Curated literature review of independent peer-reviewed studies that used the EVOS M5000 Imaging System. Each paper is summarised by cell type, imaging technique, and disease area, with links to Google Scholar, PubMed, PMC and DOI where available. Plankton & Zoom does not host paywalled content.
Skin biology and fibroblast behaviour are common use-cases for the EVOS M5000, from aged dermal fibroblast cultures to atopic dermatitis models and implant-stoma fibroblast responses. The studies below are independent of the manufacturer’s citation list. These papers were identified by searching the open-access literature and verifying that the full text explicitly mentions the EVOS M5000 Imaging System as a microscope; they are not part of the manufacturer’s curated citation list.
Cell type: Skin cells / keratinocytes / fibroblasts
Imaging technique: Brightfield/phase-contrast optical microscopy
Disease area: Atopic dermatitis / skin inflammation
Mediators InflammPMC13347627
Cell type: Aged dermal fibroblasts (mouse primary)
Imaging technique: Live-cell / brightfield imaging
Disease area: Aging / impaired wound healing
Aged dermal fibroblasts exhibit reduced migration, proliferation, and extracellular matrix (ECM) production, alongside upregulation of pro-inflammatory signaling that disrupts the proliferative, granulation, and remodeling phases of wound healing. Despite these age-related impairments, tissue engineering biomaterials a...
Cells Tissues OrgansPMID 42319880 — PMC13317481
Google Scholar | PubMed | PMC | DOI
Cell type: Intestinal fibroblasts (human gut-on-a-chip)
Imaging technique: Microengineered 3D gut-on-chip imaging
Disease area: Intestinal fibrosis / Crohn-like remodeling
Biomechanical cues such as fluid shear stress and mechanical strain regulate intestinal physiology, yet their roles in shaping fibroblast fate during early fibrotic remodeling remain poorly defined. Here, we use a microengineered human gut-on-a-chip model that enables independent control of shear stress and mechanical ...
Adv Sci (Weinh)PMID 41961487 — PMC13317784
Google Scholar | PubMed | PMC | DOI
Cell type: Human skin explants / keratinocytes
Imaging technique: Ex vivo histology / fluorescence imaging
Disease area: Atopic dermatitis / S. aureus skin dysbiosis
Maintaining a balanced skin microbiota is essential for preserving epidermal barrier integrity and overall skin health. Dysbiosis, particularly the opportunistic overgrowth of Staphylococcus aureus, is associated with barrier dysfunction and inflammatory dermatoses such as atopic dermatitis, psoriasis, and acne. In dys...
MicroorganismsPMID 42354869 — PMC13304451
Google Scholar | PubMed | PMC | DOI
Cell type: Human fibroblasts
Imaging technique: Brightfield/fluorescence imaging
Disease area: Implant / stoma / fibroblast response
A soft-anchored titanium (Ti-6Al-4V) mesh implantable device was designed and morphologically characterised in an in vitro study. The mesh implant consists of a titanium mesh aimed at preserving continence and improving the quality of life for patients with a stoma. Titanium alloys are widely used in implantable device...
Sci RepPMID 42230665 — PMC13230510
Google Scholar | PubMed | PMC | DOI
Wound healing: a paradigm of regeneration. Annual Review of Cell and Developmental Biology 28:245–262. doi:10.1146/annurev-cellbio-101011-155931
View on DOIRegenerative medicine for wound healing: materials and therapies. Advanced Drug Delivery Reviews 84:1–2. doi:10.1016/j.addr.2015.02.006
View on DOIA scratch assay wounds a cell monolayer and images closure over time to measure migration.