NeuroImmune Pharmacology and Therapeutics 2024
Sera from people with HIV and depression induce commensurate metabolic alterations in astrocytes: toward precision diagnoses and therapies.
CellInsight CX5
Used the CellInsight CX5 High Content Screening platform to quantify astrocyte metabolic alterations induced by sera from people with HIV and depression, linking immunometabolic changes to depressive symptoms and cognitive function.
2026 ACS nanoscience Au — Stem Cells and Regenerative Medicine
Ultrasound-Generated Nanoscale Mechanical Stimulation to Regulate Stem Cell Differentiation.
EVOS M5000
Harnessing nanoscale mechanical cues to direct stem cell fate represents a transformative strategy in cell-engineered tissue regeneration. In this study, we demonstrate that low-frequency ultrasound (LFU) induces nanoscale vertical displacements (30-65 nm) at…
2026 In vivo (Athens, Greece) — Cell Biology
Lenvatinib Suppresses Colorectal Cancer Cell Growth, Migration, and Invasion
EVOS M5000
Colorectal cancer (CRC) remains a major cause of cancer mortality. Lenvatinib, a multi-kinase inhibitor, has emerging anticancer potential, but its effects in CRC are not fully defined. The aim of this study was to identify potential treatment mechanism and…
2025 Scientific reports — Infectious and Immunology
Benzydamine rescues ethanol-induced teratogenesis in zebrafish FASD model.
EVOS M5000
Fetal alcohol spectrum disorders (FASD) are a group of physical, behavioral, and cognitive impairments caused by ethanol exposure during pregnancy. Zebrafish have emerged as a useful model for researching FASD and its variants in recent years. Oxidative…
2021 Frontiers in oncology — Cancer
The c-Myc/TBX3 Axis Promotes Cellular Transformation of Sarcoma-Initiating Cells.
EVOS M5000
Sarcomas are highly aggressive cancers of mesenchymal origin whose clinical management is highly complex. This is partly due to a lack of understanding of the molecular mechanisms underpinning the transformation of mesenchymal stromal/stem cells (MSCs) which…
2023 Animals : an open access journal from MDPI — Tissue and Disease Models
In Vivo and In Vitro Expression of iC1, a Methylation-Controlled J Protein (MCJ) in Bovine Liver, and Response to In Vitro Bovine Fatty Liver Disease Model.
EVOS M5000
Mitochondrial complex I inhibitor (iC1) is a methylation-controlled J protein (MCJ) that decreases cellular respiration by inhibiting oxidative phosphorylation. Recent rodent studies showed that loss or inhibition of iC1 was associated with preventing lipid…
2025 Current issues in molecular biology — Skin and Biomaterials
Morphological and Molecular Characterization of Apple Scab (
EVOS M5000
Apple scab, caused by the fungus
2025 International journal of molecular sciences — Imaging Methods
<i>Mentha rotundifolia</i>, a Source of Amoebicidal Agents Against <i>Naegleria fowleri</i>.
EVOS M5000
Current therapies for Primary Amoebic Meningoencephalitis (PAM) present several limitations; consequently, there is an urgent need to develop new therapeutic agents. In this regard, we undertook bioassay-guided isolation of
2026 Materials today. Bio — Toxicology and Environmental
Graphene oxide-microplastic hybrid showcase elicited discrepancy through intrinsic interaction mediated steatosis, and apoptosis in macrophages.
EVOS M5000
The widespread natural abundance of microplastics (MP) has been recognized to pose significant global health concerns, particularly due to limited understanding of their biological interactions. With the uncontrolled increase in MP accumulation in the…
2025 STAR protocols — Neuroscience
Protocol for extraction and characterization of mouse brain-derived extracellular matrix for neuronal cell culture.
EVOS M5000
Neuronal cell cultures are highly sensitive to their microenvironment, particularly the choice of coating substrate. Here, we present a protocol to isolate extracellular matrix (ECM) from mouse brain tissue, providing a native coating material that closely…
2025 PLoS pathogens — Infectious and Immunology
Filovirus infection disrupts epithelial barrier function and ion transport in human iPSC-derived gut organoids.
EVOS M5000
Gastrointestinal (GI) dysfunction, characterized by severe diarrhea and dehydration, is a central contributor to morbidity and mortality in filovirus disease in patients, yet the role of the epithelium in this clinical outcome remains poorly defined. Here, we…
2026 ChemistryOpen — Cell Biology
Integrated In Silico and In Vitro Study of Copper Nanocatalyzed Carbonyl-Functionalized Triazoles-Inducing S Phase Cell Cycle Arrest and Apoptosis in MCF-7.
EVOS M5000
The demand for novel, selective anticancer agents, driven by drug resistance and systemic toxicity of current treatments, underscores the importance of targeted drug discovery. Present research involved cytotoxic screening of a series of synthesized copper…
2026 Probiotics and antimicrobial proteins — Infectious and Immunology
Antagonistic Mechanisms of Probiotic Aliivibrio sp. Strain Vl2 Against Moritella viscosa: Evidence from Co-cultivation and Targeted Transcriptomic Analysis.
EVOS M5000
Winter ulcers, primarily caused by Moritella viscosa, represent a significant challenge for the Norwegian aquaculture industry. Effective control measures are hampered by the lack of effective vaccines and limited use of antibiotics, driven by the global…
Imaging technique: high-content imaging
BRD1 haploinsufficiency alters early neuronal programming and disrupts maturation in human induced glutamatergic neurons.
CellInsight CX7
Cell type: stem cells, neurons
Imaging technique: high-content imaging, confocal microscopy
Abnormal Lipid Signaling Characterizes Diastolic Dysfunction in Pediatric Cardiomyopathy.
CellInsight CX7
Cell type: stem cells, iPSCs, fibroblasts
Imaging technique: confocal microscopy
Comparative lipidomics of iPSC-derived microglia protocols reveal lipid droplet and immune differences mediated by media composition.
CellInsight CX7
Cell type: stem cells, iPSCs, fibroblasts, macrophages, neurons
Imaging technique: high-content imaging
Functional implications of polygenic risk for schizophrenia in human neurons.
CellInsight CX7
Cell type: stem cells, iPSCs, fibroblasts, neurons
Imaging technique: fluorescence microscopy
Dynamic neuro-immune regulation of psychiatric risk loci in human neurons.
CellInsight CX7
Cell type: stem cells, iPSCs, fibroblasts, macrophages, neurons, epithelial cells
Imaging technique: fluorescence microscopy, high-content imaging, brightfield microscopy
Uncovering plaque-glia niches in human Alzheimer's disease brains using spatial transcriptomics.
CellInsight CX7
Cell type: stem cells, iPSCs, neurons, endothelial cells
Imaging technique: high-content imaging, confocal microscopy
High-throughput High Content Quantification of HIV-1 Viral Infectious Output.
CellInsight CX7
Cell type: HEK293 cells, primary cells, macrophages
Imaging technique: live-cell imaging, high-content imaging, confocal microscopy
Polyalanine Expansion in PABPN1 Alters the Structure and Dynamics of Its Nuclear Aggregates in Differentiated Muscle Cells.
CellInsight CX7
Cell type: HeLa cells, stem cells, neurons
Imaging technique: high-content imaging
Microfluidic-Chip-Based Formulation and In Vivo Evaluations of Squalene Oil Emulsion Adjuvants for Subunit Vaccines.
CellInsight CX7
Cell type: epithelial cells
Imaging technique: high-content imaging
High-Content Imaging-Based Assay for SARS-CoV-2-Neutralizing Antibodies.
CellInsight CX7
Cell type: HEK293 cells
Imaging technique: fluorescence microscopy, high-content imaging
ADAR1 Biology Can Hinder Effective Antiviral RNA Interference.
CellInsight CX7
Cell type: HEK293 cells, A549 lung cancer cells, stem cells, fibroblasts, neurons, epithelial cells
Imaging technique: live-cell imaging, high-content imaging, confocal microscopy, Z-stack imaging
Structurally and Morphologically Distinct Pathological Tau Assemblies Differentially Affect GVB Accumulation.
CellInsight CX7
Cell type: neurons
Imaging technique: high-content imaging, confocal microscopy
Electroactive Materials Surface Charge Impacts Neuron Viability and Maturation in 2D Cultures.
CellInsight CX7
Cell type: SH-SY5Y neuroblastoma cells, stem cells, neurons
Imaging technique: high-content imaging
Non-additive effects of schizophrenia risk genes reflect convergent downstream function.
CellInsight CX7
Cell type: stem cells, iPSCs, neurons
Imaging technique: high-content imaging
Tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations.
CellInsight CX7
Cell type: HeLa cells
Imaging technique: live-cell imaging, high-content imaging
Sterol dysregulation in Smith-Lemli-Opitz syndrome causes astrocyte immune reactivity through microglia crosstalk.
CellInsight CX7
Cell type: stem cells, macrophages, neurons
Imaging technique: high-content imaging, confocal microscopy, Z-stack imaging
Granulovacuolar degeneration bodies are independently induced by tau and α-synuclein pathology.
CellInsight CX7
Cell type: HeLa cells, HEK293 cells, iPSCs, neurons
Imaging technique: fluorescence microscopy
Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression.
CellInsight CX7
Cell type: stem cells, iPSCs, fibroblasts, neurons, keratinocytes, endothelial cells
Placenta · 2026 · 3D vascular imaging · Tissue clearing
Clearing for insight: A light-sheet microscopy workflow for 3D vascular reconstruction in human first trimester placental villi and decidua
EVOS M5000
This study combines optical clearing with light-sheet microscopy to map the 3D vascular architecture of first-trimester placental villi and decidua. It is a powerful demonstration of why thick placental tissue needs sectioning-free 3D methods, but the same groups typically use widefield inverted ...
Placenta · 2026 · 3D vascular mapping · Tissue clearing
Tissue clearing and light-sheet fluorescence microscopy for three-dimensional mapping of placental vascularization
EVOS M5000
Another recent clearing/light-sheet paper focused on reconstructing placental vascular networks in 3D. The workflow highlights how immunofluorescence staining quality on flat sections or cultured trophoblasts — a step often done on an EVOS M5000 — directly feeds into the final 3D render quality. ...
Microscopy Research and Technique · 2004 · Pre-eclampsia · Confocal immunofluorescence
Confocal laser scanning microscope study of cytokeratin immunofluorescence differences between villous and extravillous trophoblast: Cytokeratin downregulation in pre-eclampsia
EVOS M5000
A classic confocal study comparing cytokeratin expression in villous versus extravillous trophoblast in normal and pre-eclamptic placentas. The same immunofluorescence panels (CK7, CK8/18, nuclear counterstain) can be captured on an EVOS M5000 for routine trophoblast phenotype checks, reserving c...
Placenta · 2024 · Trophoblast differentiation · Quantitative image analysis
A quantitative image analysis platform for assessing trophoblast differentiation
EVOS M5000
This paper directly addresses the challenge of turning trophoblast immunofluorescence images into quantitative differentiation metrics. The EVOS M5000's automated cell counting and confluence tools map well onto this kind of assay: capture multi-channel images of syncytialisation or extravillous ...
American Journal of Reproductive Immunology · 2012 · Mouse placenta · Intravital imaging
In vivo multiphoton microscopy technique to reveal the physiology of the mouse placenta
EVOS M5000
A multiphoton intravital imaging study that tracks placental blood flow and cell dynamics in living mice. This is specialist territory — far beyond a benchtop inverted microscope — but the explant and organoid prep work that leads into it (staining, marker validation, baseline morphology) is exac...
Science Advances · 2024 · Live imaging · Placental development
Longitudinal intravital imaging of mouse placenta
EVOS M5000
A 2024 study using longitudinal intravital imaging to follow mouse placental development over time. The high-resolution, deep-tissue work needs multiphoton or light-sheet instrumentation, yet the same group will typically use an automated inverted imager such as the EVOS M5000 or M7000 for fixed-...
Medicine · 2018 · Placental vascular imaging · Tissue clearing
Optical tissue clearing in combination with perfusion and immunofluorescence for placental vascular imaging
EVOS M5000
This protocol paper describes how to clear and immunolabel whole placental tissue for vascular imaging. It is a useful reminder that high-quality 2D immunofluorescence on sections or cultured trophoblasts — the domain of the EVOS M5000 — is the foundation for any 3D clearing experiment. Poor anti...
Imaging technique: Fluorescence/senescence imaging
Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression.
EVOS M5000
Cell type: Endothelial cells
Imaging technique: Brightfield/fluorescence imaging
Dysfunction of iPSC-derived endothelial cells in human Hutchinson-Gilford progeria syndrome.
EVOS M5000
Cell type: iPSC-derived endothelial cells
Imaging technique: 3D hydrogel encapsulation, live-cell imaging
Three-dimensional encapsulation of adult mouse cardiomyocytes in hydrogels with tunable stiffness.
EVOS M5000
Cell type: Adult mouse cardiomyocytes
Imaging technique: Exosome/vesicle imaging, fluorescence
Endothelial cell-derived extracellular vesicles alter vascular smooth muscle cell phenotype through high-mobility group box proteins.
EVOS M5000
Cell type: Endothelial cells and vascular smooth muscle cells
Imaging technique: Live-cell / fluorescence imaging
STAT3-induced up-regulation of lncRNA NEAT1 as a ceRNA facilitates abdominal aortic aneurysm formation by elevating TULP3.
EVOS M5000
Cell type: Vascular smooth muscle cells / aortic tissue
Imaging technique: Fluorescence microscopy (photodynamic therapy)
Ferroptosis with Contributions from Apoptosis and Necroptosis in Porphyrazine III-Based Photodynamic Therapy of Primary Human Gliomas.
EVOS M5000
Cell type: Primary human glioma cells
Imaging technique: 3D tumor-stroma microtissue / high-content on-chip imaging
Genipin-Crosslinked, Silane-Anchored 3D Tumor-Stroma Microtissues for High-Content On-Chip Drug Testing.
EVOS M5000
Cell type: Tumor cells + cancer-associated fibroblasts (CAFs)
Imaging technique: Fluorescence microscopy
Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation.
EVOS M5000
Cell type: Cancer cells / OST-engineered cell lines
Imaging technique: Live-cell imaging of stiffness / ion channels
Ionic regulation of cancer cell stiffness and metastatic colonization via the MRTFA-KCNMB1 axis.
EVOS M5000
Cell type: Cancer cells (breast / metastatic)
Imaging technique: Fluorescence / live-cell imaging
TRIM26-mediated NKRF degradation drives Osimertinib resistance through SNRPD2-dependent stress granule formation in lung adenocarcinoma.
EVOS M5000
Cell type: Lung adenocarcinoma cells
Imaging technique: Fluorescence microscopy (ferroptosis assays)
Protein kinase A regulates ferroptosis by controlling GPX4 m(6)A modification through phosphorylation of ALKBH5.
EVOS M5000
Cell type: Cancer cells
Imaging technique: Imaging / single-cell transcriptomics validation
Single-cell transcriptomics reveals FXR1 as an actionable target for siRNA therapy in ovarian cancer.
EVOS M5000
Cell type: Ovarian cancer cells
Imaging technique: Fluorescence / cell-death imaging
DNA replication stress and translational repression converge to drive CDK1- and caspase-dependent apoptosis in Ewing sarcoma.
EVOS M5000
Cell type: Ewing sarcoma cells
Imaging technique: Migration/invasion / live-cell imaging
HIF-1-regulated TPM3 links hypoxia to motility and invasion beyond the hypoxic fraction in triple-negative breast cancer.
EVOS M5000
Cell type: Triple-negative breast cancer cells
Imaging technique: Fluorescence / signaling imaging
Modulation of the endocannabinoid system reduces inflammatory signalling in canine mammary carcinoma cells.
EVOS M5000
Cell type: Canine mammary carcinoma cells
Imaging technique: Live-cell / fluorescence imaging (BBB integrity, angiogenesis)
Alzheimer's amyloid ß heterogeneous species differentially affect brain endothelial cell viability, blood-brain barrier integrity, and angiogenesis.
EVOS M5000
Cell type: Brain endothelial cells
Imaging technique: Histology / fluorescence imaging
TLR2 deficiency attenuated chronic intermittent hypoxia-induced neurocognitive deficits.
EVOS M5000
Cell type: Neurons / microglia
Imaging technique: Fluorescence imaging (oxidative stress, apoptosis)
Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1a Signaling Pathways Mediated by the NAMPT-NAD Pathway.
EVOS M5000
Cell type: Neurons
Imaging technique: Optical sensing / fluorescence (aptasensor)
High-Performance Conducting Polymer Nanotube-based Liquid-Ion Gated Field-Effect Transistor Aptasensor for Dopamine Exocytosis.
EVOS M5000
Cell type: PC12 / neuronal cells
2025 Journal of Immunology abstract describing a streamlined multiplex immunohistochemistry workflow for spatial analysis of tumor microenvironments and disease states. The work aligns with the EVOS S1000 ’s role in making multiplex tissue imaging accessible for translational immuno-oncology studies.
Streamlined spatial analysis of the tumor microenvironment and associated disease states using multiplex immunohistochemistry
EVOS S1000
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2025 Journal of Immunology abstract on high-plex fluorescent labeling and spectral unmixing to phenotype tumor microenvironments. The approach matches the spectral multiplexing and unmixing capabilities built into the EVOS S1000 Spatial Imaging System.
Cellular phenotyping of tumor microenvironments with a high-plex fluorescent labeling and spectral unmixing approach
EVOS S1000
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2020 PLOS One methods article presenting a high-throughput imaging and quantification pipeline built around the EVOS imaging platform. While published before the S1000 launch, the pipeline principles — batch acquisition, standardised export formats and automated quantification — are directly applicable to EVOS S1000 spatial-imaging workflows.
a high-throughput imaging and quantification pipeline for the EVOS imaging platform
EVOS S1000
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2024 feature in The Pathologist discussing how the EVOS S1000 Spatial Imaging System improves scanning and processing of stained multiplexed tissue samples. The article highlights faster slide scanning, cleaner unmixing and a biology-focused interface for pathology and spatial-biology labs.
Moving forward with multiplexing
EVOS S1000
Read the article
2025 KTH Royal Institute of Technology thesis evaluating antibody-labelling kits for multiplex imaging of tissue sections. The work supports the reagent-validation step that underpins reliable multiplex immunofluorescence on spatial imaging systems such as the EVOS S1000.
Evaluation of antibody labelling kits for multiplex imaging of tissue sections
EVOS S1000
Read the thesis
2024 KTH thesis exploring how protein-interaction data and cellular phenotyping can together predict immunotherapy response in metastatic bladder cancer. The phenotyping layer is conceptually aligned with high-plex spatial imaging workflows such as those enabled by the EVOS S1000.
Combining protein interactions with cellular phenotyping to predict response to immunotherapy
EVOS S1000
Read the thesis
2025 on-demand webinar from LabRoots featuring Thermo Fisher Scientific, focused on how the EVOS S1000 simplifies spatial proteomics entry for translational research. It covers 9-plex spectral fluorescence imaging, tissue-slide workflows and rapid data generation compared to traditional spatial platforms.
Accelerate and simplify spatial proteomics for translational research with the EVOS S1000 Spatial Imaging System
EVOS S1000
Watch the webinar
2025 technology spotlight demonstrating spectral multiplex fluorescence imaging on the EVOS S1000. The presentation focuses on practical panel design, spectral unmixing and generating high-quality spatial protein maps without the complexity of a core-facility instrument.
Spectral multiplex fluorescence imaging with the Invitrogen EVOS S1000 system
EVOS S1000
Watch the spotlight
2025 Frontiers in Artificial Intelligence brief report that predicts DAPI and other fluorescent markers directly from brightfield EVOS M5000 images of bovine satellite cells using an U-Net convolutional neural network. It demonstrates how the EVOS M5000 can be used as a non-invasive imaging platform to train AI models that reduce the need for destructive fluorescent staining in cultured-cell quality control.
Fluorescent marker prediction for non-invasive optical imaging in bovine satellite cells using deep learning
EVOS M5000
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2025 Journal of Pharmaceutical Sciences study that used the EVOS M5000 to image mammalian cells and evaluate improvements in viral gene-delivery efficiency after co-incubation with transportan peptide. The work shows how routine fluorescence imaging on the EVOS M5000 supports quantitative readouts in gene-therapy process development.
Improving viral-based gene delivery to mammalian cells through simple co-incubation with transportan peptide in vitro
EVOS M5000
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2025 open-access research article from St George’s, University of London, describing single-cycle PIV5 vectors engineered for recombinant protein production. Fluorescence imaging performed on the EVOS M5000 was used to confirm reporter expression and vector transduction in cell culture, illustrating the system’s utility in viral-vector characterisation.
Single-cycle parainfluenza virus type 5 vectors for producing recombinant proteins, including a humanized anti-V5 tag antibody
EVOS M5000
Read the paper | DOI
2025 Journal of Biological Engineering paper that separated dental-pulp mesenchymal stromal-cell subpopulations by size and then used the EVOS M5000 for downstream fluorescence imaging to confirm cell identity and functional differences. The study highlights how the EVOS M5000 supports cell-therapy and regenerative-medicine characterisation workflows.
Harnessing cell size to separate genetically and functionally distinct dental pulp-derived mesenchymal stromal cell subpopulations
EVOS M5000
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2025 virology study that employed the EVOS M5000 to image bovine cells during early Epizootic Haemorrhagic Disease Virus infection. The microscope helped visualise viral entry and the impact of endosome-modulating compounds, demonstrating its value in infection-biology time-course imaging.
Inhibition of early EHDV2-Ibaraki infection steps in bovine cells by endosome alkalinization or ikarugamycin, but not by blockage of individual endocytic pathways
EVOS M5000
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2025 Research Square preprint that used the EVOS M5000 to image nanoplastic uptake and toxicity in kidney cell cultures across different particle sizes and polymer chemistries. The work shows the system’s application in environmental toxicology and high-content phenotyping.
Nanoplastic toxicity and uptake in kidney cells: differential effects of concentration, particle size, and polymer type
EVOS M5000
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2025 Research Square preprint investigating an Alzheimer’s-related APPswe mutation in iPSC-derived endothelial cells. The EVOS M5000 was used for live-cell and fluorescence imaging to assess endothelial morphology and functional markers, linking the microscope to neurovascular disease modelling.
APPswe mutation causes functional deficits in endothelial cells generated by transient ETV2 overexpression in human iPSCs
EVOS M5000
Read the paper | DOI
2026 ACS Omega article on extracellular-vesicle characterisation. The EVOS M5000 was used alongside nanoparticle-tracking analysis to image and validate organelle-specific dye labelling of EVs, supporting multi-modal analytical workflows in nanomedicine.
Detection of Organelle-Specific Dyes Labeled Extracellular Vesicles with Colocalization-Fluorescence Nanoparticle Tracking Analysis
EVOS M5000
Read the paper | DOI
Imaging technique: live-cell imaging, confocal microscopy, brightfield microscopy
A reversible broad-spectrum antiviral targets the human V-ATPase VO domain.
CellInsight CX7
Cell type: HEK293 cells, A549 lung cancer cells, primary cells, stem cells, epithelial cells
Imaging technique: high-content imaging
Single-cell transcriptomics uncovers heterogenous cell clusters and the biomarker FUT11 in ovarian cancer progression.
CellInsight CX7
Cell type: fibroblasts, macrophages, endothelial cells, epithelial cells
Imaging technique: fluorescence microscopy, high-content imaging, confocal microscopy
A role for CASM in the repair of damaged Golgi architecture.
CellInsight CX7
Cell type: HeLa cells, HEK293 cells, macrophages, neurons
Imaging technique: high-content imaging
Identification of host lncRNAs that impact Venezuelan equine encephalitis virus TC-83 replication.
CellInsight CX7
Cell type: A549 lung cancer cells, primary cells, neurons
Imaging technique: high-content imaging
Computational epitope heterogeneity analysis in immunostainings from antibody-dilution series.
CellInsight CX7
Cell type: HeLa cells, neurons
Imaging technique: high-content imaging, brightfield microscopy
RNA editing for the treatment of alpha-1 antitrypsin deficiency.
CellInsight CX7
Cell type: stem cells, iPSCs, hepatocytes
Imaging technique: confocal microscopy
Interleukin-7R and chemokine receptor type 7 differentially regulate metabolism in CD4+ and CD8+ T cells.
CellInsight CX7
Cell type: fibroblasts
Imaging technique: high-content imaging, brightfield microscopy
From in silico prediction to experimental validation: Identification of drugs and novel synergistic combinations that inhibit growth of inflammatory breast cancer cells.
CellInsight CX7
Cell type: MCF-7 breast cancer cells, stem cells, macrophages, epithelial cells
Imaging technique: high-content imaging, confocal microscopy
ATG16L1 controls mammalian vacuolar proton ATPase.
CellInsight CX7
Cell type: HeLa cells, HEK293 cells, macrophages, neurons, epithelial cells
Imaging technique: live-cell imaging, high-content imaging, confocal microscopy
Drug-induced phospholipidosis as an artifact in antiviral drug repurposing.
CellInsight CX7
Cell type: A549 lung cancer cells, HepG2 hepatoma cells, neurons, hepatocytes, epithelial cells
Imaging technique: confocal microscopy
Early intervention with extracellular vesicles derived from human umbilical cord mesenchymal stem cells enhances survival and functional recovery after spinal cord injury in rats.
CellInsight CX7
Cell type: stem cells, macrophages, neurons, endothelial cells
Imaging technique: confocal microscopy
Characterizing and controlling CRISPR repair outcomes in nondividing human cells.
CellInsight CX7
Cell type: primary cells, stem cells, iPSCs, neurons
Imaging technique: fluorescence microscopy, confocal microscopy
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases.
CellInsight CX7
Cell type: stem cells, iPSCs, fibroblasts, macrophages, neurons
Imaging technique: high-content imaging
Host cell and viral protease targets of human SERPINs identified by in silico docking.
CellInsight CX7
Cell type: HEK293 cells, A549 lung cancer cells, macrophages, epithelial cells
Imaging technique: high-content imaging, confocal microscopy
Phosphorylation of plectin by Akt3 promotes triple-negative breast cancer cell invasive migration.
CellInsight CX7
Cell type: HEK293 cells, stem cells
Imaging technique: fluorescence microscopy, live-cell imaging, high-content imaging, confocal microscopy, Z-stack imaging
Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils.
CellInsight CX7
Cell type: HeLa cells, HEK293 cells, SH-SY5Y neuroblastoma cells, stem cells, iPSCs, macrophages, neurons, epithelial cells
Imaging technique: fluorescence microscopy
Exploiting dysregulated iron homeostasis to eradicate persistent high-grade serous ovarian cancer.
CellInsight CX7
Cell type: HeLa cells, stem cells, fibroblasts, epithelial cells
Imaging technique: high-content imaging, confocal microscopy
A role for CASM in the repair of damaged Golgi architecture.
CellInsight CX7
Cell type: HeLa cells, HEK293 cells, macrophages, neurons
Imaging technique: fluorescence microscopy, high-content imaging, confocal microscopy
Identification of SRSF9 through pooled shRNA screening links BNIP3 splicing to autophagy and metabolic reprogramming in breast cancer.
CellInsight CX7
Cell type: HEK293 cells, MCF-7 breast cancer cells, primary cells
Imaging technique: fluorescence microscopy, live-cell imaging, high-content imaging, confocal microscopy
Therapeutic potential of human mesenchymal stromal cell-derived mitochondria in a rat model of surgical digestive fistula.
CellInsight CX7
Cell type: stem cells, fibroblasts, macrophages, neurons, epithelial cells
Imaging technique: fluorescence microscopy
Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys.
CellInsight CX7
Cell type: HeLa cells, stem cells
Imaging technique: fluorescence microscopy
An injectable 2.5% cross-linked polyacrylamide hydrogel (2.5 iPAAG) demonstrates no neurotoxicity in human induced pluripotent stem cells-derived iCell® GlutaNeurons.
CellInsight CX7
Cell type: SH-SY5Y neuroblastoma cells, stem cells, iPSCs, neurons
Imaging technique: fluorescence microscopy, high-content imaging, confocal microscopy
ATG9A facilitates the closure of mammalian autophagosomes.
CellInsight CX7
Cell type: HeLa cells, HEK293 cells, macrophages, neurons, epithelial cells
Imaging technique: high-content imaging
Near Infrared Biomimetic Hybrid Magnetic Nanocarrier for MRI-Guided Thermal Therapy.
CellInsight CX7
Cell type: stem cells, macrophages
Imaging technique: live-cell imaging, high-content imaging, confocal microscopy
A multiparametric anti-aging CRISPR screen uncovers a role for BAF in protein synthesis regulation.
CellInsight CX7
Cell type: primary cells, fibroblasts
Imaging technique: high-content imaging
Serine starvation suppresses the progression of esophageal cancer by regulating the synthesis of purine nucleotides and NADPH.
CellInsight CX7
Cell type: macrophages, neurons
Imaging technique: high-content imaging
AMG 193, a Clinical Stage MTA-Cooperative PRMT5 Inhibitor, Drives Antitumor Activity Preclinically and in Patients with MTAP-Deleted Cancers.
CellInsight CX7
Cell type: macrophages
Imaging technique: time-lapse microscopy, high-content imaging, confocal microscopy, brightfield microscopy
A new class of natural anthelmintics targeting lipid metabolism.
CellInsight CX7
Cell type: cell lines
Imaging technique: high-content imaging
From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 Variants.
CellInsight CX7
Cell type: HEK293 cells, hepatocytes, epithelial cells
Imaging technique: high-content imaging, confocal microscopy
mTORC1 activity oscillates throughout the cell cycle, promoting mitotic entry and differentially influencing autophagy induction.
CellInsight CX7
Cell type: HeLa cells, U2OS osteosarcoma cells, fibroblasts
Imaging technique: confocal microscopy
Effects of zinc in podocytes and cortical collecting duct in vitro and Dahl salt-sensitive rats in vivo.
CellInsight CX7
Cell type: HeLa cells, neurons, epithelial cells
Imaging technique: confocal microscopy
Cytokine-armed pyroptosis induces antitumor immunity against diverse types of tumors.
CellInsight CX7
Cell type: HEK293 cells, primary cells, macrophages
Imaging technique: Fluorescence microscopy
TOPORS, a tumor suppressor protein, contributes to the maintenance of higher-order chromatin architecture.
EVOS M5000
Cell type: Cancer cells (U2OS/HeLa nuclear architecture)
Imaging technique: Viability / fluorescence imaging
The Killing of Human Neuroblastoma Cells by the Small Molecule JQ1 Occurs in a p53-Dependent Manner.
EVOS M5000
Cell type: Neuroblastoma cells (neuronal cancer)
Imaging technique: Migration/invasion assays, live-cell imaging
STAT3-induced long noncoding RNA LINC00668 promotes migration and invasion of non-small cell lung cancer via the miR-193a/KLF7 axis.
EVOS M5000
Cell type: Non-small cell lung cancer cells
Imaging technique: Proliferation/viability, fluorescence imaging
Decreased expression of miR-551b predicts poor prognosis and promotes tumorigenesis by targeting PTP4A3 in human colorectal cancer.
EVOS M5000
Cell type: Colorectal cancer cells
Imaging technique: Metastasis imaging / fluorescence
Transcriptional repression of SIRT3 potentiates mitochondrial aconitase activation to drive aggressive prostate cancer to the bone.
EVOS M5000
Cell type: Prostate cancer cells
Imaging technique: Apoptosis/viability, fluorescence imaging
Hydrazinocurcumin and 5-fluorouracil enhance apoptosis and restrain tumorigenicity of HepG2 cells via disrupting the PTEN-mediated PI3K/Akt signaling pathway.
EVOS M5000
Cell type: HepG2 hepatocellular carcinoma cells
Imaging technique: Live-cell fluorescence (pH sensors)
Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells.
EVOS M5000
Cell type: Pancreatic cancer cells
Imaging technique: Proliferation, fluorescence imaging
TRIM11 promotes breast cancer cell proliferation by stabilizing estrogen receptor a.
EVOS M5000
Cell type: Breast cancer cells (ERα+)
Imaging technique: 3D spheroid, live-cell/fluorescence
Characterization of Uveal Melanoma Cell Lines and Primary Tumor Samples in 3D Culture.
EVOS M5000
Cell type: Uveal melanoma cells
Imaging technique: Viability/proliferation, fluorescence
The intensification of anticancer activity of LFM-A13 by erythropoietin as a possible option for inhibition of breast cancer.
EVOS M5000
Cell type: Breast cancer cells
Imaging technique: Brightfield/phase-contrast morphology imaging
The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse.
EVOS M5000
Cell type: Striated muscle myofibers (mouse panniculus carnosus)
Imaging technique: 3D culture, fluorescence/brightfield imaging
3D Printed Polyurethane Scaffolds for the Repair of Bone Defects.
EVOS M5000
Cell type: Bone marrow mesenchymal stem cells / osteoblasts
Imaging technique: Brightfield/fluorescence imaging
ZNF521 Represses Osteoblastic Differentiation in Human Adipose-Derived Stem Cells.
EVOS M5000
Cell type: Adipose-derived stem cells / osteoblasts
Imaging technique: 3D hydrogel culture, live-cell imaging
Screening method to identify hydrogel formulations that facilitate myotube formation from encapsulated primary myoblasts.
EVOS M5000
Cell type: Primary myoblasts
Imaging technique: Bioluminescence imaging, live-cell
Real-time tracking of stem cell viability, proliferation, and differentiation with autonomous bioluminescence imaging.
EVOS M5000
Cell type: Stem cells (mesenchymal)
Imaging technique: Fluorescence microscopy
Essential oil impregnated luminescent hydroxyapatite: Antibacterial and cytotoxicity studies.
EVOS M5000
Cell type: Bacteria / mammalian cells
Imaging technique: Optical / fluorescence microscopy
Cephalopod-inspired optical engineering of human cells.
EVOS M5000
Cell type: Human cells / tissues
Imaging technique: Live-cell / fluorescence cytotoxicity imaging
Polyvinylidene fluoride-Hyaluronic acid wound dressing comprised of ionic liquids for controlled drug delivery and dual therapeutic behavior.
EVOS M5000
Cell type: Human skin cells / fibroblasts
Imaging technique: Histology / fluorescence imaging
Human skin explant model for the investigation of topical therapeutics.
EVOS M5000
Cell type: Human skin explants (keratinocytes, fibroblasts)
Imaging technique: Exosome imaging / fluorescence
High frequency acoustic cell stimulation promotes exosome generation regulated by a calcium-dependent mechanism.
EVOS M5000
Cell type: Cultured cells (exosome production)
Imaging technique: high-content imaging, confocal microscopy
High-throughput high content quantification of HIV-1 viral infectious output.
CellInsight CX7
Cell type: HEK293 cells, primary cells, macrophages
Imaging technique: high-content imaging, confocal microscopy
TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection.
CellInsight CX7
Cell type: A549 lung cancer cells, epithelial cells
Imaging technique: live-cell imaging, high-content imaging, confocal microscopy
Drug-Induced Phospholipidosis as an Artifact in Antiviral Drug Repurposing.
CellInsight CX7
Cell type: A549 lung cancer cells, HepG2 hepatoma cells, neurons, hepatocytes, epithelial cells
Imaging technique: high-content imaging, confocal microscopy, brightfield microscopy, phase contrast microscopy
Evaluation of a human 3D multicellular hepatic spheroid model as a platform for studying hepatic transporters.
CellInsight CX7
Cell type: stem cells, fibroblasts, hepatocytes, endothelial cells
Imaging technique: fluorescence microscopy, high-content imaging, confocal microscopy
Modeling immune responses of cattle to Mycobacterium bovis using magnetic bioprinted granulomas.
CellInsight CX7
Cell type: primary cells, fibroblasts, macrophages
Imaging technique: high-content imaging
Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance.
CellInsight CX7
Cell type: cell lines
Imaging technique: high-content imaging
Genome-wide analysis of host-encoded microRNAs modulating SARS-CoV-2 infection.
CellInsight CX7
Cell type: HeLa cells, macrophages
Imaging technique: live-cell imaging, time-lapse microscopy, high-content imaging
MicroRNA-142-3p Overcomes Drug Resistance in Hepatocellular Carcinoma by Targeting YES1 and TWF1.
CellInsight CX7
Cell type: stem cells, macrophages, hepatocytes, endothelial cells
Imaging technique: fluorescence microscopy, high-content imaging
An annotated high-content fluorescence microscopy dataset with EGFP-Galectin-3-stained cells and manually labelled outlines.
CellInsight CX7
Cell type: U2OS osteosarcoma cells
Imaging technique: fluorescence microscopy, high-content imaging, confocal microscopy
Mapping spatial organization of in vitro neuronal networks using high-content imaging.
CellInsight CX7
Cell type: primary cells, stem cells, iPSCs, neurons
Imaging technique: high-content imaging
Differential restriction of chikungunya virus in primary human cardiac endothelial cells occurs at multiple steps in the viral life cycle.
CellInsight CX7
Cell type: HeLa cells, HEK293 cells, A549 lung cancer cells, primary cells, iPSCs, fibroblasts, macrophages, endothelial cells
Imaging technique: time-lapse microscopy, confocal microscopy
The effects of Cannabidiol on podocytes in vitro.
CellInsight CX7
Cell type: fibroblasts, neurons, endothelial cells, epithelial cells
Imaging technique: fluorescence microscopy, high-content imaging, confocal microscopy, Z-stack imaging
Short-Term DMOG treatment rejuvenates senescent mesenchymal stem cells by enhancing mitochondrial function and mitophagy through the HIF-1α/BNIP3 pathway.
CellInsight CX7
Cell type: primary cells, stem cells, fibroblasts
Imaging technique: high-content imaging
Seoul orthohantavirus evades innate immune activation by reservoir endothelial cells.
CellInsight CX7
Cell type: HEK293 cells, primary cells, macrophages, endothelial cells
Imaging technique: high-content imaging
The new preservative-free ophthalmic formulation of bilastine 0.6% preserves the ocular surface epithelial integrity in a comparative in vitro study.
CellInsight CX7
Cell type: epithelial cells
Imaging technique: high-content imaging
Long non-coding RNA H19X as a regulator of mononuclear cell adhesion to the endothelium in systemic sclerosis.
CellInsight CX7
Cell type: fibroblasts, endothelial cells
Imaging technique: high-content imaging, confocal microscopy
Neuroprotective mechanisms of luteolin in glutamate-induced oxidative stress and autophagy-mediated neuronal cell death.
CellInsight CX7
Cell type: SH-SY5Y neuroblastoma cells, neurons, endothelial cells
Imaging technique: high-content imaging
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation.
CellInsight CX7
Cell type: HeLa cells, fibroblasts, endothelial cells, epithelial cells
Imaging technique: high-content imaging
Therapeutic efficacy of a potent anti-Venezuelan equine encephalitis virus antibody is contingent on Fc effector function.
CellInsight CX7
Cell type: macrophages
Imaging technique: high-content imaging
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
CellInsight CX7
Cell type: epithelial cells
Imaging technique: fluorescence microscopy
Different Directions of Effects of Polyclonal IgG Antibodies from Patients with Schizophrenia and Healthy Individuals on Cell Death In Vitro: A Pilot Study.
CellInsight CX7
Cell type: SH-SY5Y neuroblastoma cells, fibroblasts, neurons
Imaging technique: fluorescence microscopy, high-content imaging, confocal microscopy
Berbamine suppresses intestinal SARS-CoV-2 infection via a BNIP3-dependent autophagy blockade.
CellInsight CX7
Cell type: HEK293 cells, HepG2 hepatoma cells, primary cells, endothelial cells, epithelial cells
Imaging technique: high-content imaging, confocal microscopy
Discovery of lead natural products for developing pan-SARS-CoV-2 therapeutics.
CellInsight CX7
Cell type: epithelial cells
Imaging technique: high-content imaging
CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.
CellInsight CX7
Cell type: fibroblasts
Imaging technique: high-content imaging, confocal microscopy
The role of small GTPases in bisphenol AF-induced multinucleation in comparison with dibutyl phthalate in the male germ cells.
CellInsight CX7
Cell type: MCF-7 breast cancer cells, stem cells, fibroblasts, endothelial cells
— Cancer
TOPORS, a tumor suppressor protein, contributes to the maintenance of higher-order chromatin architecture.
EVOS M5000
In the nucleus, chromosomes are hierarchically folded into active (A) and inactive (B) compartments composed of topologically associating domains (TADs). Genomic regions interact with nuclear lamina, termed lamina-associated domains (LADs). However, the molecular mechanisms under...
— Cancer
The Killing of Human Neuroblastoma Cells by the Small Molecule JQ1 Occurs in a p53-Dependent Manner.
EVOS M5000
BACKGROUND: MYCN amplification is a prognostic biomarker associated with poor prognosis of neuroblastoma in children. The overall survival of children with MYCN-amplified neuroblastoma has only marginally improved within the last 20 years. The Bromodomain and Extra-Terminal motif...
— Cancer
STAT3-induced long noncoding RNA LINC00668 promotes migration and invasion of non-small cell lung cancer via the miR-193a/KLF7 axis.
EVOS M5000
Long noncoding RNAs (lncRNAs) have been demonstrated to play significant roles in non-small cell lung cancer (NSCLC) progression. Recently, a newly identified lncRNA, LncRNA LINC00668 (LINC00668), was reported to be involved in the regulation of progression of several tumors. How...
— Cell Biology & Signaling
Engineering Intracellular Protein Sensors in Mammalian Cells.
EVOS M5000
Proteins can function as biomarkers of pathological conditions, such as neurodegenerative diseases, infections or metabolic syndromes. Engineering cells to sense and respond to these biomarkers may help the understanding of molecular mechanisms underlying pathologies, as well as ...
— Cell Biology & Signaling
R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling.
EVOS M5000
R-spondins (RSPOs) amplify WNT signaling during development and regenerative responses. We previously demonstrated that RSPOs 2 and 3 potentiate WNT/β-catenin signaling in cells lacking leucine-rich repeat-containing G-protein coupled receptors (LGRs) 4, 5 and 6 (Lebensohn and Ro...
— Cell Biology & Signaling
SON and SRRM2 are essential for nuclear speckle formation.
EVOS M5000
Nuclear speckles (NS) are among the most prominent biomolecular condensates. Despite their prevalence, research on the function of NS is virtually restricted to colocalization analyses, since an organizing core, without which NS cannot form, remains unidentified. The monoclonal a...
— Infectious Disease & Immunology
Negative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain.
EVOS M5000
The B cell adaptor protein (BCAP) is a multimodular regulator of inflammatory signaling in diverse immune system cells. BCAP couples TLR signaling to phosphoinositide metabolism and inhibits MyD88-directed signal transduction. BCAP is recruited to the TLR signalosome forming mult...
— Infectious Disease & Immunology
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
EVOS M5000
Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an in-depth analysis of the tran...
— Infectious Disease & Immunology
Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2.
EVOS M5000
COVID-19 has spread worldwide since 2019 and is now a severe threat to public health. We previously identified the causative agent as a novel SARS-related coronavirus (SARS-CoV-2) that uses human angiotensin-converting enzyme 2 (hACE2) as the entry receptor. Here, we successfully...
2024 PLOS One study that profiled small-molecule effects on HCT116 colorectal cancer cells using the Cell Painting assay. High-content images were acquired and analysed to generate phenotypic fingerprints, demonstrating how CellInsight-class systems support compound mode-of-action discovery in oncology.
Phenotypic profiling of small molecules using cell painting assay in HCT116 colorectal cancer cells
CellInsight CX7
Read the paper | DOI
2024 PLOS One methods paper presenting an integrated platform for automated high-content screening of 3D tumour spheroids at subcellular resolution. The workflow combines confocal imaging with automated image analysis, relevant to labs running 3D phenotypic screens on CellInsight CX7 LZR systems.
an automated high-content screening and assay platform for the analysis of spheroids at subcellular resolution
CellInsight CX7
Read the paper | DOI
2024 open-access study that fuses Cell Painting image data with compound structural information via a Swin transformer to predict kinase-inhibitor mechanism of action. It showcases the analytical depth of Cell Painting datasets generated on high-content platforms such as the CellInsight CX7.
Cell-vision fusion: a Swin transformer-based approach for predicting kinase inhibitor mechanism of action from Cell Painting data
CellInsight CX7
Read the paper | DOI
2025 Angewandte Chemie paper that uses image-based high-content screening with clickable chemical probes to discover inhibitors of the XPB helicase. The work illustrates how high-content platforms enable direct target-engagement readouts alongside morphological phenotyping in drug discovery.
Imaging-based high-content screening with clickable probes identifies XPB inhibitors
CellInsight CX7
Read the paper | DOI
2024 Journal of Experimental & Clinical Cancer Research study that screened FDA-approved drugs using high-content imaging to identify compounds that boost CAR T cell activity. The approach shows the value of high-content platforms in immuno-oncology target discovery and combination-therapy screening.
a high-content screen of FDA approved drugs to enhance CAR T cell function: ingenol-3-angelate improves B7-H3-CAR T cell activity by upregulating B7-H3 on the target cell surface via PKCα activation
CellInsight CX7
Read the paper | DOI
2024 Pharmaceutical Research paper applying high-content image analysis to map macrophage responses to a broad panel of drugs. The study demonstrates multi-parametric phenotyping of primary and cell-line macrophages, a typical CellInsight CX7 use case in drug safety and immunology.
High content image analysis of cellular responses of the murine J774A.1 cell line and primary human alveolar macrophages to an extended panel of pharmaceutical agents
CellInsight CX7
Read the paper | DOI
2024 Biological Imaging / Cambridge Core study showing that transferring Cell Painting phenotypic models between assays increases screening hit rates. The paper underlines how high-content platforms generate reusable morphological fingerprints that improve drug-discovery efficiency.
Cell painting transfer increases screening hit rate
CellInsight CX7
Read the paper | DOI
2026 Journal of Imaging methods paper on automated morphological profiling with deep-learning segmentation for high-throughput phenotypic screens. The work aligns directly with CellInsight CX7 workflows where automated segmentation and feature extraction are central to HCA output.
Automated morphological profiling via deep learning-based segmentation for high-throughput phenotypic screening
CellInsight CX7
Read the paper | DOI
2026 Research square — Cancer
A reversible broad-spectrum antiviral targets the human V-ATPase VO domain.
CellInsight CX7
Increasing threats of viral disease underscore the urgent need for broad-spectrum antiviral drugs (BSADs). Host proteins utilized by human pathogenic viruses are key BSAD targets. The vacuolar-type H+-ATPase (V-ATPase) has been identified as a proviral factor for most pH-dependent enveloped virus...
2026 Cancer cell international — Cancer
Single-cell transcriptomics uncovers heterogenous cell clusters and the biomarker FUT11 in ovarian cancer progression.
CellInsight CX7
BACKGROUND: Ovarian cancer (OC) is the most lethal of gynecological cancers and presents a poor prognosis due to difficulty in early diagnosis, extensive abdominal metastasis and chemo-resistance. We utilized single-cell transcriptomics to deconvolute intratumoral heterogeneity and identify bioma...
2026 Autophagy — Cancer
A role for CASM in the repair of damaged Golgi architecture.
CellInsight CX7
The term CASM describes a process in which MAP1LC3B/LC3B and other Atg8-family proteins are covalently ligated to lipids in damaged endomembranes. While CASM is commonly described as a cytoprotective response to multiple types of membrane damage, how CASM helps cells maintain homeostasis is still...
2026 PloS one — High-Content Screening
High-throughput high content quantification of HIV-1 viral infectious output.
CellInsight CX7
Infection with human immunodeficiency virus (HIV-1) remains a global health issue and still drives the development of significant pathology and various comorbidities. Antiretroviral therapy (ART) can effectively suppress viral replication but is often initiated months or years after initial infec...
2026 Emerging microbes & infections — High-Content Screening
TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection.
CellInsight CX7
Human TMPRSS2 is a type II transmembrane serine protease and an essential host factor for SARS-CoV-2 and influenza A virus (IAV H1N1) infections. It facilitates the cleavage of viral surface glycoproteins, which are required for membrane fusion. This importance makes it an attractive target for h...
2026 ACS omega — High-Content Screening
Drug-Induced Phospholipidosis as an Artifact in Antiviral Drug Repurposing.
CellInsight CX7
Drug repurposing, in principle, can speed antiviral drug discovery. Among the molecules most frequently advanced in such repurposing efforts is a group of structurally diverse cationic amphiphilic drugs (CADs). While CADs have shown micromolar to mid-nanomolar antiviral activity in cell-based ass...
2026 Research square — Infectious Disease & Neuroscience
BRD1 haploinsufficiency alters early neuronal programming and disrupts maturation in human induced glutamatergic neurons.
CellInsight CX7
BRD1 is an epigenetic regulator implicated in neurodevelopmental and psychiatric disorders, yet its role in human neuronal differentiation, maturation, and function remains poorly understood. Here we show that BRD1 haploinsufficiency disrupts early neuronal programming, resulting in accelerated m...
2026 JACC. Basic to translational science — Infectious Disease & Neuroscience
Abnormal Lipid Signaling Characterizes Diastolic Dysfunction in Pediatric Cardiomyopathy.
CellInsight CX7
Pediatric cardiomyopathy is a major cause of diastolic heart failure; yet, its mechanisms remain unclear. Global myocardial transcriptomic and blood lipidomic profiling revealed a distinct metabolic signature of diastolic dysfunction marked by dysregulated lipid signaling. A machine learning mode...
2026 Stem cell reports — Infectious Disease & Neuroscience
Comparative lipidomics of iPSC-derived microglia protocols reveal lipid droplet and immune differences mediated by media composition.
CellInsight CX7
Altered microglial lipid metabolism is heavily implicated in Alzheimer's disease (AD) and aging. Recently, protocols were developed to generate human induced pluripotent stem cell-derived microglia-like cells (iMGL) to study microglial function in vitro, including embryoid body-based methods and ...
Imaging technique: Live-cell / fluorescence microscopy
Long Non-Coding RNA Nuclear-Enriched Abundant Transcript 1 (NEAT1) Represses Proliferation of Trophoblast Cells in Rats with Preeclampsia via the MicroRNA-373/FLT1 Axis.
EVOS M5000
Cell type: Trophoblast cells
Imaging technique: Live-cell / brightfield imaging
Effect of microfluidic processing on the viability of boar and bull spermatozoa.
EVOS M5000
Cell type: Boar and bull spermatozoa
Imaging technique: Phenotypic brightfield/fluorescence imaging
Phenotypic and functional characterization of first-trimester human placental macrophages, Hofbauer cells.
EVOS M5000
Cell type: Placental macrophages (Hofbauer cells)
Imaging technique: Fluorescence microscopy
Engineering Intracellular Protein Sensors in Mammalian Cells.
EVOS M5000
Cell type: Mammalian cells (engineered protein sensors)
Imaging technique: Fluorescence/bioluminescence reporter imaging
R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling.
EVOS M5000
Cell type: Cultured cells (WNT signaling reporter)
Imaging technique: Fluorescence microscopy
SON and SRRM2 are essential for nuclear speckle formation.
EVOS M5000
Cell type: Cultured human cells
Imaging technique: fluorescence microscopy
JQKD82 Inhibits HIV Infection of Macrophages Through Blocking Viral Entry and Enhancing Antiviral ISG Responses.
EVOS M7000
Cell type: stem cells, macrophages
Imaging technique: live-cell imaging, confocal microscopy, brightfield microscopy
Spatially decoding genotype-associated epigenetic landscapes in human lymphoma FFPE tissues via epi-Patho-DBiT.
EVOS M7000
Cell type: HeLa cells, stem cells, macrophages, neurons, endothelial cells, epithelial cells
Imaging technique: confocal microscopy, brightfield microscopy
CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity.
EVOS M7000
Cell type: stem cells, macrophages, endothelial cells
Imaging technique: time-lapse microscopy
Imaging-Guided Live Single-Cell Lipid Profiling of Leader and Follower Cellsduring Collective Migration of Triple-Negative Breast Cancer Cells.
EVOS M7000
Cell type: macrophages
Imaging technique: fluorescence microscopy, confocal microscopy
Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor-Ligand Interactions.
EVOS M7000
Cell type: A549 lung cancer cells, stem cells, fibroblasts, epithelial cells
Imaging technique: confocal microscopy
Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma.
EVOS M7000
Cell type: cell lines
Imaging technique: fluorescence microscopy
NS2 of respiratory syncytial virus causes G2/M accumulation in HeLa/Fucci(CA)2 cells.
EVOS M7000
Cell type: HeLa cells, A549 lung cancer cells, hepatocytes, epithelial cells
Imaging technique: confocal microscopy
Effects of Common Food Additives Kappa-, Iota- and Lambda-Carrageenans on Intestinal Epithelial Cell Activation and Barrier Disruption.
EVOS M7000
Cell type: HeLa cells, fibroblasts, epithelial cells
Imaging technique: fluorescence microscopy
The CD49b (ITGA2) collagen receptor excludes CD8+ T cell infiltration in pancreatic ductal adenocarcinoma.
EVOS M7000
Cell type: HeLa cells, HEK293 cells, fibroblasts, macrophages, endothelial cells, epithelial cells
Imaging technique: confocal microscopy
3D-printed dictamni-calcium silicate scaffolds modulate the osteoimmune microenvironment and enhance macrophage-derived exosomal miR-21 signaling in vascularized bone regeneration.
EVOS M7000
Cell type: stem cells, fibroblasts, macrophages, neurons, keratinocytes, endothelial cells
Imaging technique: fluorescence microscopy, live-cell imaging, confocal microscopy
S100A9 modulates USP7-mediated stabilization of NCOA4 to promote ferroptosis in sepsis-associated acute lung injury.
EVOS M7000
Cell type: HeLa cells, HEK293 cells, macrophages, endothelial cells, epithelial cells
Imaging technique: fluorescence microscopy
Pomegranate peel extract alleviates diabetic retinopathy by suppressing the PI3K/AKT/HIF-1α/VEGF pathway and gut microbiota modulation.
EVOS M7000
Cell type: HeLa cells, HepG2 hepatoma cells, macrophages, endothelial cells, epithelial cells
Imaging technique: fluorescence microscopy
Patient-derived tumor organoids for personalized cancer immunotherapy: An immunopeptidome-to-validation approach in RCC and BC.
EVOS M7000
Cell type: stem cells, fibroblasts, macrophages, hepatocytes, epithelial cells
Imaging technique: fluorescence microscopy, brightfield microscopy, Z-stack imaging
Formulation Characteristics of Solid-Dispersible Self-Emulsifying Drug Delivery Systems for Dual Drug Delivery.
EVOS M7000
Cell type: cell lines
Imaging technique: fluorescence microscopy
Targeting Bruton tyrosine kinase with acalabrutinib attenuates murine sclerodermatous chronic graft versus host disease.
EVOS M7000
Cell type: stem cells, fibroblasts, macrophages, keratinocytes, epithelial cells
Imaging technique: brightfield microscopy
Preclinical Drug-Response Profiling Identifies BMI1 Inhibition as a Therapeutic Option for Hepatoblastoma.
EVOS M7000
Cell type: HEK293 cells, MCF-7 breast cancer cells, HepG2 hepatoma cells, stem cells, fibroblasts, keratinocytes, epithelial cells
Imaging technique: fluorescence microscopy
Small-Molecule Targeting of VDAC Disrupts Mitochondrial Bioenergetics and Suppresses Melanoma Cell Survival and Migration.
EVOS M7000
Cell type: cell lines
Imaging technique: live-cell imaging, time-lapse microscopy, confocal microscopy
RNA helicase DDX6 governs ASC speck formation in P-bodies and the transition to stress granules via phase separation during inflammasome activation.
EVOS M7000
Cell type: HEK293 cells, stem cells, macrophages, epithelial cells
Imaging technique: fluorescence microscopy
Genetic disruption of Capns1 impairs metastatic phenotypes in murine mammary carcinoma cells.
EVOS M7000
Cell type: HEK293 cells
Imaging technique: fluorescence microscopy
Feasibility of PIK3CA Mutation Detection via Microfluidic Isolation of Disseminated Tumor Cells from Bone Marrow in Breast Cancer Patients.
EVOS M7000
Cell type: MCF-7 breast cancer cells, stem cells
Imaging technique: confocal microscopy
IGF2BP2-driven serine metabolism promotes the progression of thyroid carcinoma via m6A-PHGDH.
EVOS M7000
Cell type: stem cells, macrophages
Imaging technique: fluorescence microscopy
Fasting requires Peroxiredoxin 2 and Peroxiredoxin 6 to coordinate redox dependent mitochondrial and lipid remodelling in Caenorhabditis elegans.
EVOS M7000
Cell type: neurons
Imaging technique: fluorescence microscopy
The pentose phosphate pathway contributes to excess lactate production in radiation-induced fibroblast to myofibroblast transdifferentiation.
EVOS M7000
Cell type: fibroblasts, macrophages, epithelial cells
Imaging technique: fluorescence microscopy
Target sequence-conditioned design of peptide binders using masked language modeling.
EVOS M7000
Cell type: HeLa cells, HEK293 cells, fibroblasts
Imaging technique: fluorescence microscopy
Comprehensive genomics and functional analyses identify SMARCAL1 as a key oncogenic regulator in lung adenocarcinoma.
EVOS M7000
Cell type: A549 lung cancer cells, macrophages, neurons
Imaging technique: confocal microscopy
Direct coupling and protective activation of DRP1 by the DNA-PKcs inhibitor KU-57788 synergizes with ferroptosis in anaplastic thyroid cancer cells.
EVOS M7000
Cell type: fibroblasts, macrophages
Imaging technique: fluorescence microscopy
CD8 immunoPET imaging to stratify response and guide combination immunotherapy and radiation in triple negative breast cancer.
EVOS M7000
Cell type: macrophages
Imaging technique: fluorescence microscopy
Senescent-associated β-galactosidase accumulation does not correlate with lifespan in different strains of Nothobranchius furzeri but does respond to intermittent fasting to extend lifespan.
EVOS M7000
Cell type: stem cells
Imaging technique: fluorescence microscopy
Novel African American Colorectal Cancer MSH3 Variants Associate With Major Genomic Instability.
EVOS M7000
Cell type: cell lines
Imaging technique: fluorescence microscopy
CpG 1018 augments mRNA vaccine-induced anti-tumor immunity by potentiating CD8+ T cell responses.
EVOS M7000
Cell type: stem cells, macrophages
Imaging technique: fluorescence microscopy
Effects of SRW® Stem on the functional properties, oxidative stress and inflammation of human umbilical cord mesenchymal stem cells.
EVOS M7000
Cell type: stem cells, fibroblasts, macrophages
Imaging technique: confocal microscopy, brightfield microscopy, Z-stack imaging
Polyamine homeostasis in Caenorhabditis elegans relies primarily on transport.
EVOS M7000
Cell type: stem cells, fibroblasts, neurons
Imaging technique: confocal microscopy
Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions.
EVOS M7000
Cell type: stem cells, fibroblasts, macrophages, endothelial cells, epithelial cells
Imaging technique: confocal microscopy
Importin α regulates ciliogenesis and cilia length with implications for Xenopus nephrogenesis.
EVOS M7000
Cell type: stem cells, epithelial cells
Imaging technique: confocal microscopy, brightfield microscopy
SiRNA-mediated knockdown of TOP2B protects hiPSC-derived cardiomyocytes from doxorubicin-induced toxicity.
EVOS M7000
Cell type: HeLa cells, stem cells, iPSCs, fibroblasts, neurons
Imaging technique: fluorescence microscopy, brightfield microscopy
Mechanistic models position ceritinib as a nuclear integrity disrupting therapy in pediatric liver tumors.
EVOS M7000
Cell type: HepG2 hepatoma cells, fibroblasts, keratinocytes, epithelial cells
Imaging technique: fluorescence microscopy
Bioactive factors in endometriosis peritoneal fluid remodel human cardiomyocytes.
EVOS M7000
Cell type: stem cells, iPSCs, fibroblasts, macrophages, endothelial cells
Imaging technique: fluorescence microscopy
Addition of lactic acid bacteria to diluted ram semen as vehicle for vaginal inoculation: interaction with seminal microbiota, sperm quality and antibacterial in vitro effect against Mycoplasma agalactiae.
EVOS M7000
Cell type: cell lines
Imaging technique: fluorescence microscopy
Authentic Phosphorylation of α-Synuclein at Ser129 Reveals Functional Differences Not Captured by the S129D Phosphomimetic.
EVOS M7000
Cell type: SH-SY5Y neuroblastoma cells, neurons
Imaging technique: fluorescence microscopy
Fabrication of High-Density Multimodal Neural Probes Based on Heterogeneously Integrated CMOS.
EVOS M7000
Cell type: neurons
Imaging technique: time-lapse microscopy, brightfield microscopy
Peering Inside the Black Box: Explainable AI to Interpret Advanced Computer Vision Fungal Pathogen Prediction.
EVOS M7000
Cell type: cell lines
Imaging technique: fluorescence microscopy, confocal microscopy
Universal conditional knockout approach to multiple species, from fish to human induced pluripotent stem cells.
EVOS M7000
Cell type: stem cells, iPSCs, neurons
Imaging technique: fluorescence microscopy
miR-181a post-transcriptionally targets GRK2 to limit maladaptive signaling in cardiomyocytes.
EVOS M7000
Cell type: fibroblasts, endothelial cells
Imaging technique: confocal microscopy
Fentanyl blockade of K+ channels contributes to wooden chest syndrome.
EVOS M7000
Cell type: HEK293 cells, neurons
Imaging technique: time-lapse microscopy, confocal microscopy
Photochemical nanomotors reverse anxiety- and depressive-related behaviors in rodents via spatiotemporal polarity dynamics tuning.
EVOS M7000
Cell type: iPSCs, neurons
Imaging technique: fluorescence microscopy
Retinoic acid inhibits the infection of porcine reproductive and respiratory syndrome virus.
EVOS M7000
Cell type: HEK293 cells, stem cells, macrophages, epithelial cells
Imaging technique: fluorescence microscopy, time-lapse microscopy, confocal microscopy, Z-stack imaging
Micropatterned DNA Hydrogels for Spatiotemporal Programming of Chemical Reaction Networks.
EVOS M7000
Cell type: stem cells, iPSCs
Imaging technique: confocal microscopy
Single-cell transcriptomic analyses reveal angiogenic vascular responses to chronic cerebral hypoperfusion.
EVOS M7000
Cell type: stem cells, fibroblasts, macrophages, neurons, endothelial cells, epithelial cells
Imaging technique: confocal microscopy, Z-stack imaging
Structural insights into functional regulation of the human CPEB3 prion by an amyloid-forming segment.
EVOS M7000
Cell type: HeLa cells, HEK293 cells, neurons
Imaging technique: fluorescence microscopy
Corneal Endothelium Regeneration with Decellularized Porcine Corneal Extracellular Matrix Scaffolds.
EVOS M7000
Cell type: stem cells, endothelial cells
Imaging technique: time-lapse microscopy, confocal microscopy, Z-stack imaging
Novel reporter constructs to accelerate antiviral and therapeutic discovery for Enterovirus-A71.
EVOS M7000
Cell type: HEK293 cells, stem cells, iPSCs, epithelial cells
Read W30 roundup →
W30 — EVOS M7000 Research Roundup
EVOS M7000CellInsight CX7
A fresh batch of M7000 papers across cancer, cell biology and infectious/neuroscience, with Google Scholar, PubMed/PMC and DOI links.
Read W30 roundup →
W30 — CellInsight CX7 Research Roundup
EVOS M7000CellInsight CX7
A curated batch of CellInsight CX7 papers across cancer, high-content screening and infectious/neuroscience, with Google Scholar, PubMed/PMC and DOI links.
Read W29 roundup →
W29 — EVOS M5000 Research Roundup
EVOS M7000CellInsight CX7
Independent M5000 papers tagged by disease area, cell type and imaging technique, with Google Scholar, PubMed/PMC and DOI links.
Read W28 roundup →
W28 — EVOS S1000 Research Roundup
EVOS M7000CellInsight CX7
A batch of EVOS S1000 Gen 2 colour camera papers with Google Scholar and DOI links.
System: EVOS M7000 — Papers: 25
EVOS M7000 in Cell Biology Research
EVOS M7000CellInsight CX7
Cell-biology assays across cell lines, stem cells, organoids, and primary cultures using brightfield and fluorescence imaging.
System: EVOS M7000 — Papers: 36
EVOS M7000 in Cancer Research
EVOS M7000CellInsight CX7
Oncology studies covering proliferation, migration, invasion, cytotoxicity, and reporter-based readouts.
System: EVOS M7000 — Papers: 15
EVOS M7000 in Infectious Disease and Neuroscience Research
EVOS M7000CellInsight CX7
Virology, bacteriology, COVID-19, and neurodegeneration assays using live-cell and endpoint imaging.
System: CellInsight CX7 — Papers: 25
CellInsight CX7 in High-Content Imaging
EVOS M7000CellInsight CX7
High-content screening across multi-well plates for phenotypic cell-biology assays.
System: CellInsight CX7 — Papers: 38
CellInsight CX7 in Cancer Research
EVOS M7000CellInsight CX7
Oncology drug-discovery and mechanism-of-action studies using multi-parameter high-content imaging.
System: CellInsight CX7 — Papers: 18
CellInsight CX7 in Infectious Disease and Neuroscience Research
EVOS M7000CellInsight CX7
Infection models and iPSC-derived neuronal phenotypes for virology, immunology, and neurobiology.
Imaging technique: fluorescence microscopy, high-content imaging, confocal microscopy
IRX3 depletion promotes early cardiac commitment of hiPSC-Derived Cardiomyocytes.
EVOS M7000
Cell type: stem cells, iPSCs, fibroblasts
Imaging technique: confocal microscopy, brightfield microscopy, Z-stack imaging
Recapitulating apicobasal tissue polarity in extracellular matrix-incorporated airway organoids.
EVOS M7000
Cell type: stem cells, iPSCs, fibroblasts, epithelial cells
Imaging technique: live-cell imaging
Regulation of tension-dependent localization of LATS1 and LATS2 to adherens junctions.
EVOS M7000
Cell type: HEK293 cells, stem cells, epithelial cells
Imaging technique: fluorescence microscopy, confocal microscopy
Surface colonization of Aureobasidium pullulans: a multimodal microscopy study toward living coating development.
EVOS M7000
Cell type: endothelial cells
Imaging technique: fluorescence microscopy
Collagen hybridizing peptide imaging and delivery of therapeutic antibody in rheumatoid arthritis models.
EVOS M7000
Cell type: fibroblasts, macrophages, endothelial cells
Imaging technique: fluorescence microscopy
VSIG10L is a major determinant of esophageal homeostasis and inherited predisposition to Barrett's esophagus.
EVOS M7000
Cell type: HeLa cells, stem cells, fibroblasts, keratinocytes, epithelial cells
Imaging technique: confocal microscopy
Polydopamine-Coated Surfaces Promote Adhesion, Migration, Proliferation, Chemoresistance, Stemness, and Epithelial-Mesenchymal Transition of Human Prostate Cancer Cell Lines In Vitro via Integrin α2β1-FAK-JNK Signaling.
EVOS M7000
Cell type: stem cells, fibroblasts, macrophages, keratinocytes, endothelial cells, epithelial cells
Imaging technique: time-lapse microscopy, confocal microscopy
Acacetin Attenuates Lysophosphatidylcholine-Induced Vascular Smooth Muscle Cell Injury via Sirt1-Nrf2/p62 Signaling Axis.
EVOS M7000
Cell type: A549 lung cancer cells, fibroblasts, macrophages, endothelial cells
Imaging technique: high-content imaging, brightfield microscopy, Z-stack imaging
Transcranial microtesla magnetic fields suppress neuroinflammation and neuronal oxidative stress burden.
EVOS M7000
Cell type: SH-SY5Y neuroblastoma cells, iPSCs, macrophages, neurons, endothelial cells
Imaging technique: fluorescence microscopy, confocal microscopy, Z-stack imaging
Apical-out airway organoids as a pathophysiological model to study macrophage-mediated epithelial responses to microplastics.
EVOS M7000
Cell type: stem cells, macrophages, epithelial cells
Imaging technique: fluorescence microscopy
The Preclinical Effects and Mechanisms of Biofield Therapy on Pancreatic Cancer Cell Growth and Metastasis.
EVOS M7000
Cell type: HEK293 cells, stem cells, macrophages, keratinocytes, hepatocytes, epithelial cells
Imaging technique: fluorescence microscopy
AhR agonist Ficz modulates T follicular helper cells and ameliorates skin fibrosis in a bleomycin-induced SSc mouse model.
EVOS M7000
Cell type: fibroblasts
Imaging technique: fluorescence microscopy
Remote stimulation of mitochondria and the antioxidant potential of thymocytes by weak non-ionizing non-thermal broadband pulsed electromagnetic fields in mouse.
EVOS M7000
Cell type: fibroblasts, macrophages
Imaging technique: fluorescence microscopy
5-methoxyresorcinol mitigates postmenopausal osteoporosis through regulation of the PI3K-AKT-GSK3β signaling pathway and ROS homeostasis.
EVOS M7000
Cell type: fibroblasts, macrophages
Imaging technique: confocal microscopy, Z-stack imaging
Tentonin 3 regulates the proliferation and migration of neural stem cells during embryonic brain development.
EVOS M7000
Cell type: HEK293 cells, stem cells, neurons, epithelial cells
Imaging technique: fluorescence microscopy
An automated and high-throughput approach for enhanced precision of adenoviral titering.
EVOS M7000
Cell type: HEK293 cells, A549 lung cancer cells, primary cells, macrophages, neurons
Imaging technique: fluorescence microscopy
HDGF Protects Retinal Pigment Epithelium from Glyoxal-Induced Ferroptosis via SIRT1/PGC-1α/Nrf2 Pathway.
EVOS M7000
Cell type: primary cells, neurons, epithelial cells
Imaging technique: live-cell imaging, time-lapse microscopy, brightfield microscopy
Quantification of timelapse 3D tumor spheroid killing activity of NK cells using a live-cell imaging system.
EVOS M7000
Cell type: HeLa cells, A549 lung cancer cells, stem cells, iPSCs
Imaging technique: fluorescence microscopy, time-lapse microscopy
Oxygen-Releasing Nanodroplets Relieve Intratumoral Hypoxia and Potentiate Photodynamic Therapy in 3D Head and Neck Cancer Spheroids.
EVOS M7000
Cell type: stem cells
Imaging technique: fluorescence microscopy, confocal microscopy
Cationic Peptoids for Systemic In Vivo Cartilage-Targeting.
EVOS M7000
Cell type: endothelial cells
Imaging technique: fluorescence microscopy
Anti-pyocyanin Antibody Exhibits Cytotoxicity Protective Effects on Macrophages: A Promising Innovative Therapeutic Approach for Pseudomonas aeruginosa Infections.
EVOS M7000
Cell type: A549 lung cancer cells, HepG2 hepatoma cells, fibroblasts, macrophages, epithelial cells
Imaging technique: fluorescence microscopy
The de novo DNA methyltransferase 3B is a novel epigenetic regulator of MYC in multiple myeloma, representing a promising therapeutic target to counter relapse.
EVOS M7000
Cell type: stem cells
Imaging technique: fluorescence microscopy
Establishment of chicken muscle and adipogenic cell cultures for cultivated meat production.
EVOS M7000
Cell type: HeLa cells, primary cells, stem cells, iPSCs, fibroblasts
Imaging technique: fluorescence microscopy
Facilitating microplastic ingestion in aquatic models: A verified protocol for daphnia magna as a trojan horse vector.
EVOS M7000
Cell type: cell lines
Imaging technique: confocal microscopy
A New Methodology for the Quantification of Neutrophil Extracellular Traps in Patient Plasma.
EVOS M7000
Cell type: cell lines
Imaging technique: Fluorescence/confocal imaging
Negative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain.
EVOS M5000
Cell type: Immune cells (B cells/macrophages)
Imaging technique: Fluorescence microscopy / histopathology
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
EVOS M5000
Cell type: Airway epithelial / lung cells
Imaging technique: Fluorescence/histopathology imaging
Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2.
EVOS M5000
Cell type: Respiratory epithelial / lung cells (hACE2 transgenic mice)
Imaging technique: Photothermal / fluorescence imaging
Photothermal-Induced Antibacterial Activity of Gold Nanorods Loaded into Polymeric Hydrogel against Pseudomonas aeruginosa Biofilm.
EVOS M5000
Cell type: Bacteria (Pseudomonas aeruginosa)
Imaging technique: Fluorescence microscopy
Porcine circovirus type 2 promotes Actinobacillus pleuropneumoniae survival during coinfection of porcine alveolar macrophages by inhibiting ROS production.
EVOS M5000
Cell type: Porcine alveolar macrophages
Imaging technique: Fluorescence microscopy
Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity.
EVOS M5000
Cell type: Plasmodium falciparum / red blood cells
Imaging technique: Fluorescence microscopy / optical sensing
A portable and high-sensitivity optical sensing system for detecting fluorescently labeled enterohaemorrhagic Escherichia coli Shiga toxin 2B-subunit.
EVOS M5000
Cell type: E. coli / bacterial cells
Imaging technique: Fluorescence/histology imaging
Acute SARS-CoV-2 Infection is Highly Cytopathic, Elicits a Robust Innate Immune Response and is Efficiently Prevented by EIDD-2801.
EVOS M5000
Cell type: Lung epithelial / immune cells
Background: Metastatic melanoma is a highly aggressive malignancy with poor prognoses and frequent resistance to conventional chemotherapy. Approximately 40% of melanoma cases carry the BRAFV600E mutation, for which vemurafenib, a selective BRAFV600E inhibitor, is approved. Despite initial clinical benefits, vemurafenib often leads to drug resistance and relapse, highlighting t
Design, Synthesis, and Bioactivity Assessment of Modified Vemurafenib Analog.
EVOS M5000
Cell type: T cell | Technique: Fluorescence imaging | Disease/area: Melanoma
EVOS M5000 microscope ( F ) and quantified based on the extracted dye using a plate reader ( G ). p value denotes ANOVA with Bonferroni's multiple comparisons test. Scale bar, 300 μm
Lipid transfer proteins and PI4KIIα initiate nuclear p53-phosphoinositide signaling.
EVOS M5000
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Cancer
Ferroptosis is a programmed form of cell death in which iron-dependent lipid peroxidation is the main feature. Macrophages are the major cells of the immune system, they function in a pro-oxidative environment, so the study of their susceptibility to ferroptosis and the search for approaches to its regulation are important. The aim of the study was to investigate ferroptosis in
Regulation of Ferroptosis in Human Macrophage by Nitric Oxide Donors.
EVOS M5000
Cell type: Macrophage | Technique: Fluorescence imaging | Disease/area: Leukemia
BACKGROUND: Atypical teratoid/rhabdoid tumors (AT/RT) are aggressive pediatric CNS malignancies characterized by SMARCB1 loss, which leads to the dysregulated expression of Enhancer of Zeste Homolog 2 (EZH2), a key catalytic component of the Polycomb Repressive Complex 2 (PRC2). This dysregulation results in aberrant trimethylation of histone H3 at lysine 27 (H3K27me3), driving
The MALAT1-EZH2 axis regulates PRC2 activity and promotes the mesenchymal phenotype in pediatric atypical teratoid/rhabdoid tumors.
EVOS M5000
Cell type: T cell | Technique: Fluorescence imaging | Disease/area: Cancer
There is a tremendous upsurge in lung cancer incidences due to changing lifestyles and other environmental risk factors. Unfortunately, the use of clinical therapeutics is causing serious side effects and drug-resistant tumors. Taking account of the severity of lung cancer malignancy and the pressing need for natural therapeutics, we investigated the anticancer potential of bix
Deciphering the effects of bixin on pulmonary alveolar adenocarcinoma migration and proliferation via targeting BAX/BCL-2 and Cyclin D1.
EVOS M5000
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Lung cancer
Breast cancer is a widespread and aggressive disease, with 2.3 million new cases globally in 2022. Metastasis, the spread of cancer cells to distant organs, remains a leading cause of breast cancer-related mortality. Current treatment options, particularly traditional chemotherapeutic drugs, are often associated with severe side effects, emphasizing the urgent need for safer an
Unraveling the therapeutic potential of Elaeagnus angustifolia extract on triple-negative breast cancer (TNBC): An investigation using zebrafish model.
EVOS M5000
Cell type: Cancer cell | Technique: Fluorescence imaging | Disease/area: Breast cancer
Chemodynamic therapy (CDT), which utilizes the catalytic reactions of nanoparticles to inhibit tumor growth, is a promising approach in cancer therapy. However, its efficacy is limited by insufficient hydrogen peroxide (H2O2) concentration in tumor microenvironments and unsatisfactory enzymatic catalytic activity. To overcome these limitations, ultra-small iron-based (USIB) nan
Ultra-Small Iron-Based Nanoparticles with Mild Photothermal-Enhanced Cascade Enzyme-Mimic Reactions for Tumor Therapy.
EVOS M5000
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Cancer
BACKGROUND: Gastric cancer is the fifth leading cause of cancer-related deaths worldwide. Apatinib is a third-line treatment for gastric cancer. However, the development of resistance significantly limits its efficacy, and effective and safe strategies to overcome Apatinib resistance remain elusive. RESULTS: We found that Apatinib-resistant gastric cancer cells (MGC803/AR and A
Cholesterol confers resistance to Apatinib-mediated ferroptosis in gastric cancer.
EVOS M5000
Cell type: Cancer cell | Technique: Fluorescence imaging | Disease/area: Cancer
Acute extremity compartment syndrome (AECS) is a severe surgical emergency with no effective non-invasive therapies available. Here, we demonstrate that low-intensity pulsed ultrasound (LIPUS) attenuates muscle damage by suppressing oxidative stress and ferroptosis. In skeletal muscle cells following hypoxia-reoxygenation (H/R), LIPUS reduced reactive oxygen species (ROS), malo
Low-intensity pulsed ultrasound mitigates acute extremity compartment syndrome by mediating ferroptosis suppression.
EVOS M5000
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Cancer
Transcription factors that control stem cell programs are central drivers of cancer progression, metastasis, and therapy resistance. ARID3B, a DNA-binding protein overexpressed across multiple tumor types, expands the cancer stem cell population by regulating these pathways. Yet, how ARID3B is regulated remains largely unknown. Here, we uncover phosphorylation at Serine 89 as a
Serine 89 Phosphorylation Controls Nuclear Localization and Transcriptional Activity of ARID3B.
EVOS M5000
Cell type: Stem cell | Technique: Fluorescence imaging | Disease/area: Ovarian cancer
Three-dimensional (3D) culture systems that recapitulate the tumor microenvironment are essential for studying cancer cell behavior, drug response, and cell-matrix interactions. Here, we present a detailed protocol for generating 3D spheroid cultures from murine breast cancer cells using methacrylated gelatin (GelMA)-based bioink and a CELLINK BioX bioprinter. This method enabl
An Open-Source Automated Pipeline for Quantitative Morphological Analysis of 3D-Bioprinted Cancer Cell Spheroids.
EVOS M5000
Cell type: Cancer cell | Technique: Fluorescence imaging | Disease/area: Breast cancer
Glioma is one of the most common and aggressive types of brain tumors, characterized by generally low survival rates. Circular RNAs (circRNAs) have been identified as key players in the development of glioma. Our study aims to investigate the effect of circNRIP1 on glioma progression and elucidate the underlying mechanisms involved. The mRNA expression of circNRIP1, miR-106a-5p
Circular RNA circNRIP1 promotes glioma progression by regulating the miR-106a-5p/GPR133 pathway.
EVOS M5000
Cell type: Epithelial | Technique: Fluorescence imaging | Disease/area: Glioma
EVOS M5000 imaging system (Thermo Fisher Scientific) in the transmitted light channel are shown. Scale bar, 100 μm. n = 3 biological replicates (right). (C) Growth curve showing the rise in the percentage of AM
DLK1 is a GATA1s-driven dependency and therapeutic target in Down syndrome-associated myeloid leukemia.
EVOS M5000
Cell type: Biological samples | Technique: Fluorescence imaging | Disease/area: Leukemia
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but are associated with a range of immune-related adverse events, including neurological complications. We report the case of a 64-year-old man diagnosed with small-cell lung cancer who developed AMPA2 antibody-positive autoimmune encephalitis after receiving tislelizumab combined with chemotherapy. The pa
Immune checkpoint inhibitor-induced AMPA2 antibody-positive encephalitis: a case report.
EVOS M5000
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Lung cancer
EVOS M5000 imaging system (Invitrogen). The antibodies and the experiment conditions are listed in Supplementary Table 1.
Cannabidiol potentiates p53-driven autophagic cell death in non-small cell lung cancer following DNA damage: a novel synergistic approach beyond canonical pathways.
EVOS M5000
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Lung cancer
Graphene and its related nanocomposites have garnered significant interest due to their distinct physiochemical and biological properties. In this study, reduced graphene oxide-silver hybrid nanostructures were synthesized for applications in biomedical nanotechnology, particularly in targeting cancer stem cells (CSCs). A range of analytical techniques, such as X-ray diffractio
Composites of Reduced Graphene Oxide Based on Silver Nanoparticles and Their Effect on Breast Cancer Stem Cells.
EVOS M5000
Cell type: Cancer cell | Technique: Fluorescence imaging | Disease/area: Breast cancer
As stem cell therapy in regenerative medicine becomes more socially accepted, human perinatal tissue is attracting attention as a source because it can be harvested non-invasively. Human placental extracts (HPEs), which are prepared using acid hydrolysis and autoclaving, have been approved for treating menopausal disorders and liver dysfunction. This study investigated a new HP
Protective Effects of a New Human Placental Extract Against Hair Graying and Chemotherapy-Induced Peripheral Neuropathy.
EVOS M5000
Cell type: Neuron | Technique: Fluorescence imaging | Disease/area: Liver cancer
Organic and synthetic chemistry plays a crucial role in drug discovery fields. Moreover, chemical modifications of available molecules to enhance their efficacy, selectivity and safety have been considered as an attractive approach for the development of new bioactive agents. Indoles, a versatile group of natural heterocyclic compounds, have been widely used in pharmaceutical i
Amoebicidal effect of synthetic indoles against Acanthamoeba spp.: a study of cell death.
EVOS M5000
Cell type: Parasite | Technique: Fluorescence imaging | Disease/area: Cancer
The presence of aberrant double-stranded DNA (dsDNA) in the cytoplasm of cells is sensed by unique pattern recognition receptors (PRRs) to trigger innate immune response. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is activated by the presence of non-self or mislocalized self-dsDNA from nucleus or mitochondria released in response
Cytosolic Immunostimulatory DNA Ligands and DNA Damage Activate the Integrated Stress Response, Stress Granule Formation, and Cytokine Production.
EVOS M5000
Cell type: T cell | Technique: Fluorescence imaging | Disease/area: Cancer
Fibrolamellar carcinoma (FLC) is a type of primary liver cancer that predominantly affects healthy adolescents and young adults in a background of normal liver. The DNAJB1-PRKACA fusion gene is an oncogenic driver in FLC tumors. To investigate the oncogenic mechanisms of this fusion gene, we developed a model using human liver progenitor organoids engineered to express DNAJB1-P
Expression of DNAJB1-PRKACA oncogene suppresses the differentiation potential of liver progenitor organoids towards a hepatocyte lineage.
EVOS M5000
Cell type: Epithelial | Technique: Fluorescence imaging | Disease/area: Liver cancer
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a poor prognosis, partly due to cancer stem cells (CSCs) that drive progression and treatment resistance. We explored the therapeutic potential of inducing cuproptosis, a copper-dependent, regulated cell death, in CSC-enriched PDAC models. Using human and murine PDAC models, we evaluated elesclomol, a copper t
Elesclomol-copper combination synergistically targets mitochondrial metabolism in cancer stem cells to overcome chemoresistance in PDAC.
EVOS M5000
Cell type: Stem cell | Technique: Fluorescence imaging | Disease/area: Pancreatic cancer
Chronic hepatitis B virus (HBV) is a leading cause of liver disease and hepatocellular carcinoma that persists as a DNA mini-chromosome and replicates via genomic RNA intermediates. While HBV replication has been extensively studied, mechanisms governing viral RNA degradation remain unclear. Here, we identify a key role for the 5'-3' exoribonuclease XRN1 in regulating the HBV t
A key role for the exoribonuclease XRN1 in regulating the hepatitis B viral transcriptome.
EVOS M5000
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Liver cancer
Lung adenocarcinoma (LUAD), the most prevalent histological subtype of lung cancer, remains a leading cause of cancer-related mortality due to late diagnosis, metastasis, and therapy resistance. The aim of the study is to investigate the role of Kinetochore Scaffold 1 (KNL1) in promoting LUAD progression and its underlying molecular regulatory mechanisms.
KNL1 Regulates Ferroptosis Resistance and Migration in Lung Adenocarcinoma Cells via AMPK-mTOR Signaling.
EVOS M5000
Cell type: Cell culture models | Technique: Fluorescence imaging | Disease/area: Lung cancer
The TGF-β signaling pathway has both tumor-suppressive and metastasis-promoting effects in cancer, yet the molecular determinants governing this switch remain unclear. Here, we investigated the miR-16-1-3p/MDM2/p53 axis as a potential regulator of TGF-β/Smad signaling output in osteosarcoma. miR-16-1-3p overexpression alone markedly reduced the proliferative and clonogenic pote
The miR-16-1-3p suppresses proliferation and invasiveness via the MDM2-p53 axis in TGF-β1 signaling in osteosarcoma.
EVOS M5000
Cell type: Epithelial | Technique: Fluorescence imaging | Disease/area: Cancer
Cancer-related deaths primarily occur due to metastasis, a process involving the migration and invasion of cancer cells. In most solid tumors, metastasis occurs through collective cell migration (CCM), guided by "cellular leaders". These leader cells generate forces through actomyosin-mediated protrusion and contractility. The cytoskeletal mechanisms employed by metastatic cell
Navigating the Collective: Nanoparticle-Assisted Identification of Leader Cancer Cells During Migration.
EVOS M5000
Cell type: Cancer cell | Technique: Fluorescence imaging | Disease/area: Breast cancer
2026 Journal of medical virology — Cancer
JQKD82 Inhibits HIV Infection of Macrophages Through Blocking Viral Entry and Enhancing Antiviral ISG Responses.
EVOS M7000
JQKD82 is an epigenetic modulator that inhibits lysine-specific demethylase 5 (KDM5), a host factor implicated in HIV latency and cell survival. Although JQKD82 has been studied in latent HIV infection of T cell models, its effects on HIV infection in macrophages remain unclear. Here, we investig...
2026 Nature communications — Cancer
Spatially decoding genotype-associated epigenetic landscapes in human lymphoma FFPE tissues via epi-Patho-DBiT.
EVOS M7000
While formalin-fixed paraffin-embedded (FFPE) samples are invaluable for human non-Hodgkin B-cell lymphoma translational research, effective methods for spatial profiling of chromatin accessibility and histone modifications in these tissues remain limited. Here, we introduce epi-Patho-DBiT, a pla...
2026 Advanced science (Weinheim, Baden-Wurttemberg, Germany) — Cancer
CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity.
EVOS M7000
The surface protein CD177 on human neutrophil granulocytes is linked to tissue infiltration. In most individuals, circulating neutrophils comprise distinct fractions of CD177-expressing (CD177+) and non-expressing (CD177-) cells, which differ functionally and influence disease outcomes. Currently...
2026 PloS one — Cell Biology
IRX3 depletion promotes early cardiac commitment of hiPSC-Derived Cardiomyocytes.
EVOS M7000
Generating mature human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) remains a major obstacle to accurate disease modeling and cardiac repair. As the transcription factor Irx3 is a key determinant of ventricular conduction system fate in mice, we hypothesized that suppressing ...
2026 Biomaterials — Cell Biology
Recapitulating apicobasal tissue polarity in extracellular matrix-incorporated airway organoids.
EVOS M7000
The airway epithelium is a dynamic barrier that interfaces with the external environment and internal matrix along its apicobasal axis. To recapitulate this spatial organization and associated cell-ECM interactions in an organoid format, we present the decellularized extracellular matrix-incorpor...
2026 PloS one — Cell Biology
Regulation of tension-dependent localization of LATS1 and LATS2 to adherens junctions.
EVOS M7000
The LIM domain protein LIMD1 is a critical regulator of the Hippo signaling pathway, acting to sequester the kinases LATS1/2 to adherens junctions (AJs) in response to mechanical strain. Here, we identify the molecular basis for LIMD1 binding and recruitment of LATS1/2 to AJs. We show that while ...
2026 American journal of physiology. Heart and circulatory physiology — Infectious Disease & Neuroscience
Bioactive factors in endometriosis peritoneal fluid remodel human cardiomyocytes.
EVOS M7000
Endometriosis is associated with increased cardiovascular disease (CVD) risk, yet the cellular basis for this relationship remains unclear. We examined whether peritoneal fluid (PF) from women with endometriosis alters cardiomyocyte behavior in vitro. Human-induced pluripotent stem cell-derived c...
2026 BMC veterinary research — Infectious Disease & Neuroscience
Addition of lactic acid bacteria to diluted ram semen as vehicle for vaginal inoculation: interaction with seminal microbiota, sperm quality and antibacterial in vitro effect against Mycoplasma agalactiae.
EVOS M7000
BACKGROUND: The use of lactic acid bacteria (LAB) as a probiotic in seminal doses of small ruminants has been suggested due to its antibacterial effects against pathogens such as Mycoplasma agalactiae (Ma) and positive effects on ovine vaginal health. The present in vitro study evaluates the anti...
2026 ACS chemical biology — Infectious Disease & Neuroscience
Authentic Phosphorylation of α-Synuclein at Ser129 Reveals Functional Differences Not Captured by the S129D Phosphomimetic.
EVOS M7000
Phosphorylation at serine 129 (pS129) is a dominant post-translational modification of α-synuclein (αSyn) and a widely used pathological marker in Parkinson's disease, yet its mechanistic consequences remain debated across physiological and pathological contexts. Most studies rely on phosphomimet...
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