EVOS M5000 in Skin, Wound, and Biomaterials Research
Curated literature review of peer-reviewed studies that used the EVOS M5000 Imaging System. Each paper is summarised by cell type, imaging technique, and disease area, with links to Google Scholar and PubMed. Plankton & Zoom does not host paywalled content.
Skin and wound-healing research often combines ex vivo tissue models, live-cell cytotoxicity assays, and novel optical materials. The EVOS M5000 provides the brightfield and fluorescence imaging backbone for these studies.
Cephalopod-inspired optical engineering of human cells.
Cell type: Human cells / tissues
Imaging technique: Optical / fluorescence microscopy
Disease area: Biomaterials / wound
Although many animals have evolved intrinsic transparency for the purpose of concealment, the development of dynamic, that is, controllable and reversible, transparency for living human cells and tissues has remained elusive to date. Here, by drawing inspiration from the structur...
Nat Commun — PMID 32488070
Google Scholar | PubMed | DOI
Polyvinylidene fluoride-Hyaluronic acid wound dressing comprised of ionic liquids for controlled drug delivery and dual therapeutic behavior.
Cell type: Human skin cells / fibroblasts
Imaging technique: Live-cell / fluorescence cytotoxicity imaging
Disease area: Wound healing
To improve the efficacy of transdermal drug delivery systems, the physical and chemical properties of drugs need to be optimized to better penetrate into the stratum corneum and to better diffuse into the epidermis and dermis layers. Accordingly, dual-biological function ionic li...
Acta Biomater — PMID 31586728
Google Scholar | PubMed | DOI
Human skin explant model for the investigation of topical therapeutics.
Cell type: Human skin explants (keratinocytes, fibroblasts)
Imaging technique: Histology / fluorescence imaging
Disease area: Skin disease / topical therapeutics
The development of in vitro and ex vivo models to mimic human illness is important not only for scientific understanding and investigating therapeutic approaches but also to mitigate animal testing and bridge the inter-species translational gap. While in vitro models can facilita...
Sci Rep — PMID 33273665
Google Scholar | PubMed | DOI
High frequency acoustic cell stimulation promotes exosome generation regulated by a calcium-dependent mechanism.
Cell type: Cultured cells (exosome production)
Imaging technique: Exosome imaging / fluorescence
Disease area: Diagnostics / drug delivery
Exosomes are promising disease diagnostic markers and drug delivery vehicles, although their use in practice is limited by insufficient homogeneous quantities that can be produced. We reveal that exposing cells to high frequency acoustic irradiation stimulates their generation wi...
Commun Biol — PMID 33020585
Google Scholar | PubMed | DOI