Disease Model Microscope UK: EVOS M5000 Tissue Wave 3
Peer-reviewed studies discovered independently of Thermo Fisher's curated EVOS M5000 citations. Each paper was full-text verified to mention the EVOS M5000 Imaging System as a microscope. Cards link to Google Scholar, PubMed, PMC and DOI.
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Diminishment of Nrf2 Antioxidative Defense Aggravates Nephrotoxicity of Melamine and Oxalate Coexposure.
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Chronic kidney disease (CKD) usually causes devastating healthy impacts on patients. However, the causes affecting the decline of kidney function are not fully revealed, especially the involvement of environmental pollutants. We have revealed that exposure to melamine, a ubiquitous chemical in daily life, is linked to adverse kidney outcomes. Hyperoxaluria that results from exp
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Alternative splicing of NF-YA promotes prostate cancer aggressiveness and represents a new molecular marker for clinical stratification of patients.
Cell type: Cancer cell | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Approaches based on expression signatures of prostate cancer (PCa) have been proposed to predict patient outcomes and response to treatments. The transcription factor NF-Y participates to the progression from benign epithelium to both localized and metastatic PCa and is associated with aggressive transcriptional profile. The gene encoding for NF-YA, the DNA-binding subunit of N
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Extracellular Vesicles Mediate the Intercellular Exchange of Nanoparticles.
Cell type: T cell | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
To exert their therapeutic effects, nanoparticles (NPs) often need to travel into the tissues composed of multilayered cells. Accumulative evidence has revealed the crucial role of transcellular transport route (entry into one cell, exocytosis, and re-entry into another) in this process. While NP endocytosis and subcellular transport are intensively characterized, the exocytosi
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Bioluminescence Sensing in 3D Spherical Microtissues for Multiple Bioactivity Analysis of Environmental Samples.
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
The development of predictive
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Effects of lifelong spontaneous exercise on skeletal muscle and angiogenesis in super-aged mice.
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
There has been an increasing awareness of sarcopenia, which is characterized by a concomitant decrease in skeletal muscle mass and quality due to aging. Resistance exercise is considered more effective than aerobic exercise in terms of therapeutic exercise. To confirm the effect of long-term aerobic exercise in preventing sarcopenia, we evaluated the skeletal muscle mass, quali
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MAX: a simple, affordable, and rapid tissue clearing reagent for 3D imaging of wide variety of biological specimens.
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Transparency of biological specimens is crucial to obtaining detailed 3-dimensional images and understanding the structure and function of biological specimens. This transparency or tissue clearing can be achieved by adjusting the refractive index (RI) with embedding media and removing light barriers such as lipids, inorganic deposits, and pigments. Many currently available pro
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Tumor necrosis factor alpha and palmitate simulate bovine fatty liver disease in vitro when using abattoir-derived primary bovine hepatocytes isolated by a novel nonperfusion method.
Cell type: Hepatocyte | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Hepatic lipidosis (i.e., fatty liver) is a common periparturient disease in high-producing dairy cattle affecting nearly 50% of cows to some degree and costing an estimated 60 million dollars annually. Large animal studies are costly, labor intensive, and are not well suited to mechanistic studies. Traditionally, mechanistic studies employ in vitro methodologies, utilizing esta
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Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats.
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Pancreatic islet transplantation efficacy for type 1 diabetes (T1D) management is limited by hypoxia-related graft attrition and need for systemic immunosuppression. To overcome these challenges, we developed the Neovascularized Implantable Cell Homing and Encapsulation (NICHE) device, which integrates direct vascularization for facile mass transfer and localized immunosuppress
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CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression.
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Coenzyme Q (CoQ, aka ubiquinone) is a key component of the mitochondrial electron transport chain (ETC) and membrane-incorporated antioxidant. CoQ10 deficiencies encompass a heterogeneous spectrum of clinical phenotypes and can be caused by hereditary mutations in the biosynthesis pathway or result from pharmacological interventions such as HMG-CoA Reductase inhibitors, and sta
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Delayed renal injury in survivors of hematologic acute radiation syndrome.
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
A mass casualty disaster involving radiological or nuclear agents continues to be a public health concern which requires consideration of both acute and late tissue toxicities in exposed victims. With the advent of advanced treatment options for the mitigation of hematological injuries, there are likely to be survivors of total body irradiation (TBI) exposures as high as 8-10 G
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From Free-Radical to Radical-Free: A Paradigm Shift in Light-Mediated Biofabrication.
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
In recent years, the development of novel photocrosslinking strategies and photoactivatable materials has stimulated widespread use of light-mediated biofabrication techniques. However, despite great progress toward more efficient and biocompatible photochemical strategies, current photoresins still rely on photoinitiators (PIs) producing radical-initiating species to trigger t
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Whole-mount staining of mouse colorectal cancer organoids and fibroblast-organoid co-cultures.
Cell type: Fibroblast | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Imaging organoid culture provides an excellent tool for studying complex diseases such as cancer. However, retaining the morphology of intact organoids for immunolabeling has been challenging. Here, we describe a protocol for immunofluorescence staining in intact colorectal cancer organoids derived from mice. We also describe additional steps for co-culture with mouse fibroblas
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HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44
Cell type: Epithelial | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Ulcerative colitis (UC) is characterized by severe inflammation and destruction of the intestinal epithelium, and is associated with specific risk single nucleotide polymorphisms in HLA class II. Given the recently discovered interactions between subsets of HLA-DP molecules and the activating natural killer (NK) cell receptor NKp44, genetic associations of UC and HLA-DP haploty
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Adverse effects of ovarian cryopreservation and auto-transplantation on ovarian grafts and quality of produced oocytes in a mouse model.
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
The process of ovarian cryopreservation and transplantation is the only feasible fertility preservation method for prepubertal girls and female patients with cancer who cannot delay radiotherapy and chemotherapy. However, basic research on this technique is lacking. To better understand ovarian function and oocyte quality after ovarian tissue (OT) transplantation, we characteri
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Exogenous recombinant N-acetylgalactosamine-4-sulfatase (Arylsulfatase B; ARSB) inhibits progression of B16F10 cutaneous melanomas and modulates cell signaling.
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
In the syngeneic, subcutaneous B16F10 mouse model of malignant melanoma, treatment with exogenous ARSB markedly reduced tumor size and extended survival. In vivo experiments showed that local treatment with exogenous N-acetylgalactosamine-4-sulfatase (Arylsulfatase B; ARSB) led to reduced tumor growth over time (p < 0.0001) and improved the probability of survival up to 21 days
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Fenofibrate reduces glucose-induced barrier dysfunction in feline enteroids.
Cell type: Epithelial | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Diabetes mellitus (DM) is a common chronic metabolic disease in humans and household cats that is characterized by persistent hyperglycemia. DM is associated with dysfunction of the intestinal barrier. This barrier is comprised of an epithelial monolayer that contains a network of tight junctions that adjoin cells and regulate paracellular movement of water and solutes. The mec
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Retinoic acid signaling regulates spatiotemporal specification of human green and red cones.
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Trichromacy is unique to primates among placental mammals, enabled by blue (short/S), green (medium/M), and red (long/L) cones. In humans, great apes, and Old World monkeys, cones make a poorly understood choice between M and L cone subtype fates. To determine mechanisms specifying M and L cones, we developed an approach to visualize expression of the highly similar M- and L-op
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mTert induction in p21-positive cells counteracts capillary rarefaction and pulmonary emphysema.
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Lung diseases develop when telomeres shorten beyond a critical point. We constructed a mouse model in which the catalytic subunit of telomerase (mTert), or its catalytically inactive form (mTert
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Chitosan modified with PAP as a promising delivery system for melatonin in the treatment of osteoporosis: targeting the divalent metal transporter 1.
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
The demands for novel and efficient therapies have gradually increased with the rising concerns of osteoporosis (OP). The most popular method in promoting bone regeneration during osteoporotic conditions consists of loading bioactive materials with different drugs to treat osteoporotic bones by either promoting the process of osteogenesis, or by inhibiting the activity of osteo
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Assessment of Ingested Micro- and Nanoplastic (MNP)-Mediated Genotoxicity in an In Vitro Model of the Small Intestinal Epithelium (SIE).
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Micro- and nanoplastics (MNPs) have become ubiquitous contaminants of water and foods, resulting in high levels of human ingestion exposure. MNPs have been found in human blood and multiple tissues, suggesting that they are readily absorbed by the gastrointestinal tract (GIT) and widely distributed. Growing toxicological evidence suggests that ingested MNPs may pose a serious h
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Combinatorial macrophage induced innate immunotherapy against Ewing sarcoma: Turning "Two Keys" simultaneously.
Cell type: Macrophage | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Macrophages play important roles in phagocytosing tumor cells. However, tumors escape macrophage phagocytosis in part through the expression of anti-phagocytic signals, most commonly CD47. In Ewing sarcoma (ES), we found that tumor cells utilize dual mechanisms to evade macrophage clearance by simultaneously over-expressing CD47 and down-regulating cell surface calreticulin (cs
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Harnessing Decellularized Extracellular Matrix for Enhanced Fidelity in Colorectal Cancer Organoid and Cell-Derived Xenograft Models.
Cell type: Cancer cell | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
This study evaluates the efficacy of a decellularized intestine tissue-derived extracellular matrix (Intestine ECM) as a scaffold for culturing colorectal cancer (CRC) organoids and establishing cell-derived xenograft (CDX) models, comparing its performance to traditional Matrigel. Intestine ECM demonstrates comparable support for organoid formation and cellular function, highl
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Spatiotemporal single-cell RNA sequencing reveals the role of steroid hormone pathway during chicken primordial follicle formation.
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
The size of the initial primordial follicle pool in the ovary depends on primordial follicle formation, which determines the female reproductive lifespan. However, the molecular regulation of primordial follicle formation in chickens remains unclear. In this study, the left ovaries of chickens were collected at 2 d posthatch (dph), 5.5 dph, and 10.5 dph to examine the formation
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Short-term therapy with R568 ameliorated secondary hyperparathyroidism but does not prevent aortic valve calcification in uremic rats.
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Renal failure associated aortic valve calcification (AVC) is the result of hyperphosphatemia and hyperparathyroidism. Calcimimetics is an effective tool for management of secondary hyperparathyroidism. Our goal was to evaluate the effect of the medical intervention with calcimimetic R568 on the AVC process. The experimental design consisted of administering a uremia-inducing ph
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Search for putative gene regulatory motifs in CAHS3, linked to anhydrobiosis in a tardigrade Ramazzottius varieornatus, in vivo and in silico.
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Tardigrades possess the ability to enter an almost completely dehydrated state, anhydrobiosis. The CAHS (cytosolic abundant heat-soluble) protein family has been identified as one of the anhydrobiosis-related proteins. In particular, CAHS3 protein from an anhydrobiotic tardigrade, Ramazzottius varieornatus, shows heat-solubility and reversible condensation and is one of the mos
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Comparative Analysis of Commercial and Home-Made Media on RSPO1/S6R Axis in Organoids with Different Wnt Backgrounds: A Methodological Guide for the Selection of Intestinal Patient-Derived Organoids Culture Media.
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
WNT3A is an intestinal ligand triggering the Wnt/β-catenin (Wnt) pathway, which can be enhanced by R-spondin 1 (RSPO1) through the RSPO1-LGR axis or antagonized by the adenomatous polyposis coli (APC) protein supporting β-catenin-degradation. Wnt interplays with several pathways including PI3K/mTOR (mTOR). In this study, we evaluated the influence of WNT3A-commercial and home-m
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Comparative evaluation of the modulatory role of 1,25-dihydroxy-vitamin D
Cell type: Epithelial | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
The use of conventional two-dimensional (2D) culture of the porcine intestinal epithelial cell (IEC) line IPEC-J2 in animal nutrition research has the disadvantage that IEC function is studied under unphysiological conditions, which limits the ability of transferring knowledge to the in vivo-situation. Thus, the aim of the present study was to establish a more convincing and me
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Enhancement of renal fibrosis in PHF20 transgenic mice.
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Plant homeodomain finger protein 20 (PHF20) plays a crucial role in various biological processes, but its involvement in renal fibrosis remains unclear. This study investigated the role of PHF20 in renal fibrosis using a unilateral ureteral obstruction (UUO) mouse model, a widely accepted model for chronic kidney disease. PHF20 transgenic (PHF20-TG) and wild-type (WT) mice were
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Late gestation maternal overnutrition alters gene expression and histomorphology in neonatal foal testes.
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Reproductive health of male offspring following perturbations in maternal nutrition is not well-described in the horse; therefore, the objective of this study was to determine the effects of maternal overnutrition on neonatal foal testicular development. Sixteen Quarter Horse mares were used in a completely randomized design and stratified by expected foaling date, body weight,
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Functional Analysis of HSD17B3-Deficient Male Mice Reveals Roles for HSD17B7 and HSD17B12 in Testosterone Biosynthesis.
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Historically, 17β-hydroxysteroid dehydrogenase type 3 (HSD17B3) was thought to be the key enzyme responsible for testicular testosterone production. In humans, loss-of-function mutations in HSD17B3 impair testosterone production during prenatal life leading to impaired development of androgen-dependent tissues in 46,XY individuals. However, male mice with HSD17B3 deficiency exh
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Flow Cytometric Analysis and Sorting of Murine Enteric Nervous System Cells: An Optimized Protocol.
Cell type: Neuron | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Isolation of neurons and glia from the enteric nervous system (ENS) enables ex vivo studies, including the analysis of genomic and transcriptomic profiles. While we previously reported a fluorescence-activated cell sorting (FACS)-based isolation protocol for human ENS cells, no equivalent exists for mice. As directly applying the human protocol to mouse tissue resulted in low r
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Sex hormone-binding globulin controls sex-specific lipolytic activity in human abdominal subcutaneous adipocytes.
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Regulation of lipid metabolism is fundamental for metabolic health, and adipose tissue is a central component in this process. Adipose tissue differs considerably between women and men in terms of a higher subcutaneous capacity for storage, which is linked to metabolic health, in women. Sex hormone-binding globulin (SHBG) contributes to the regulation of circulating sex hormone
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Therapeutic potential of human mesenchymal stromal cell-derived mitochondria in a rat model of surgical digestive fistula.
Cell type: Epithelial | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Mitochondria are central to cellular energy metabolism and play a critical role in tissue regeneration. Mitochondrial dysfunction contributes to a range of degenerative conditions and impaired wound healing, driving increasing interest in mitochondrial transplantation as a novel therapeutic strategy. Gastrointestinal wound healing is particularly susceptible to failure, with co
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A novel miniTurbo knock-in mouse reveals a protein interaction network of USP46 in the brain.
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Uncovering protein interaction networks in vivo is essential for understanding physiological and pathological processes. Here, we report the generation of a novel knock-in mouse model expressing miniTurbo, a highly active biotin ligase, fused to the endogenous Usp46 gene. This model enables proximity-dependent biotin labeling (BioID) of USP46-associated proteins in the brain. I
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Cerebral Organoids with Integrated Endothelial Networks Emulate the Neurovascular Unit and Mitigate Core Necrosis.
Cell type: Endothelial | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Cerebral organoids (COs) are multicellular, self-organized, in vitro, 3D brain-like tissues used for developmental biology, disease modelling, and drug screening. However, their lack of vascularity renders them less physiologically accurate. Vascularization of COs remains challenging due to the different requirements between COs and vascular cells, limited vascular network pene
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The Microbial Bile Acid Metabolite 3-Oxo-LCA Inhibits Colorectal Cancer Progression.
Cell type: Epithelial | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Bile acids (BA) not only influence the gut microbiome composition but are also metabolized by gut bacteria to form various microbial BAs. Among these, 3-oxo-lithocholic acid (3-oxo-LCA) and isoallo-LCA have been reported to modulate host immunity, suppress intestinal pathogens, and provide antiaging benefits, suggesting that they could also affect intestinal epithelial cells an
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DNA-mediated UCP1 overexpression in adipose tissue: A promising anti-obesity gene therapy.
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Obesity has emerged as a global health challenge. Although GLP-1 receptor agonists are showing considerable promise in weight loss, their clinical utility is partly limited by gastrointestinal adverse reactions and non-fat weight loss side effects. UCP1-mediated adipose thermogenesis is a critical process for body temperature maintenance and weight management. However, the lack
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From Bench to Chairside: Collagen Scaffolds in Combination with Mesenchymal Stromal Cells for Gingival Augmentation.
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
<b>Background/Objectives:</b> Gingival tissue deficiencies present significant treatment challenges. We investigated three xenogeneic collagen scaffolds-Fibro-Gide, FibroMATRIX, and Mucoderm-with and without human gingival MSCs for soft tissue augmentation. <b>Methods:</b> The study assessed scaffold properties (mechanical properties and micro-CT structure), cytocompatibility,
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Cytoskeletal protein KRT14 governs cisplatin resistance by modulating eIF4H-dependent ACOX2 translation and lipid metabolism in bladder cancer.
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Cisplatin-based chemotherapy remains a mainstay for the treatment of bladder cancer (BLCA); however, its clinical efficacy is frequently compromised by the emergence of chemoresistance, which leads to poor patient outcomes. Although known mechanisms-such as alterations in drug efflux, DNA repair, and key signaling pathways-have been implicated, they fail to fully explain the cl
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Sbno2-mediated tissue-resident alveolar macrophages: a novel therapeutic axis for sepsis-induced acute lung injury.
Cell type: Macrophage | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Sepsis-induced acute lung injury (ALI) is a critical clinical condition characterized by severe inflammation and alveolar epithelial barrier disruption, with limited effective treatments. Our study investigates the role of Sbno2-expressing tissue-resident alveolar macrophages (TR-AMs) in promoting alveolar epithelial cell (AEC) regeneration and barrier function in sepsis-induce
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Activator protein-1 (AP-1) inhibition prevents endothelial to mesenchymal transition in diabetes-associated atherosclerosis: a translational study.
Cell type: Endothelial | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
Endothelial to mesenchymal transition (EndMT), the transformation of endothelial cells into a mesenchymal-like state, is regulated by various factors, including transcription factors such as activator protein 1 (AP-1). While recent studies have confirmed the role of EndMT in atherosclerosis, the involvement of AP-1 in EndMT, particularly in the context of human diabetes, remain
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SETDB1/ATF7IP regulate the precise genome engineering of HUSH-regulated genes.
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
The use of programmable nucleases has transformed genome editing and functional genomics. Clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) was developed such that targeted genomic lesions [usually DNA double-stranded breaks (DSBs)] could be introduced in vivo with ease and precision. In the presence of homology donors, these lesions facili
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Utilizing
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Tissue & Disease Models
<i>Caenorhabditis elegans</i> is a multi-organ nematode widely used in various research fields of life science. It is favored for its ease of handling, short life cycle with high reproductive capacity, low maintenance costs, availability of diverse mutants, and substantial genomic and proteomic similarity to mammals. Since research involving <i>C. elegans</i> typically does not
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