EVOS M5000 in Tissue & Disease Model Research — Wave 3 Part 2
Independent studies using the EVOS M5000 Imaging System for cardiovascular, bone, skin, fibrosis and metabolic disease models. Each entry was discovered independently of Thermo Fisher's curated EVOS M5000 citations and verified to mention the EVOS M5000 Imaging System as a microscope in the full text. Paper cards link to Google Scholar, PubMed, PMC and DOI when available.
EVOS M5000IndependentWave 3
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Proteomic analysis reveals activation of platelet- and fibrosis-related pathways in hearts of ApoE
Cell type: general | Technique: knockout | Disease/area: cardiovascular, fibrosis | Scientific reports (2023)
Air pollution is an environmental risk factor linked to multiple human diseases including cardiovascular diseases (CVDs). While particulate matter (PM) emitted by diesel exhaust damages multiple organ systems, heart disease is one of the most severe pathologie
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Fenofibrate reduces glucose-induced barrier dysfunction in feline enteroids.
Cell type: epithelial | Technique: EdU proliferation | Disease/area: diabetes | Scientific reports (2023)
Diabetes mellitus (DM) is a common chronic metabolic disease in humans and household cats that is characterized by persistent hyperglycemia. DM is associated with dysfunction of the intestinal barrier. This barrier is comprised of an epithelial monolayer that
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(Title unavailable)
Cell type: endothelial | Technique: general | Disease/area: obesity | Aging (2023)
(Abstract unavailable)
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Retention of Key Characteristics of Unprocessed Chorion Tissue Resulting in a Robust Scaffold to Support Wound Healing.
Cell type: fibroblast | Technique: wound healing | Disease/area: wound healing | International journal of molecular sciences (2023)
Placental membranes have been widely studied and used clinically for wound care applications, but there is limited published information on the benefits of using the chorion membrane. The chorion membrane represents a promising source of placental-derived tiss
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Antler stem cell exosomes alleviate pulmonary fibrosis via inhibiting recruitment of monocyte macrophage, rather than polarization of M2 macrophages in mice.
Cell type: fibroblast, macrophage | Technique: EdU proliferation | Disease/area: fibrosis | Cell death discovery (2023)
Pulmonary fibrosis (PF), a chronic interstitial lung disease, is characterized by over-abundant deposition of extracellular matrix consisting mainly of collagen I. In previous studies, we demonstrated that deer antler stem cells (AnSCs), a novel type of adult
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Evaluation of polyetheretherketone composites modified by calcium silicate and carbon nanotubes for bone regeneration: mechanical properties, biomineralization and induction of osteoblasts.
Cell type: osteoblast | Technique: general | Disease/area: bone disease | Frontiers in bioengineering and biotechnology (2023)
Desired orthopedic implant materials must have a good biological activity and possess appropriate mechanical property that correspond to those of human bone. Although polyetheretherketone (PEEK) has displayed a promising application prospect in musculoskeletal
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Combined Treatment of
Cell type: adipocyte | Technique: general | Disease/area: obesity | Nutrients (2023)
Mori Folium (
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Megakaryocyte NLRP3 hyperactivation induces mild anemia and potentiates inflammatory response in mice.
Cell type: general | Technique: EdU proliferation | Disease/area: cardiovascular, inflammation | Frontiers in immunology (2023)
The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome has been described in both immune cells and platelets, but its role in the megakaryocyte (MK) lineage remains elusive. The aim of this study was to explore the role of NLRP3 inflammasom
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Ixeris dentata and Lactobacillus gasseri media protect against periodontitis through Nrf2-HO-1 signalling pathway.
Cell type: general | Technique: EdU proliferation | Disease/area: bone disease, inflammation | Scientific reports (2023)
Periodontitis is an infectious inflammation in the gums characterized by loss of periodontal ligaments and alveolar bone. Its persistent inflammation could result in tooth loss and other health issues. Ixeris dentata (IXD) and Lactobacillus gasseri media (LGM)
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Squid leucophore-inspired engineering of optically dynamic human cells.
Cell type: general | Technique: general | Disease/area: skin disease | iScience (2023)
Cephalopods (e.g., squids, octopuses, and cuttlefishes) possess remarkable dynamic camouflage abilities and therefore have emerged as powerful sources of inspiration for the engineering of dynamic optical technologies. Within this context, we have focused on t
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Black Wheat Extracts (Arriheuk) Regulate Adipogenesis and Lipolysis via Adenosine Monophosphate (AMP) Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Signaling Pathways.
Cell type: adipocyte | Technique: EdU proliferation | Disease/area: obesity | Foods (Basel, Switzerland) (2023)
Polyphenols and other compounds with antioxidant properties are found in plants and are one of the main antioxidants proven to reduce body weight and the risk of insulin resistance. Still, the mechanism behind the protective effects against obesity remains unc
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Clodronate Liposome-Mediated Phagocytic Hemocyte Depletion Affects the Regeneration of the Cephalic Tentacle of the Invasive Snail,
Cell type: general | Technique: general | Disease/area: wound healing | Biology (2023)
After amputation, granular hemocytes infiltrate the blastema of regenerating cephalic tentacles of the freshwater snail
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Wound Dressings Based on Sodium Alginate-Polyvinyl Alcohol-
Cell type: general | Technique: general | Disease/area: wound healing | Pharmaceutics (2023)
Biopolymers have significant pharmaceutical applications, and their blending has favorable characteristics for their pharmaceutical properties compared to the sole components. In this work, sodium alginate (SA) as a marine biopolymer was blended with poly(viny
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A refined protocol for the isolation and monoculture of primary mouse renal peritubular endothelial cells.
Cell type: endothelial, epithelial | Technique: EdU proliferation | Disease/area: cardiovascular | Frontiers in cardiovascular medicine (2023)
During an episode of acute kidney injury (AKI), a sudden and rapid decline in renal function is often accompanied by a persistent reduction in mitochondrial function, microvasculature dysfunction/rarefaction, and tubular epithelial injury/necrosis. Additionall
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Targeting SDF-1 as an efficient strategy to resolve skin hyperpigmentation issues with Himanthalia elongata extract.
Cell type: fibroblast | Technique: EdU proliferation | Disease/area: skin disease | Journal of cosmetic dermatology (2023)
During aging, human skin is facing hyperpigmentation disorders: senile lentigo (chronobiologic aging) leads to loss of melanogenesis' control while solar lentigo (UV exposure) promotes an increase of oxidized proteins, melanogenesis, and lipofuscin. Strom
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Ablation of Shank3 alleviates cardiac dysfunction in aging mice by promoting CaMKII activation and Parkin-mediated mitophagy.
Cell type: general | Technique: knockout | Disease/area: cardiovascular, neurodegenerative | Redox biology (2022)
Compromised mitophagy and mitochondrial homeostasis are major contributors for the etiology of cardiac aging, although the precise underlying mechanisms remains elusive. Shank3, a heart-enriched protein, has recently been reported to regulate aging-related neu
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Curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning.
Cell type: general | Technique: general | Disease/area: bone disease, diabetes | Cell reports (2022)
Mixed hematopoietic chimerism can promote immune tolerance of donor-matched transplanted tissues, like pancreatic islets. However, adoption of this strategy is limited by the toxicity of standard treatments that enable donor hematopoietic cell engraftment. Her
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Quantitative increase in T regulatory cells enhances bone remodeling in
Cell type: osteoblast | Technique: EdU proliferation | Disease/area: bone disease, inflammation | iScience (2022)
Osteogenesis imperfecta (OI) is characterized by repeated bone fractures. Recent studies have shown that T lymphocytes and regulatory T cells (Tregs) regulate the functions of osteoclasts and osteoblasts, thus playing a role in bone turnover. We demonstrate an
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Modelling Metabolic Shifts during Cardiomyocyte Differentiation, Iron Deficiency and Transferrin Rescue Using Human Pluripotent Stem Cells.
Cell type: cardiomyocyte, iPSC | Technique: general | Disease/area: cardiovascular | Metabolites (2021)
Cardiomyocytes rely on specialised metabolism to meet the high energy demand of the heart. During heart development, metabolism matures and shifts from the predominant utilisation of glycolysis and glutamine oxidation towards lactate and fatty acid oxidation.
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Reduced receptor for advanced glycation end products is associated with α-SMA expression in patients with idiopathic pulmonary fibrosis and mice.
Cell type: epithelial, macrophage | Technique: EdU proliferation, immunohistochemistry, western blot | Disease/area: cardiovascular, fibrosis, inflammation | Laboratory animal research (2021)
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease. Despite alveolar epithelial cells is crucial role in lung, its contribution and the associated biomarker remain unknown in the pathogenesis of IPF. Recently, environmen
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Diminishment of Nrf2 Antioxidative Defense Aggravates Nephrotoxicity of Melamine and Oxalate Coexposure.
Cell type: general | Technique: EdU proliferation | Disease/area: fibrosis | Antioxidants (Basel, Switzerland) (2021)
Chronic kidney disease (CKD) usually causes devastating healthy impacts on patients. However, the causes affecting the decline of kidney function are not fully revealed, especially the involvement of environmental pollutants. We have revealed that exposure to
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Human Amniotic Fluid Stem Cell-Derived Exosomes as a Novel Cell-Free Therapy for Cutaneous Regeneration.
Cell type: fibroblast | Technique: EdU proliferation, wound healing | Disease/area: skin disease, wound healing | Frontiers in cell and developmental biology (2021)
Adult wound healing often results in fibrotic scarring that is caused by myofibroblast aggregation. Human amniotic fluid stem cells (hAFSCs) exhibit significantly anti-fibrotic scarring properties during wound healing. However, it is little known whether hAFSC
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Exosomes Derived from Fisetin-Treated Keratinocytes Mediate Hair Growth Promotion.
Cell type: T cell, keratinocyte | Technique: general | Disease/area: skin disease | Nutrients (2021)
Enhanced telomerase reverse transcriptase (TERT) levels in dermal keratinocytes can serve as a novel target for hair growth promotion. Previously, we identified fisetin using a system for screening food components that can activate the TERT promoter in HaCaT c
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Caveolin-1 mediates soft scaffold-enhanced adipogenesis of human mesenchymal stem cells.
Cell type: MSC, T cell, adipocyte | Technique: EdU proliferation | Disease/area: bone disease | Stem cell research & therapy (2021)
Human bone marrow-derived mesenchymal stem cells (hBMSCs) can differentiate into adipocytes upon stimulation and are considered an appropriate cell source for adipose tissue engineering. In addition to biochemical cues, the stiffness of a substrate that cells
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Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes.
Cell type: general | Technique: EdU proliferation, knockout | Disease/area: arthritis, cardiovascular | Free radical biology & medicine (2021)
The nuclear localized protein deacetylase, SIRT6, has been identified as a crucial regulator of biological processes that drive aging. Among these processes, SIRT6 can promote resistance to oxidative stress conditions, but the precise mechanisms remain unclear
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