2024)
Benign prostate hyperplasia (BPH) is a common age-related chronic condition. Its pathogenesis involves androgen imbalance, inflammation, oxidative stress, and endoplasmic reticulum (ER) stress. This study aims to assess the protective effect of finasteride, a
Google Scholar | PubMed | PMC | DOI
Oral Galvanism Side Effects: Comparing Alloy Ions and Galvanic Current Effects on the Mucosa-like Model.
Cell type: cell line, keratinocyte | Technique: general | Disease/area: inflammation | Journal of functional biomaterials (2023)
The interaction of different dental alloys with the oral environment may cause severe side effects (e.g., burning sensation, inflammatory reactions, carcinogenesis) as a result of oral galvanism. However, the pathogenesis of side effects associated with oral g
Google Scholar | PubMed | PMC | DOI
Effects of crude protein and non-essential amino acids on growth performance, blood profile, and intestinal health of weaned piglets.
Cell type: general | Technique: general | Disease/area: inflammation | Frontiers in veterinary science (2023)
This study investigated the effect of crude protein (CP) and non-essential amino acid (NEAA) supplementation on the growth performance, blood profile, intestinal morphology, mRNA relative abundance of inflammatory and antioxidant markers, and tight junction pr
Google Scholar | PubMed | PMC | DOI
Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes.
Cell type: general | Technique: EdU proliferation | Disease/area: arthritis | Aging (2023)
While advanced age is widely recognized as the greatest risk factor for osteoarthritis (OA), the biological mechanisms behind this connection remain unclear. Previous work has demonstrated that chondrocytes from older cadaveric donors have elevated levels of D
Google Scholar | PubMed | PMC | DOI
Xuebijing Injection Attenuates Heat Stroke-Induced Brain Injury through Oxidative Stress Blockage and Parthanatos Modulation via PARP-1/AIF Signaling.
Cell type: T cell, endothelial, neuron | Technique: EdU proliferation | Disease/area: inflammation | ACS omega (2023)
Heat stroke (HS) is a potentially fatal acute condition caused by an interplay of complex events including inflammation, endothelial injury, and coagulation abnormalities that make its pharmacological treatment a challenging problem. The traditional Chinese me
Google Scholar | PubMed | PMC | DOI
Glucocorticoid Alleviates Mechanical Stress-Induced Airway Inflammation and Remodeling in COPD via Transient Receptor Potential Canonical 1 Channel.
Cell type: general | Technique: transfection, western blot | Disease/area: inflammation | International journal of chronic obstructive pulmonary disease (2023)
Increased airway resistance and hyperinflation in chronic obstructive pulmonary disease (COPD) are associated with increased mechanical stress that modulate many essential pathophysiological functions including airway remodeling and inflammation. Our present s
Google Scholar | PubMed | PMC | DOI
Imbalance in the spinal serotonergic pathway induces aggravation of mechanical allodynia and microglial activation in carrageenan inflammation.
Cell type: microglia | Technique: immunofluorescence | Disease/area: inflammation | The Korean journal of pain (2023)
This study investigated the effect of an excess and a deficit of spinal 5-hydroxytryptamine (5-HT) on the mechanical allodynia and neuroglia activation in a rodent pain model of carrageenan inflammation. Male Sprague-Dawley rats were implanted with an intrathe
Google Scholar | PubMed | PMC | DOI
Brain Cells Release Calreticulin That Attracts and Activates Microglia, and Inhibits Amyloid Beta Aggregation and Neurotoxicity.
Cell type: macrophage, microglia, neuron | Technique: general | Disease/area: inflammation | Frontiers in immunology (2022)
Calreticulin is a chaperone, normally found in the endoplasmic reticulum, but can be released by macrophages into the extracellular medium. It is also found in cerebrospinal fluid bound to amyloid beta (Aβ). We investigated whether brain cells release calretic
Google Scholar | PubMed | PMC | DOI
Renal ROCK Activation and Its Pharmacological Inhibition in Patients With Diabetes.
Cell type: endothelial | Technique: general | Disease/area: diabetes, fibrosis, inflammation | Frontiers in pharmacology (2021)
Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase with essential roles in cytoskeletal functions. Substantial evidence implicates ROCK as a critical regulator in the inception and progression of diabetic nephropathy throu
Google Scholar | PubMed | PMC | DOI
CD226 Is Required to Maintain Megakaryocytes/Platelets Homeostasis in the Treatment of Knee Osteoarthritis With Platelet-Rich Plasma in Mice.
Cell type: T cell | Technique: general | Disease/area: arthritis | Frontiers in pharmacology (2021)
Platelet-rich plasma (PRP) is a platelet-based application used to treat osteoarthritis (OA) clinically. The co-stimulatory molecule CD226 is expressed in T cells, NK cells, and also platelets. However, exact effects of CD226 on platelets and whether its expre
Google Scholar | PubMed | PMC | DOI
Delivering progranulin to neuronal lysosomes protects against excitotoxicity.
Cell type: neuron | Technique: EdU proliferation | Disease/area: inflammation | The Journal of biological chemistry (2021)
Loss-of-function mutations in progranulin (GRN) are a major genetic cause of frontotemporal dementia (FTD), possibly due to loss of progranulin's neurotrophic and anti-inflammatory effects. Progranulin promotes neuronal growth and protects against excitot
Google Scholar | PubMed | PMC | DOI
Impact of chronic smoking on traumatic brain microvascular injury: An in vitro study.
Cell type: endothelial | Technique: immunofluorescence, western blot | Disease/area: inflammation | Journal of cellular and molecular medicine (2021)
Traumatic brain injury (TBI) is a major reason of cerebrovascular and neurological damage. Premorbid conditions such as tobacco smoking (TS) can worsen post-TBI injuries by promoting vascular endothelial impairments. Indeed, TS-induced oxidative stress (OS) an
Google Scholar | PubMed | PMC | DOI
Polyphenols Extracted from Shanxi-Aged Vinegar Inhibit Inflammation in LPS-Induced RAW264.7 Macrophages and ICR Mice via the Suppression of MAPK/NF-κB Pathway Activation.
Cell type: macrophage | Technique: general | Disease/area: inflammation | Molecules (Basel, Switzerland) (2021)
Shanxi-aged vinegar, a traditional Chinese grain-fermented food that is rich in polyphenols, has been shown to have therapeutic effects on a variety of diseases. However, there has been no comprehensive evaluation of the anti-inflammatory activity of polypheno
Google Scholar | PubMed | PMC | DOI
Controlled induction and targeted elimination of p16
Cell type: T cell | Technique: general | Disease/area: arthritis, inflammation | FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2019)
Cellular senescence is a phenotypic state that contributes to age-related diseases through the secretion of matrix-degrading and inflammatory molecules. An emerging therapeutic strategy for osteoarthritis (OA) is to selectively eliminate senescent cells by ini
Google Scholar | PubMed | PMC | DOI