EVOS M5000 in Neuroscience Research — Wave 3
Peer-reviewed studies using the EVOS M5000 Imaging System for neurons, neurodegeneration and neural models. Each entry was discovered independently of Thermo Fisher's curated EVOS M5000 citations and verified to mention the EVOS M5000 Imaging System as a microscope in the full text. Paper cards link to Google Scholar, PubMed, PMC and DOI when available.
EVOS M5000IndependentWave 3
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Microvascular pathology in the spinal cord of severe spinal muscular atrophy patients.
Cell type: endothelial, microglia, neuron | Technique: EdU proliferation | Disease/area: inflammation, neurodegenerative | Acta neuropathologica communications (2026)
Severe spinal muscular atrophy (SMA) is a life-limiting neurodegenerative disease of infancy and early childhood, caused by reduced expression of the ubiquitous survival motor neuron protein (SMN). While current therapies aim to increase SMN levels and preserv
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Intranasal delivery of DPSC-derived small extracellular vesicles-encased phloroglucinol attenuates non-motor and motor deficits and promotes neurogenesis in an in vivo rat model of Parkinson's disease.
Cell type: microglia, neuron | Technique: EdU proliferation | Disease/area: Parkinson disease, inflammation | Stem cell research & therapy (2025)
Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron degeneration in the substantia nigra pars compacta (SNpc) driven by oxidative stress, inflammation, and impaired neurogenesis. Phloroglucinol, a polyphenolic antioxidant, has demonstrat
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Aging-associated DNA methylation of LEF1 modulates inflammation and neurodegenerative pathways.
Cell type: cell line, microglia | Technique: general | Disease/area: inflammation, neurodegenerative | Frontiers in immunology (2025)
Aging is accompanied by profound changes in immune regulation and epigenetic landscapes, yet the molecular drivers underlying these alterations are not fully understood. Transcriptional profiles of peripheral blood samples from young and elderly individuals, t
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The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity.
Cell type: general | Technique: general | Disease/area: Alzheimer disease | Nature aging (2025)
Almost half of the human genome consists of retrotransposons-'parasitic' sequences that insert themselves into the host genome via an RNA intermediate. Although most of these sequences are silenced or mutationally deactivated, they can present opport
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Neuroprotective properties of transition metal dichalcogenide nanoflowers alleviate acute and chronic neurological conditions linked to mitochondrial dysfunction.
Cell type: neuron | Technique: EdU proliferation | Disease/area: Alzheimer disease, Parkinson disease | The Journal of biological chemistry (2025)
Mitochondrial dysfunction is an expected cause of etiology and progression in numerous human neurological pathologies, including stroke, Alzheimer's, and Parkinson's diseases. Therefore, a neuroprotective treatment is an urgent and unmet need. Transi
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Fibrillar tau alters cerebral endothelial cell metabolism, vascular inflammatory activation, and barrier function in vitro and in vivo.
Cell type: endothelial | Technique: EdU proliferation | Disease/area: Alzheimer disease, inflammation | Alzheimer's & dementia : the journal of the Alzheimer's Association (2025)
The presence of tau aggregates in and around the brain vasculature in Alzheimer's disease (AD) and tauopathies suggests its possible pathogenicity to cerebral endothelial cells (ECs). We used an in vitro model of the blood-brain barrier (BBB) to understan
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Tubulin-Binding Region Modulates Cholesterol-Triggered Aggregation of Tau Proteins.
Cell type: general | Technique: general | Disease/area: Alzheimer disease, neurodegenerative | Journal of neurochemistry (2025)
A hallmark of Alzheimer disease (AD) and tauopathies, severe neurodegenerative diseases, is the progressive aggregation of Tau, also known as microtubule-associated Tau protein. Full-length Tau
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Altered metabolic function induced by Aβ-oligomers and PSEN1 mutations in iPSC-derived astrocytes.
Cell type: iPSC | Technique: general | Disease/area: Alzheimer disease, neurodegenerative | Journal of neurochemistry (2025)
Altered energy metabolism in Alzheimer's disease (AD) is a major pathological hallmark implicated in the early stages of the disease process. Astrocytes play a central role in brain homeostasis and are implicated in multiple neurodegenerative diseases. Al
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Locus coeruleus vulnerability to tau hyperphosphorylation in a rat model.
Cell type: neuron | Technique: general | Disease/area: Alzheimer disease | Aging cell (2025)
Post-mortem investigations indicate that the locus coeruleus (LC) is the initial site of hyperphosphorylated pretangle tau, a precursor to neurofibrillary tangles (NFTs) found in Alzheimer's disease (AD). The presence of pretangle tau and NFTs correlates
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Increased levels of extracellular matrix proteins associated with extracellular vesicles from brains of aged mice.
Cell type: general | Technique: EdU proliferation | Disease/area: Alzheimer disease, inflammation | Aging cell (2025)
Extracellular vesicles (EVs) are secreted by all major cell types of the brain, providing a mode of intercellular communication and a pathway for disposal of cellular debris. EVs help maintain healthy brain function, but may also contribute to diseases affecti
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Evolving alterations of structural organization and functional connectivity in feedforward neural networks after induced P301L tau mutation.
Cell type: neuron | Technique: general | Disease/area: Alzheimer disease, neurodegenerative | The European journal of neuroscience (2024)
Reciprocal structure-function relationships underlie both healthy and pathological behaviours in complex neural networks. Thus, understanding neuropathology and network dysfunction requires a thorough investigation of the complex interactions between structura
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Bioreactor-produced iPSCs-derived dopaminergic neuron-containing neural microtissues innervate and normalize rotational bias in a dose-dependent manner in a Parkinson rat model.
Cell type: T cell, iPSC, neuron | Technique: flow cytometry, qPCR | Disease/area: Parkinson disease | Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2024)
A breadth of preclinical studies now support the rationale of pluripotent stem cell-derived cell replacement therapies to alleviate motor symptoms in Parkinsonian patients. Replacement of the primary dysfunctional cell population in the disease, i.e. the A9 do
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Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab.
Cell type: general | Technique: general | Disease/area: Alzheimer disease | Life science alliance (2024)
The amyloid β peptide (Aβ), starting with pyroglutamate (pE) at position 3 and ending at position 42 (Aβ3pE-42), predominantly accumulates in the brains of Alzheimer's disease. Consistently, donanemab, a therapeutic antibody raised against Aβ3pE-42, has b
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Effects of Amyloid Beta (Aβ) Oligomers on Blood-Brain Barrier Using a 3D Microfluidic Vasculature-on-a-Chip Model.
Cell type: endothelial | Technique: general | Disease/area: Alzheimer disease | Applied sciences (Basel, Switzerland) (2024)
The disruption of the blood-brain barrier (BBB) in Alzheimer's Disease (AD) is largely influenced by amyloid beta (Aβ). In this study, we developed a high-throughput microfluidic BBB model devoid of a physical membrane, featuring endothelial cells interac
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iPSC-derived hindbrain organoids to evaluate escitalopram oxalate treatment responses targeting neuropsychiatric symptoms in Alzheimer's disease.
Cell type: iPSC, neuron | Technique: flow cytometry, immunocytochemistry | Disease/area: Alzheimer disease | Molecular psychiatry (2024)
Alzheimer's disease (AD) is the most common cause of dementia, and the gradual deterioration of brain function eventually leads to death. Almost all AD patients suffer from neuropsychiatric symptoms (NPS), the emergence of which correlates with dysfunctio
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Intrathecal gastrodin alleviates allodynia in a rat spinal nerve ligation model through NLRP3 inflammasome inhibition.
Cell type: neuron | Technique: general | Disease/area: Alzheimer disease, inflammation | BMC complementary medicine and therapies (2024)
Gastrodin (GAS), a main bioactive component of the herbal plant, Gastrodia elata Blume, has shown to have beneficial effects on neuroinflammatory diseases such as Alzheimer's disease in animal studies and migraine in clinical studies. Inflammasome is a mu
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Adolescent stress accelerates postpartum novelty recognition impairment in 5xFAD mice.
Cell type: general | Technique: general | Disease/area: Alzheimer disease | Frontiers in neuroscience (2024)
Pregnancy and the postpartum period induce physiological changes that can influence women's cognitive functions. Alzheimer's disease (AD) has a higher prevalence in women and is exacerbated by early life stress. In the present study, we found that la
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Prolonged depletion of profilin 1 or F-actin causes an adaptive response in microtubules.
Cell type: neuron | Technique: EdU proliferation | Disease/area: neurodegenerative | The Journal of cell biology (2024)
In addition to its well-established role in actin assembly, profilin 1 (PFN1) has been shown to bind to tubulin and alter microtubule growth. However, whether PFN1's predominant control over microtubules in cells occurs through direct regulation of tubuli
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Detection of pTDP-43 via routine muscle biopsy: A promising diagnostic biomarker for amyotrophic lateral sclerosis.
Cell type: neuron | Technique: EdU proliferation | Disease/area: neurodegenerative | Brain pathology (Zurich, Switzerland) (2024)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, pathologically characterized by TDP-43 aggregates. Recent evidence has been indicated that phosphorylated TDP-43 (pTDP-43) is present not only in motor neurons but also in muscle t
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An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders.
Cell type: iPSC, macrophage, microglia | Technique: EdU proliferation | Disease/area: Parkinson disease, inflammation, neurodegenerative | Molecular neurodegeneration (2024)
Induced pluripotent stem cell-derived microglia (iMGL) represent an excellent tool in studying microglial function in health and disease. Yet, since differentiation and survival of iMGL are highly reliant on colony-stimulating factor 1 receptor (CSF1R) signali
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Hippocampal hyperphosphorylated tau-induced deficiency is rescued by L-type calcium channel blockade.
Cell type: neuron | Technique: general | Disease/area: Alzheimer disease | Brain communications (2024)
Aging and Alzheimer's disease are associated with chronic elevations in neuronal calcium influx
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5-HT
Cell type: endothelial | Technique: general | Disease/area: neurodegenerative | Frontiers in cellular neuroscience (2024)
Vascular and mitochondrial dysfunction are well-established consequences of multiple central nervous system (CNS) disorders, including neurodegenerative diseases and traumatic injuries. We previously reported that 5-hydroxytryptamine 1F receptor (5-HT Lasmidit
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Small-molecule compound from AlphaScreen disrupts tau-glycan interface.
Cell type: neuron | Technique: general | Disease/area: neurodegenerative | Frontiers in molecular biosciences (2022)
Tauopathies are neurodegenerative diseases characterized by intracellular abnormal tau deposits in the brain. Tau aggregates can propagate from one neuron to another in a prion-like manner, mediated by the interaction between tau and cell surface heparan sulfa
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