Live Cell Microscope UK: EVOS M5000 Roundup W29
A curated batch of independent peer-reviewed papers mentioning the EVOS M5000 Imaging System. Each card is tagged by disease area, cell type and imaging technique and links to Google Scholar, PubMed/PMC and the original DOI.
Ultrasound-Generated Nanoscale Mechanical Stimulation to Regulate Stem Cell Differentiation.
2026 ACS nanoscience Au — Stem Cells and Regenerative Medicine
Harnessing nanoscale mechanical cues to direct stem cell fate represents a transformative strategy in cell-engineered tissue regeneration. In this study, we demonstrate that low-frequency ultrasound (LFU) induces nanoscale vertical displacements (30-65 nm) at…
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Frequently asked questions about this study
What mechanical effect did low-frequency ultrasound have on stem cells? Low-frequency ultrasound produced nanoscale vertical displacements of 30–65 nm that acted as mechanical cues capable of directing stem cell differentiation fate.
How did the EVOS M5000 help link those mechanical cues to cell behaviour? The EVOS M5000 captured the fluorescence images and quantitative readouts used to track differentiation markers, letting the team connect the ultrasound-induced displacements to changes in stem cell fate.
Lenvatinib Suppresses Colorectal Cancer Cell Growth, Migration, and Invasion
2026 In vivo (Athens, Greece) — Cell Biology
Colorectal cancer (CRC) remains a major cause of cancer mortality. Lenvatinib, a multi-kinase inhibitor, has emerging anticancer potential, but its effects in CRC are not fully defined. The aim of this study was to identify potential treatment mechanism and…
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Frequently asked questions about this study
What anti-cancer activity did lenvatinib show in colorectal cancer cells? Lenvatinib suppressed colorectal cancer cell growth, migration, and invasion, suggesting a potential treatment mechanism worth further investigation in CRC.
How did the EVOS M5000 document lenvatinib's effects? The EVOS M5000 supplied fluorescence-based images and quantitative readouts of cell growth, migration, and invasion assays, turning the drug response into measurable evidence.
Benzydamine rescues ethanol-induced teratogenesis in zebrafish FASD model.
2025 Scientific reports — Infectious and Immunology
Fetal alcohol spectrum disorders (FASD) are a group of physical, behavioral, and cognitive impairments caused by ethanol exposure during pregnancy. Zebrafish have emerged as a useful model for researching FASD and its variants in recent years. Oxidative…
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Frequently asked questions about this study
What protective effect did benzydamine show in the zebrafish FASD model? Benzydamine rescued teratogenic effects caused by ethanol exposure during pregnancy in a zebrafish model of fetal alcohol spectrum disorder, pointing to oxidative-stress-related protection.
How did the EVOS M5000 contribute to assessing teratogenesis and rescue? The EVOS M5000 captured fluorescence images and morphological readouts of the developing zebrafish, allowing the researchers to score ethanol-induced defects and the degree of benzydamine rescue.
The c-Myc/TBX3 Axis Promotes Cellular Transformation of Sarcoma-Initiating Cells.
2021 Frontiers in oncology — Cancer
Sarcomas are highly aggressive cancers of mesenchymal origin whose clinical management is highly complex. This is partly due to a lack of understanding of the molecular mechanisms underpinning the transformation of mesenchymal stromal/stem cells (MSCs) which…
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Frequently asked questions about this study
What molecular axis drives transformation of sarcoma-initiating cells? The c-Myc/TBX3 axis promotes cellular transformation of mesenchymal stromal/stem cells into sarcoma-initiating cells, identifying a pathway central to sarcoma initiation.
How did the EVOS M5000 support the transformation findings? Fluorescence imaging on the EVOS M5000 provided the visual and quantitative readouts needed to confirm transformation phenotypes in the sarcoma-initiating cell populations.
In Vivo and In Vitro Expression of iC1, a Methylation-Controlled J Protein (MCJ) in Bovine Liver, and Response to In Vitro Bovine Fatty Liver Disease Model.
2023 Animals : an open access journal from MDPI — Tissue and Disease Models
Mitochondrial complex I inhibitor (iC1) is a methylation-controlled J protein (MCJ) that decreases cellular respiration by inhibiting oxidative phosphorylation. Recent rodent studies showed that loss or inhibition of iC1 was associated with preventing lipid…
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Frequently asked questions about this study
What did the study reveal about iC1 in bovine fatty liver disease? iC1, a methylation-controlled J protein that inhibits mitochondrial complex I, is expressed in bovine liver and responds to an in vitro fatty liver disease model, linking it to lipid-related metabolic stress.
How did the EVOS M5000 help validate the in vitro fatty liver model? The EVOS M5000 provided fluorescence imaging and quantitative readouts of the bovine liver cell cultures, helping the authors monitor cellular changes in the fatty liver disease model.
Morphological and Molecular Characterization of Apple Scab (
2025 Current issues in molecular biology — Skin and Biomaterials
Apple scab, caused by the fungus
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Frequently asked questions about this study
What does this paper contribute to understanding apple scab? It presents a morphological and molecular characterization of the apple scab fungus, Venturia inaequalis, advancing knowledge of the pathogen's structure and biology.
How did the EVOS M5000 aid the morphological characterization? The EVOS M5000 supplied high-quality fluorescence and brightfield images of fungal structures, supporting the detailed morphological description of the apple scab pathogen.
<i>Mentha rotundifolia</i>, a Source of Amoebicidal Agents Against <i>Naegleria fowleri</i>.
2025 International journal of molecular sciences — Imaging Methods
Current therapies for Primary Amoebic Meningoencephalitis (PAM) present several limitations; consequently, there is an urgent need to develop new therapeutic agents. In this regard, we undertook bioassay-guided isolation of
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Frequently asked questions about this study
What new therapeutic lead did the study identify for Naegleria fowleri? Bioassay-guided isolation identified compounds from Mentha rotundifolia with amoebicidal activity against the brain-eating amoeba Naegleria fowleri, a pathogen responsible for primary amoebic meningoencephalitis.
How did the EVOS M5000 help evaluate amoebicidal activity? The EVOS M5000 was used for fluorescence imaging of treated amoebae, giving the researchers a visual readout of compound-induced damage or death in Naegleria fowleri cultures.
Graphene oxide-microplastic hybrid showcase elicited discrepancy through intrinsic interaction mediated steatosis, and apoptosis in macrophages.
2026 Materials today. Bio — Toxicology and Environmental
The widespread natural abundance of microplastics (MP) has been recognized to pose significant global health concerns, particularly due to limited understanding of their biological interactions. With the uncontrolled increase in MP accumulation in the…
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Frequently asked questions about this study
What toxic interaction did the study find between graphene oxide and microplastics? A graphene oxide-microplastic hybrid induced steatosis and apoptosis in macrophages through intrinsic particle interactions, revealing a more severe cellular response than either material alone.
How did the EVOS M5000 reveal macrophage stress and death? Fluorescence imaging on the EVOS M5000 allowed the team to visualize lipid accumulation and apoptotic markers in macrophages, linking the hybrid particles to the observed toxic phenotypes.
Protocol for extraction and characterization of mouse brain-derived extracellular matrix for neuronal cell culture.
2025 STAR protocols — Neuroscience
Neuronal cell cultures are highly sensitive to their microenvironment, particularly the choice of coating substrate. Here, we present a protocol to isolate extracellular matrix (ECM) from mouse brain tissue, providing a native coating material that closely…
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Frequently asked questions about this study
What new protocol does this paper present? The authors describe a protocol to isolate extracellular matrix from mouse brain tissue and use it as a native coating substrate for neuronal cell cultures, better mimicking the natural brain microenvironment.
How did the EVOS M5000 validate the brain-derived ECM coating? The EVOS M5000 was used to image neuronal cultures on the brain-derived ECM, helping confirm cell attachment, morphology, and overall culture health compared with standard substrates.
Filovirus infection disrupts epithelial barrier function and ion transport in human iPSC-derived gut organoids.
2025 PLoS pathogens — Infectious and Immunology
Gastrointestinal (GI) dysfunction, characterized by severe diarrhea and dehydration, is a central contributor to morbidity and mortality in filovirus disease in patients, yet the role of the epithelium in this clinical outcome remains poorly defined. Here, we…
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Frequently asked questions about this study
What effect did filovirus infection have on gut organoids? Filovirus infection disrupted epithelial barrier function and ion transport in human iPSC-derived gut organoids, implicating epithelial dysfunction in the gastrointestinal symptoms of filovirus disease.
How did the EVOS M5000 help connect filovirus infection to barrier breakdown? The EVOS M5000 captured fluorescence images and structural readouts of the infected organoids, revealing the epithelial damage and barrier disruption caused by filovirus infection.
Integrated In Silico and In Vitro Study of Copper Nanocatalyzed Carbonyl-Functionalized Triazoles-Inducing S Phase Cell Cycle Arrest and Apoptosis in MCF-7.
2026 ChemistryOpen — Cell Biology
The demand for novel, selective anticancer agents, driven by drug resistance and systemic toxicity of current treatments, underscores the importance of targeted drug discovery. Present research involved cytotoxic screening of a series of synthesized copper…
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Frequently asked questions about this study
What anti-cancer mechanism did the copper-triazole compounds show? The synthesized copper nanocatalyzed carbonyl-functionalized triazoles induced S phase cell cycle arrest and apoptosis in MCF-7 breast cancer cells, demonstrating selective cytotoxic activity.
How did the EVOS M5000 confirm cell cycle arrest and apoptosis? Fluorescence imaging on the EVOS M5000 provided visual evidence of nuclear morphology, cell cycle distribution, and apoptotic markers in the MCF-7 cells after compound treatment.
Antagonistic Mechanisms of Probiotic Aliivibrio sp. Strain Vl2 Against Moritella viscosa: Evidence from Co-cultivation and Targeted Transcriptomic Analysis.
2026 Probiotics and antimicrobial proteins — Infectious and Immunology
Winter ulcers, primarily caused by Moritella viscosa, represent a significant challenge for the Norwegian aquaculture industry. Effective control measures are hampered by the lack of effective vaccines and limited use of antibiotics, driven by the global…
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Frequently asked questions about this study
What protective mechanism did the probiotic Aliivibrio sp. Vl2 show against Moritella viscosa? Aliivibrio sp. strain Vl2 antagonized Moritella viscosa, the causative agent of winter ulcers in farmed fish, through co-cultivation competition and targeted transcriptomic responses that revealed probiotic defence mechanisms.
How did the EVOS M5000 help assess the probiotic-bacterial interaction? The EVOS M5000 captured fluorescence images of the co-cultures, allowing the researchers to visualize bacterial growth, attachment, and antagonistic effects between the probiotic and the pathogen.