EVOS M5000 in Tissue & Disease Model Research — Wave 3
Independent studies using the EVOS M5000 Imaging System for cardiovascular, bone, skin, fibrosis and metabolic disease models. Each entry was discovered independently of Thermo Fisher's curated EVOS M5000 citations and verified to mention the EVOS M5000 Imaging System as a microscope in the full text. Paper cards link to Google Scholar, PubMed, PMC and DOI when available.
EVOS M5000IndependentWave 3
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Silk cryogel and electrospun scaffold characterization for bone-tendon interface applications.
Cell type: T cell | Technique: general | Disease/area: bone disease | Frontiers in bioengineering and biotechnology (2026)
Hard-to-soft tissue interfaces, such as bone-tendon or bone-ligament junctions, remain a challenge to treat. Low healing success rates stem from the complexities at the interface, creating an urgent need for better models to elucidate the properties that enabl
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A phosphorous-based dendrimer targets mitochondria and normalizes the keratinocyte proliferation/differentiation balance to improve psoriasis.
Cell type: keratinocyte | Technique: general | Disease/area: inflammation, skin disease | PloS one (2026)
Psoriasis vulgaris is a common chronic inflammatory skin disease associated with hyperproliferation and defective differentiation of keratinocytes. Despite new effective treatments using biologicals targeting key cytokines or their receptors, innovative therap
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Proteomic mapping of Rosa damascena nanovesicles reveals plastid mitochondrial metabolic convergence and antimicrobial peptides.
Cell type: general | Technique: general | Disease/area: inflammation, skin disease | Plant signaling & behavior (2026)
(Abstract unavailable)
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Identification and Functional Characterization of Cytoprotective Crocodile-Derived Peptides against Oxidatively Stressed Human Keratinocytes.
Cell type: keratinocyte | Technique: general | Disease/area: skin disease | ACS omega (2026)
Oxidative stress-induced cellular damage is a primary contributor to pathological conditions such as accelerated skin aging. Consequently, there is a strong demand for efficacious antioxidants. Herein, we investigate the cytoprotective properties of
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Precision-Cut Bladder Slices: A Novel Model for the Study of Bladder Fibrosis and Potential Anti-Fibrotic Agents.
Cell type: general | Technique: EdU proliferation, qPCR | Disease/area: bone disease, fibrosis | International journal of urology : official journal of the Japanese Urological Association (2026)
Precision-cut tissue slice culture is an innovative ex vivo approach for studying fibrosis pathogenesis. Here, we report for the first time the use of human precision-cut bladder slices (PCBS) to investigate fibrotic changes and evaluate anti-fibrotic compound
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Mosaic partial epidermal reprogramming remodels neighbors and niches to refine skin homeostasis and repair.
Cell type: T cell, epithelial | Technique: EdU proliferation, wound healing | Disease/area: skin disease, wound healing | Nature communications (2026)
Adult stem cells and their niches communicate intricately for tissue maintenance and regeneration. However, effectively coordinating these complex interactions is challenging. Here, we demonstrate that transient dedifferentiation of a fraction of epithelial st
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Autologous cell therapy with CD133+ bone marrow-derived stem cells for Asherman Syndrome: a phase 1/2 trial.
Cell type: general | Technique: general | Disease/area: bone disease | Nature communications (2026)
Autologous CD133+ bone marrow-derived stem cell (BMDSC) therapy has been designated as an Orphan Drug by the EMA and FDA for the treatment of Asherman Syndrome (AS). This phase 1/2, non-randomized, open-label, single-arm trial assessed the safety and efficacy
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Coenzyme-based elastomeric adhesive patch as iron ion capturer to regulate iron metabolism for diabetic oral ulcer repair.
Cell type: general | Technique: EdU proliferation | Disease/area: wound healing | Bioactive materials (2026)
Iron metabolism imbalance under high-glucose and nutrient-rich conditions is a key factor inhibiting the healing of diabetic oral ulcers. This study confirms the extensive iron accumulation and ferroptosis occurrence in diabetic oral ulcers. To address this, a
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Antagonistic Mechanisms of Probiotic Aliivibrio sp. Strain Vl2 Against Moritella viscosa: Evidence from Co-cultivation and Targeted Transcriptomic Analysis.
Cell type: cell line | Technique: EdU proliferation | Disease/area: skin disease | Probiotics and antimicrobial proteins (2026)
Winter ulcers, primarily caused by Moritella viscosa, represent a significant challenge for the Norwegian aquaculture industry. Effective control measures are hampered by the lack of effective vaccines and limited use of antibiotics, driven by the global effor
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Paradoxical Maturity-Onset Diabetes of the Young Arising From Loss-of-Function Mutations in ATP-Sensitive Potassium Channels.
Cell type: general | Technique: general | Disease/area: diabetes | Diabetes (2026)
Pancreatic β-cell ATP-sensitive K+ (KATP) channel closure underlies electrical excitability and insulin release, but loss or inhibition of KATP channels can lead to paradoxical crossover from hyperinsulinism plus hypoglycemia, to glucose intolerance or diabete
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Wound healing and photodynamic potential of
Cell type: T cell, keratinocyte | Technique: wound healing | Disease/area: inflammation, wound healing | Frontiers in pharmacology (2025)
Chronic and infected wounds represent a persistent global health burden. Medicinal plants offer a promising source of wound-healing agents due to their multitarget activities, long history of traditional use, and accessibility. We evaluated the effects of met
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Single-cell RNA-sequencing-guided reactive oxygen species-scavenging hydrogel design for regeneration of osteoporotic bone.
Cell type: MSC, osteoblast | Technique: general | Disease/area: bone disease, osteoporosis | Journal of Zhejiang University. Science. B (2025)
The pathological microenvironment of osteoporosis poses a substantial clinical challenge for bone defect regeneration. Through single-cell RNA-sequencing (scRNA-seq) analysis, we identified a reactive oxygen species (ROS)-overloading osteoblast subpopulation a
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Endoglin as a BMP9 co-receptor in vascular endothelial cells: prodomain displacement and TGFBRII recruitment.
Cell type: endothelial | Technique: EdU proliferation | Disease/area: bone disease, cardiovascular | Nature communications (2025)
Endoglin (ENG) is a single-pass transmembrane protein highly expressed in vascular endothelial cells (ECs), where it plays fundamental roles in EC functions. ENG is implicated in several cardiovascular disorders including hereditary haemorrhagic telangiectasia
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PCSK9 inhibition ameliorates microplastic-induced endothelial redox imbalance via SIRT6 modulation.
Cell type: HeLa, endothelial | Technique: EdU proliferation, RT-qPCR, qPCR | Disease/area: cardiovascular, inflammation | Cellular & molecular biology letters (2025)
Microplastics (MPs) have emerged as significant environmental pollutants, posing a threat to ecosystems and humans. The presence of MPs in atherosclerotic plaques, exacerbating cardiovascular risk, has been recently reported. However, the molecular mechanism u
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CRE-Ter enhances murine bone differentiation, improves muscle cell atrophy, and increases irisin expression.
Cell type: cell line, osteoblast | Technique: general | Disease/area: bone disease, inflammation, osteoporosis | PloS one (2025)
Ternary complex of curcuminoid-rich extract (CRE-Ter) is a developed water-soluble Curcuma longa extract containing 14% w/w curcuminoids, hydroxypropyl-β-cyclodextrin, and polyvinylpyrrolidone K30. This study aimed to investigate the biomolecular effects of CR
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Dynamic cholangiocyte responses in a murine model of reversible cholestasis: macrophage remodeling and NF-Y-mediated TGFβ1 expression.
Cell type: epithelial, macrophage | Technique: general | Disease/area: fibrosis | American journal of physiology. Gastrointestinal and liver physiology (2025)
During cholestasis, cholangiocytes become activated, promoting macrophage-associated periductal infiltration and fibrosis. The cholangiocyte-specific mechanisms responsible for these processes are unclear. To gain insight into the cholangiocyte signaling mecha
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Engineering Poly(L-Lactic Acid)/Hydroxyapatite Scaffolds via Melt-Electrowriting: Enhancement of Osteochondral Cell Response in Human Nasal Chondrocytes.
Cell type: T cell | Technique: general | Disease/area: bone disease | Polymers (2025)
Osteochondral repair remains challenging due to cartilage's limited self-healing capacity and the structural complexity of the osteochondral interface, particularly the hypertrophic layer anchoring cartilage to bone. We fabricated melt electrowritten (MEW
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VBIT-4 Rescues Mitochondrial Dysfunction and Reduces Skeletal Muscle Degeneration in a Severe Model of Duchenne Muscular Dystrophy.
Cell type: general | Technique: EdU proliferation | Disease/area: fibrosis | International journal of molecular sciences (2025)
Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder caused by mutations in the
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Gallic acid released by a layered double hydroxide-coated scaffold of hydroxyapatite and β-tricalcium phosphate inhibits the osteoclast formation
Cell type: macrophage, osteoblast | Technique: EdU proliferation | Disease/area: bone disease | Biomaterials and biosystems (2025)
Following dental extraction, alveolar bone loss, driven by the osteoclast (OC) bone-eroding cells, is a relevant concern in dental practice since it could compromise the possibility of installing dental implants. This study aimed to develop a drug delivery sys
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Cooling-Triggered Release of Celecoxib from Implantable Alginate-Soluplus Composite Devices.
Cell type: general | Technique: general | Disease/area: inflammation, wound healing | ACS biomaterials science & engineering (2025)
Currently, on-demand treatment of pain (both chronic and acute) is primarily achieved using opioids that are delivered systemically. Unfortunately, these drugs are highly addictive; over 5 people per hour die from opioid abuse in the US alone. A safer, nonsyst
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Nrf2/Nlrp3 signaling in aging BMSCs: Traf6 intervention as a novel approach to osteoporosis treatment.
Cell type: MSC | Technique: immunofluorescence, immunohistochemistry, transfection, western blot | Disease/area: bone disease, inflammation, osteoporosis | Redox biology (2025)
Senile osteoporosis progression is closely related to the decreased osteogenic differentiation capacity of senescent bone marrow stromal stem cells (BMSCs). This study demonstrated that the Traf6-mediated Nrf2/Nlrp3 signaling axis significantly influences infl
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Synergistic Combinations of Native Australian Plants For Skin Inflammation and Wound Healing.
Cell type: general | Technique: wound healing | Disease/area: inflammation, skin disease, wound healing | Biomedicines (2025)
(Abstract unavailable)
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Biomimetic, Suturable, and Extensible Electrospun Scaffolds for Lower Urinary Tract Surgical Reconstruction.
Cell type: fibroblast | Technique: EdU proliferation | Disease/area: fibrosis, inflammation, skin disease | Advanced healthcare materials (2025)
Common autologous tissue sources used for the repair or replacement of lower urinary tract (LUT) organs include the inner cheek (buccal), small and large bowels, and foreskin. These sources have limited availability, introduce the risk of donor site complicati
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Comparative analysis of periodontal ligament stem cell characteristics in type 2 diabetic and non-diabetic patients with periodontitis.
Cell type: T cell | Technique: MTT | Disease/area: diabetes | Journal of oral and maxillofacial pathology : JOMFP (2025)
Periodontitis, whether associated with diabetes or not, may have an impact on periodontal ligament stem cells (PDLSCs), which can adversely affect the regeneration of lost periodontal tissues and therefore treatment outcome. This study aimed to analyse the cha
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Matrix metalloproteinase-2 as a novel regulator of glucose utilization by adipocytes.
Cell type: adipocyte | Technique: general | Disease/area: obesity | Scientific reports (2025)
Glucose transporter 4 (GLUT4) expression on white adipocytes is critical for facilitating cellular uptake of blood glucose, failure of which promotes hyperglycemia. Matrix metalloproteinases (MMPs) play a crucial role in remodeling the white adipose tissue (WA
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Hypotaurine Reduces Glucose-Mediated Vascular Calcification.
Cell type: general | Technique: EdU proliferation | Disease/area: cardiovascular, diabetes | Acta physiologica (Oxford, England) (2025)
Vascular calcification (VC), a characteristic feature of peripheral artery disease in patients with diabetes and chronic kidney disease, has been associated with poor prognosis. We hypothesize that hyperglycemia drives VC through alterations in metabolomic and
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B10 Promotes Polarization and Pro-Resolving Functions of Bone Marrow Derived Macrophages (BMDM) Through PD-1 Activation.
Cell type: macrophage | Technique: EdU proliferation, knockout | Disease/area: bone disease, inflammation | Cells (2025)
Regulatory B cells (B regs) are immune cells that help suppress excessive inflammatory responses by interacting with other immune components. Among them, B-10 cells are known for their strong immunoregulatory function. This study focused on how B-10 cells infl
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Rat Hair Follicle Stem Cell-Derived Exosomes: Isolation, Characterization and Comparative Analysis of Their In Vitro Wound Healing Potential.
Cell type: general | Technique: wound healing | Disease/area: wound healing | International journal of molecular sciences (2025)
Stem cell-derived secretome and exosomes present a promising cell-free strategy for tissue repair and wound healing. This study aimed to isolate and characterize, for the first time, exosomes derived from rat hair follicle stem cells (rHFSCs) and to evaluate t
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Role of progesterone action in inguinal hernia formation via skeletal muscle fibrosis and atrophy.
Cell type: fibroblast | Technique: general | Disease/area: fibrosis | JCI insight (2025)
More than 1 in 4 men will undergo surgery for inguinal hernia, which is commonly associated with fibrotic degeneration of the lower abdominal muscle (LAM) in the groin region. Utilizing a male mouse model expressing the human aromatase gene (Aromhum), previous
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Engineered bone-targeting apoptotic vesicles as a minimally invasive nanotherapy for heterotopic ossification.
Cell type: general | Technique: general | Disease/area: bone disease | Journal of nanobiotechnology (2025)
Heterotopic Ossification (HO), refers to pathological extra skeletal bone formation, and there are currently no reliable methods except surgery to reverse these unexpected calcified tissues. Apoptotic vesicles (ApoEVs) are membrane-bound vesicles released by a
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Effect of CTMP1 gene on pulmonary fibrosis.
Cell type: A549, epithelial | Technique: EdU proliferation | Disease/area: fibrosis | Toxicological research (2025)
Protein kinase B (PKB/AKT) is a very important member of the protein kinase family, playing significant roles in various crucial processes including insulin-signaling, cell survival, growth, and metabolism. The carboxyl-terminal modulator protein 1 (CTMP1) inh
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Osteo-inductive potential of homoeopathy potencies of Asafoetida on multipotent mesenchymal stem cells in vitro.
Cell type: MSC, cell line | Technique: general | Disease/area: bone disease | 3 Biotech (2025)
The musculoskeletal system is the main framework of the human system. Poor osteogenesis is related to poor diet, improper exercise, autoimmune diseases, or age-related conditions. This tends to compromise the quality of human life, especially gait and mobility
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Human dermal fibroblast senescence in response to single and recurring oxidative stress.
Cell type: fibroblast | Technique: EdU proliferation | Disease/area: skin disease | Frontiers in aging (2025)
(Abstract unavailable)
Google Scholar | PubMed | PMC | DOI
Obese Adipose Tissue Extracellular Vesicles Activate Mitochondrial Fatty Acid β-oxidation to Drive Colonic Stemness.
Cell type: adipocyte, epithelial | Technique: EdU proliferation | Disease/area: obesity | Cellular and molecular gastroenterology and hepatology (2025)
Patients with obesity and mouse models of obesity exhibit abnormalities in intestinal epithelial cells, including enhanced stemness. Adipose tissue (AT) is the largest endocrine organ secreting cytokines, hormones, and extracellular vesicles (EVs). Here, we ch
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Circulating Extracellular Vesicles as Putative Mediators of Cardiovascular Disease in Paediatric Chronic Kidney Disease.
Cell type: endothelial | Technique: general | Disease/area: cardiovascular | Journal of extracellular vesicles (2025)
Cardiovascular disease (CVD) is the leading cause of mortality in chronic kidney disease (CKD). However, the pathogenesis of CVD in CKD remains incompletely understood. Endothelial extracellular vesicles (EC-EVs) have previously been associated with CVD. We hy
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Endothelial cell Piezo1 promotes vascular smooth muscle cell differentiation on large arteries.
Cell type: endothelial | Technique: knockout | Disease/area: cardiovascular | European journal of cell biology (2025)
Vascular stabilization is a mechanosensitive process, in part driven by blood flow. Here, we demonstrate the involvement of the mechanosensitive ion channel, Piezo1, in promoting arterial accumulation of vascular smooth muscle cells (vSMCs) during zebrafish de
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Varying Properties of Extracellular Matrix Grafts Impact Their Durability and Cell Attachment and Proliferation in an
Cell type: T cell | Technique: EdU proliferation, wound healing | Disease/area: inflammation, wound healing | Journal of tissue engineering and regenerative medicine (2024)
While acute wounds typically progress through the phases of wound healing, chronic wounds often stall in the inflammatory phase due to elevated levels of matrix metalloproteinases (MMPs) and proinflammatory cytokines. Dysregulated expression of MMPs can result
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Activation of a GPCR, ORL1 Receptor: A Novel Therapy to Prevent Heart Failure Progression.
Cell type: general | Technique: EdU proliferation | Disease/area: cardiovascular | Journal of cardiovascular development and disease (2024)
The number of ischemic heart failure (HF) patients is growing dramatically worldwide. However, there are at present no preventive treatments for HF. Our previous study showed that Gata4 overexpression improved cardiac function after myocardial infarction in ra
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Extracellular Vesicles Derived From
Cell type: macrophage | Technique: general | Disease/area: cardiovascular | Journal of parasitology research (2024)
Recent studies have shown that extracellular vesicles (EVs) secreted by various parasites are capable of modulating the host's innate immune responses, such as by altering macrophage (M
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Co-Delivery of Valsartan and Metformin from a Thermosensitive Hydrogel-Nanoparticle System Promotes Collagen Production in Proliferating and Senescent Primary Human Dermal Fibroblasts.
Cell type: T cell, fibroblast | Technique: EdU proliferation | Disease/area: skin disease, wound healing | Biomacromolecules (2024)
Aging negatively impacts skin health, notably through the senescent cell phenotype, which reduces collagen production and leads to thinner, more fragile skin prone to injuries and chronic wounds. We designed a drug delivery system that addresses these age-rela
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Short-term therapy with R568 ameliorated secondary hyperparathyroidism but does not prevent aortic valve calcification in uremic rats.
Cell type: general | Technique: general | Disease/area: cardiovascular | Frontiers in nephrology (2024)
Renal failure associated aortic valve calcification (AVC) is the result of hyperphosphatemia and hyperparathyroidism. Calcimimetics is an effective tool for management of secondary hyperparathyroidism. Our goal was to evaluate the effect of the medical interve
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A novel ABCC9 variant in a Greek family with Cantu syndrome affecting multiple generations highlights the functional role of the SUR2B NBD1.
Cell type: general | Technique: general | Disease/area: cardiovascular | American journal of medical genetics. Part A (2024)
Cantu syndrome (CS) (OMIM #239850) is an autosomal dominant multiorgan system condition, associated with a characteristic facial phenotype, hypertrichosis, and multiple cardiovascular complications. CS is caused by gain-of-function (GOF) variants in KCNJ8 or A
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Enhanced Cardiomyocyte NLRP3 Inflammasome-Mediated Pyroptosis Promotes d-Galactose-Induced Cardiac Aging.
Cell type: cardiomyocyte, cell line | Technique: EdU proliferation, knockout | Disease/area: cardiovascular | Journal of the American Heart Association (2024)
Cardiac aging represents an independent risk factor for aging-associated cardiovascular diseases. Although evidence suggests an association between NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome formation and numerous cardiovascular dis
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Methionine sulfoxide reductase B2 protects against cardiac complications in diabetes mellitus.
Cell type: cardiomyocyte | Technique: EdU proliferation, knockout | Disease/area: cardiovascular, diabetes, fibrosis | Diabetology & metabolic syndrome (2024)
Diabetes mellitus (DM) is a progressive, chronic metabolic disorder characterized by high oxidative stress, which can lead to cardiac damage. Methionine sulfoxylation (MetO) of proteins by excessive reactive oxygen species (ROS) can impair the basic functional
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Enhanced chondrogenic potential in GelMA-based 3D cartilage model via Wnt3a surface immobilization.
Cell type: MSC, cell line | Technique: general | Disease/area: arthritis, bone disease | Scientific reports (2024)
Cartilage tissue engineering aims to develop functional substitutes for treating cartilage defects and osteoarthritis. Traditional two-dimensional (2D) cell culture systems lack the complexity of native cartilage, leading to the development of 3D regenerative
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Assessing the effects of bladder decellularization protocols on extracellular matrix (ECM) structure, mechanics, and biology.
Cell type: general | Technique: general | Disease/area: wound healing | Journal of pediatric urology (2024)
Acellular matrices have historically been applied as biologic scaffolds in surgery, wound care, and tissue engineering, albeit with inconsistent outcomes. One aspect that varies widely between products is the selection of decellularization protocol, yet few st
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Protocols for collecting mouse PDL cells and bone marrow cells, differentiation, and data analysis.
Cell type: T cell, macrophage | Technique: general | Disease/area: bone disease | STAR protocols (2024)
Periodontal ligament cells (PDLCs) and macrophages in bone marrow cells have been widely used to investigate novel therapeutic agents to treat periodontitis. Here, we present a protocol for collecting primary mouse PDLCs and bone marrow cells. We detail steps
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An Integrative Transcriptome Subtraction Strategy to Identify Human lncRNAs That Specifically Play a Role in Activation of Human Hepatic Stellate Cells.
Cell type: general | Technique: CRISPR, EdU proliferation | Disease/area: cardiovascular, fibrosis | Non-coding RNA (2024)
Fibrotic liver features excessive deposition of extracellular matrix (ECM), primarily produced from "activated" hepatic stellate cells (HSCs). While targeting human HSCs (hHSCs) in fibrosis therapeutics shows promise, the overall understanding of hHS
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Disrupting TSLP-TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases.
Cell type: general | Technique: general | Disease/area: skin disease | EMBO molecular medicine (2024)
Thymic stromal lymphopoietin (TSLP) is a key player in atopic diseases, which has sparked great interest in therapeutically targeting TSLP. Yet, no small-molecule TSLP inhibitors exist due to the challenges of disrupting the protein-protein interaction between
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Characterization of a phenol-based model for denervation of the abdominal aorta and its implications for aortic remodeling.
Cell type: general | Technique: EdU proliferation, immunohistochemistry | Disease/area: cardiovascular | JVS-vascular science (2024)
Sympathetic innervation plays a pivotal role in regulating cardiovascular health, and its dysregulation is implicated in a wide spectrum of cardiovascular diseases. This study seeks to evaluate the impact of denervation of the abdominal aorta on its morphology
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Functional and Molecular Analysis of Human Osteoarthritic Chondrocytes Treated with Bone Marrow-Derived MSC-EVs.
Cell type: general | Technique: EdU proliferation | Disease/area: arthritis, bone disease, inflammation | Bioengineering (Basel, Switzerland) (2024)
Osteoarthritis (OA) is a degenerative joint disease, causing impaired mobility. There are currently no effective therapies other than palliative treatment. Mesenchymal stromal cells (MSCs) and their secreted extracellular vesicles (MSC-EVs) have shown promise
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The Impact of High Adiposity on Endometrial Progesterone Response and Metallothionein Regulation.
Cell type: epithelial | Technique: general | Disease/area: obesity | The Journal of clinical endocrinology and metabolism (2024)
Obesity is a disease with deleterious effects on the female reproductive tract, including the endometrium. We sought to understand the effects of excess adipose on the benign endometrium. A physiologic in vitro coculture system was developed, consisting of mul
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PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.
Cell type: general | Technique: general | Disease/area: cardiovascular | Nature communications (2024)
Proper placental development in early pregnancy ensures a positive outcome later on. The developmental relationship between the placenta and embryonic organs, such as the heart, is crucial for a normal pregnancy. However, the mechanism through which the placen
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Homocysteine potentiates amyloid
Cell type: endothelial | Technique: general | Disease/area: Alzheimer disease, cardiovascular | Aging cell (2024)
Cerebrovascular dysfunction has been implicated as a major contributor to Alzheimer's Disease (AD) pathology, with cerebral endothelial cell (cEC) stress promoting ischemia, cerebral-blood flow impairments and blood-brain barrier (BBB) permeability. Recen
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Irisin Enhances Mitochondrial Function in Osteoclast Progenitors during Differentiation.
Cell type: general | Technique: general | Disease/area: bone disease | Biomedicines (2023)
Irisin is a myokine released from muscle during exercise with distinct signaling effects on tissues throughout the body, including an influence on skeletal remodeling. Our previous work has shown that irisin stimulates resorption, a key first step in bone remo
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