Curated literature review of independent peer-reviewed studies that used the EVOS M5000 Imaging System. Each paper is summarised by cell type, imaging technique, and disease area, with links to Google Scholar, PubMed, PMC and DOI where available. Plankton & Zoom does not host paywalled content.
Skin biology, fibroblast behaviour, and regenerative cell models are common use-cases for the EVOS M5000, from aged dermal fibroblast cultures to atopic dermatitis, intestinal fibrosis, implant-stoma responses, and lung progenitor cell separation. The studies below are independent of the manufacturer’s citation list. These papers were identified by searching the open-access literature and verifying that the full text explicitly mentions the EVOS M5000 Imaging System as a microscope; they are not part of the manufacturer’s curated citation list.
Cell type: Skin cells / keratinocytes / fibroblasts
Imaging technique: Brightfield/phase-contrast optical microscopy
Disease area: Atopic dermatitis / skin inflammation
Mediators Inflamm PMC13347627
Cell type: Aged dermal fibroblasts (mouse primary)
Imaging technique: Live-cell / brightfield imaging
Disease area: Aging / impaired wound healing
Aged dermal fibroblasts exhibit reduced migration, proliferation, and extracellular matrix (ECM) production, alongside upregulation of pro-inflammatory signaling that disrupts the proliferative, granulation, and remodeling phases of wound healing. Despite these age-related impairments, tissue engineering biomaterials a...
Cells Tissues Organs PMID 42319880 — PMC13317481
Google Scholar | PubMed | PMC | DOI
Cell type: Intestinal fibroblasts (human gut-on-a-chip)
Imaging technique: Microengineered 3D gut-on-chip imaging
Disease area: Intestinal fibrosis / Crohn-like remodeling
Biomechanical cues such as fluid shear stress and mechanical strain regulate intestinal physiology, yet their roles in shaping fibroblast fate during early fibrotic remodeling remain poorly defined. Here, we use a microengineered human gut-on-a-chip model that enables independent control of shear stress and mechanical ...
Adv Sci (Weinh) PMID 41961487 — PMC13317784
Google Scholar | PubMed | PMC | DOI
Cell type: Human skin explants / keratinocytes
Imaging technique: Ex vivo histology / fluorescence imaging
Disease area: Atopic dermatitis / S. aureus skin dysbiosis
Maintaining a balanced skin microbiota is essential for preserving epidermal barrier integrity and overall skin health. Dysbiosis, particularly the opportunistic overgrowth of Staphylococcus aureus, is associated with barrier dysfunction and inflammatory dermatoses such as atopic dermatitis, psoriasis, and acne. In dys...
Microorganisms PMID 42354869 — PMC13304451
Google Scholar | PubMed | PMC | DOI
Cell type: Human P63+ lung progenitor cells
Imaging technique: Inertial microfluidics + fluorescence/brightfield imaging
Disease area: Lung regeneration / repair
Recent clinical trials have highlighted the potential of P63+ lung progenitor cell (LPC) transplantation for lung repair and regeneration. Currently, ex vivo P63+ LPC expansion depends on coculture with growth-arrested fibroblast feeder cells (GAFs), necessitating repeated purification during passaging. While different...
Anal Chem PMID 42126293 — PMC13218359
Google Scholar | PubMed | PMC | DOI
Cell type: Human fibroblasts
Imaging technique: Brightfield/fluorescence imaging
Disease area: Implant / stoma / fibroblast response
A soft-anchored titanium (Ti-6Al-4V) mesh implantable device was designed and morphologically characterised in an in vitro study. The mesh implant consists of a titanium mesh aimed at preserving continence and improving the quality of life for patients with a stoma. Titanium alloys are widely used in implantable device...
Sci Rep PMID 42230665 — PMC13230510
Google Scholar | PubMed | PMC | DOI
Cell type: Placenta-derived mesenchymal stem cells / ovarian cells
Imaging technique: Histology / fluorescence imaging
Disease area: Ovarian dysfunction / toxic injury
Ovarian dysfunction resulting from metabolic or toxic injury is characterized by follicular depletion, stromal remodeling, oxidative stress, and endocrine dysregulation. Placenta-derived mesenchymal stem cells (PD-MSCs) have been proposed as a potential therapeutic approach due to their paracrine factors, including pla...
Antioxidants (Basel) PMID 42193225 — PMC13203319
Google Scholar | PubMed | PMC | DOI