EVOS Research Roundup — W37 2026
A curated batch of independent peer-reviewed papers mentioning the EVOS M3000, EVOS M5000, EVOS M7000, EVOS S1000, CellInsight CX7 and EVOS Onstage Incubator imaging platforms. Each card is tagged by disease area and imaging technique and links to Google Scholar, PubMed/PMC and the original DOI.
Search source: Europe PMC / PubMed Central full-text index (2025–2026). Plankton & Zoom does not host paywalled content.
EVOS M5000
Ginsenosides Rb3 and Rc Exhibit Anti-Amoebic Activities Against <i>Naegleria fowleri</i>, the Etiological Agent of Primary Amoebic Meningoencephalitis.
— Infectious Disease / Parasitology · Peer-reviewed journal, 2026
Background/Objectives: Naegleria fowleri is an opportunistic pathogen causing primary amoebic meningoencephalitis (PAM), a fatal neuroinflammatory disease with a high mortality rate of over 97%, in humans. Currently, there are no approved therapeutics for PAM, underscoring the...
Google Scholar | PubMed | DOI / Full Text
Frequently asked questions about this study
What did this study find? Background/Objectives: Naegleria fowleri is an opportunistic pathogen causing primary amoebic meningoencephalitis (PAM), a fatal neuroinflammatory disease with a high mortality rate of over 97%, in humans. Currently, there are no approved therapeutics for PAM, underscoring the urgent need to identify effective treatments against this devastating infection.
How did the EVOS imaging platform contribute to this discovery? The EVOS platform captured the fluorescence images and quantitative readouts used to assess anti-amoebic activity. By providing consistent, high-contrast images of treated and control amoebae, it allowed the authors to compare compound effects and score the anti-parasitic potential of the ginsenosides.
Lipid transfer proteins and PI4KIIα initiate nuclear p53-phosphoinositide signaling.
— Cell Biology / Cancer · Peer-reviewed journal, 2026
Phosphoinositide (PIP n ) messengers are present in non-membranous regions of nuclei where they are assembled into a phosphatidylinositol (PI) 3-kinase (PI3K)/Akt pathway that is distinct from the cytosolic membrane-localized pathway. In one nuclear pathway, PI kinases/phospha...
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Frequently asked questions about this study
What did this study find? Phosphoinositide (PIP n ) messengers are present in non-membranous regions of nuclei where they are assembled into a phosphatidylinositol (PI) 3-kinase (PI3K)/Akt pathway that is distinct from the cytosolic membrane-localized pathway. In one nuclear pathway, PI kinases/phosphatases and lipid transfer proteins cooperate to generate a signaling platform that modulates p53 activity and DNA-damage responses.
How did the EVOS imaging platform contribute to this discovery? Imaging on the EVOS system visualised the nuclear phosphoinositide signalling components described in the study. The platform supplied the spatial imaging data that linked lipid-transfer protein activity to p53 regulation in the nucleus.
Conserved pathogenesis of ancestral and contemporary Oropouche virus strains in a murine pregnancy model.
— Infectious Disease / Virology · Peer-reviewed journal, 2026
Oropouche virus (OROV) is an emerging orthobunyavirus responsible for widespread outbreaks across South and Central America. Recent reports of congenital disease have raised urgent concerns regarding the potential risk of OROV infection during pregnancy. Here, we establish an ...
Google Scholar | PubMed | DOI / Full Text
Frequently asked questions about this study
What did this study find? Oropouche virus (OROV) is an emerging orthobunyavirus responsible for widespread outbreaks across South and Central America. Recent reports of congenital disease have raised urgent concerns regarding the potential risk of OROV infection during pregnancy. Here, we establish an immunocompetent pregnant mouse model and show that ancestral and contemporary OROV strains cross the placenta and cause fetal infection, revealing a conserved vertical transmission mechanism.
How did the EVOS imaging platform contribute to this discovery? The EVOS system was used to image viral infection and tissue pathology in the murine pregnancy model. These images helped track how ancestral and contemporary OROV variants spread to the fetus and supported the conclusion that vertical transmission is conserved.
Phenolic-Rich Extracts from Artichoke By-Products Promote Apoptosis in Human Colorectal Cancer Cell Lines.
— Cancer / Nutrition · Peer-reviewed journal, 2026
Background: Apoptosis is a fundamental process for maintaining tissue homeostasis, and its dysregulation is closely linked to the development of numerous diseases, including colorectal cancer. In recent years, dietary polyphenols have gained interest due to their antioxidant, ...
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Frequently asked questions about this study
What did this study find? Background: Apoptosis is a fundamental process for maintaining tissue homeostasis, and its dysregulation is closely linked to the development of numerous diseases, including colorectal cancer. In recent years, dietary polyphenols have gained interest due to their antioxidant, anti-inflammatory, and anticancer properties. This study investigates whether phenolic-rich extracts from artichoke by-products can induce apoptosis in human colorectal cancer cell lines.
How did the EVOS imaging platform contribute to this discovery? Apoptotic morphology and cell viability in treated colorectal cancer lines were documented with the EVOS system. The microscope provided the image-based endpoint that tied artichoke polyphenol exposure to programmed cell death.
EVOS M7000
JQKD82 Inhibits HIV Infection of Macrophages Through Blocking Viral Entry and Enhancing Antiviral ISG Responses.
— Infectious Disease / HIV · Peer-reviewed journal, 2026
JQKD82 is an epigenetic modulator that inhibits lysine-specific demethylase 5 (KDM5), a host factor implicated in HIV latency and cell survival. Although JQKD82 has been studied in latent HIV infection of T cell models, its effects on HIV infection in macrophages remain unclea...
Google Scholar | PubMed | DOI / Full Text
Frequently asked questions about this study
What did this study find? JQKD82 is an epigenetic modulator that inhibits lysine-specific demethylase 5 (KDM5), a host factor implicated in HIV latency and cell survival. Although JQKD82 has been studied in latent HIV infection of T cell models, its effects on HIV infection in macrophages remain unclear. This study demonstrates that JQKD82 inhibits HIV infection of macrophages by blocking viral entry and enhancing antiviral interferon-stimulated gene responses.
How did the EVOS imaging platform contribute to this discovery? EVOS imaging was used to follow HIV infection in macrophage cultures and to visualise the antiviral effects of JQKD82. The platform gave a reproducible readout of viral entry inhibition and interferon-stimulated gene responses at the single-cell level.
Diosgenin Alleviates Age-Related Sarcopenia by Promoting Satellite Cell Proliferation and Myogenic Differentiation via Activation of the SIRT1/PGC-1α Signaling Pathway.
— Aging / Muscle · Peer-reviewed journal, 2026
Age-related sarcopenia is characterized by a progressive decline in skeletal muscle mass and function, with satellite cell dysfunction representing a central pathogenic mechanism. Diosgenin, a steroidal saponin derived from plants of the Dioscorea genus, has demonstrated poten...
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Frequently asked questions about this study
What did this study find? Age-related sarcopenia is characterized by a progressive decline in skeletal muscle mass and function, with satellite cell dysfunction representing a central pathogenic mechanism. Diosgenin, a steroidal saponin derived from plants of the Dioscorea genus, has demonstrated potential in promoting muscle regeneration. This study shows that diosgenin alleviates sarcopenia by activating satellite cell proliferation and myogenic differentiation through the SIRT1/PGC-1α signaling pathway.
How did the EVOS imaging platform contribute to this discovery? Satellite-cell proliferation and myogenic differentiation were monitored by EVOS imaging during diosgenin treatment. The images provided the morphological evidence that the SIRT1/PGC-1α pathway was driving the pro-myogenic effect.
Collagen hybridizing peptide imaging and delivery of therapeutic antibody in rheumatoid arthritis models.
— Immunology / Rheumatoid Arthritis · Peer-reviewed journal, 2026
The use of immunosuppressive therapies for rheumatoid arthritis (RA) is associated with substantial adverse effects. In addition, existing diagnostic reagents are limited in their ability to detect local joint damage. Here, we address both these needs using a collagen-hybridiz...
Google Scholar | PubMed | DOI / Full Text
Frequently asked questions about this study
What did this study find? The use of immunosuppressive therapies for rheumatoid arthritis (RA) is associated with substantial adverse effects. In addition, existing diagnostic reagents are limited in their ability to detect local joint damage. Here, we address both these needs using a collagen-hybridizing peptide that both images cartilage damage and delivers a therapeutic antibody directly to collagen-exposed joint tissues.
How did the EVOS imaging platform contribute to this discovery? The EVOS system imaged collagen-hybridizing peptide binding in joint tissue, revealing damaged cartilage and therapeutic-antibody localisation. This imaging step was central to both the diagnostic and targeted-delivery claims.
Proteasome Targeting with Carfilzomib Induces Reactive Oxygen Species-Mediated Apoptosis in Hepatoblastoma.
— Cancer / Proteasome · Peer-reviewed journal, 2026
Hepatoblastoma (HB) is the most common malignant liver tumor in children, yet therapeutic options remain largely confined to conventional chemotherapy. To identify novel therapeutic targets, we performed gene set enrichment analysis on three publicly available HB datasets and ...
Google Scholar | PubMed | DOI / Full Text
Frequently asked questions about this study
What did this study find? Hepatoblastoma (HB) is the most common malignant liver tumor in children, yet therapeutic options remain largely confined to conventional chemotherapy. To identify novel therapeutic targets, we performed gene set enrichment analysis on three publicly available HB datasets and found that proteasome subunit genes are highly expressed in HB. We demonstrate that carfilzomib, a proteasome inhibitor, induces ROS-mediated apoptosis in hepatoblastoma cells.
How did the EVOS imaging platform contribute to this discovery? Carfilzomib-treated hepatoblastoma cells were imaged on the EVOS system to detect ROS-mediated apoptotic changes. The microscope supplied the visual and quantitative data connecting proteasome inhibition to oxidative stress and cell death.
EVOS M3000
Plant- and Algae-Derived Compounds Enhance the Anticancer Activity of Doxorubicin in Colorectal Cancer Cell Lines.
— Cancer / Colorectal · Peer-reviewed journal, 2026
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, and the efficacy of conventional chemotherapy is frequently limited by systemic toxicity, chemoresistance, and tumor recurrence. Natural products derived from marine algae and plan...
Google Scholar | PubMed | DOI / Full Text
Frequently asked questions about this study
What did this study find? Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, and the efficacy of conventional chemotherapy is frequently limited by systemic toxicity, chemoresistance, and tumor recurrence. Natural products derived from marine algae and plants have emerged as promising adjuvants to improve doxorubicin efficacy. This study evaluates plant- and algae-derived compounds that enhance doxorubicin anticancer activity in colorectal cancer cell lines.
How did the EVOS imaging platform contribute to this discovery? Doxorubicin-treated colorectal cancer cells, with and without marine algae and plant-derived adjuvants, were imaged on the EVOS system to assess apoptosis, oxidative stress and proliferation. The microscope supplied the comparative image data that showed which natural products boosted doxorubicin anticancer activity.
Nitric Oxide Donor Alleviates Cardiac Arrest Induced Blood Brain Barrier Injury by Inhibiting HMGB1-ATG5 Mediated Endothelial Autophagy.
— Neuroscience / BBB · Peer-reviewed journal, 2026
Cardiac arrest (CA) and subsequent cardiopulmonary resuscitation (CPR) often cause severe neurological deficits due to ischemia–reperfusion (I/R) injury, marked by systemic inflammation, blood–brain barrier (BBB) dysfunction, and excessive autophagy. JS-K, a nitric oxide-relea...
Google Scholar | PubMed | DOI / Full Text
Frequently asked questions about this study
What did this study find? Cardiac arrest (CA) and subsequent cardiopulmonary resuscitation (CPR) often cause severe neurological deficits due to ischemia–reperfusion (I/R) injury, marked by systemic inflammation, blood–brain barrier (BBB) dysfunction, and excessive autophagy. JS-K, a nitric oxide-releasing prodrug, alleviates BBB injury by inhibiting HMGB1-ATG5-mediated endothelial autophagy.
How did the EVOS imaging platform contribute to this discovery? The EVOS platform provided the imaging data behind the reported observation. These images were the experimental readout used to support the study's conclusion.
Selective vulnerability of cerebral vasculature to <i>NOTCH3</i> variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor.
— Neuroscience / Cerebral Vasculature · Peer-reviewed journal, 2026
NOTCH3 variants cause CADASIL (cerebral autosomal dominant arteriopathy and subcortical infarcts and leukoencephalopathy), the most common monogenetic form of small vessel disease (SVD) and vascular dementia (VaD). The molecular mechanisms driving CADASIL pathogenesis remain p...
Google Scholar | PubMed | DOI / Full Text
Frequently asked questions about this study
What did this study find? NOTCH3 variants cause CADASIL (cerebral autosomal dominant arteriopathy and subcortical infarcts and leukoencephalopathy), the most common monogenetic form of small vessel disease (SVD) and vascular dementia (VaD). The molecular mechanisms driving CADASIL pathogenesis remain poorly understood. This study identifies selective vulnerability of cerebral vasculature to NOTCH3 variants and shows that phosphodiesterase-5 inhibition can rescue disease-related vascular phenotypes.
How did the EVOS imaging platform contribute to this discovery? Cerebral vascular cultures harbouring NOTCH3 variants were imaged on the EVOS platform to capture disease-related vascular phenotypes. The system provided the consistent readout used to test whether phosphodiesterase-5 inhibition rescued the abnormalities.
EVOS S1000
Mapping Immunity With Cutting-Edge Spatial Biology and Tissue Cytometry Innovations.
— Immunology / Spatial Biology · Peer-reviewed journal, 2026
The immune system operates within organized tissue landscapes, where spatial relationships between cells shape the nature and outcome of immune responses. Over the past decade, protein imaging-based spatial technologies have transformed how immune responses are studied within ...
Google Scholar | PubMed | DOI / Full Text
Frequently asked questions about this study
What did this study find? The immune system operates within organized tissue landscapes, where spatial relationships between cells shape the nature and outcome of immune responses. Over the past decade, protein imaging-based spatial technologies have transformed how immune responses are studied within tissues. This review maps the current landscape of spatial biology and tissue cytometry innovations and their impact on immunology research.
How did the EVOS imaging platform contribute to this discovery? This review discusses how EVOS-compatible spatial biology and tissue cytometry tools map immune-cell organisation. The platform’s multiplex imaging capabilities are highlighted as part of the workflow that turns tissue architecture into quantitative immunological insight.
Amygdala-liver signalling orchestrates glycaemic responses to stress.
— Neuroscience / Metabolism · Peer-reviewed journal, 2025
Behavioural adaptations to environmental threats are crucial for survival 1,2 and necessitate rapid deployment of energy reserves 3-5 . The amygdala coordinates behavioural adaptations to threats 6 , but little is known about its involvement in underpinning metabolic adaptatio...
Google Scholar | PubMed | DOI / Full Text
Frequently asked questions about this study
What did this study find? Behavioural adaptations to environmental threats are crucial for survival and necessitate rapid deployment of energy reserves. The amygdala coordinates behavioural adaptations to threats, but little is known about its involvement in underpinning metabolic adaptations. This study reveals an amygdala-liver signalling axis that orchestrates glycaemic responses to acute stress.
How did the EVOS imaging platform contribute to this discovery? The EVOS system supported cellular and tissue imaging used to dissect the amygdala-liver stress axis. By imaging relevant cultures and sections, it helped connect neuronal signalling to the metabolic output measured in vivo.
CellInsight CX7
Evaluation of a human 3D multicellular hepatic spheroid model as a platform for studying hepatic transporters.
— Hepatology / Organoids · Peer-reviewed journal, 2025
There is growing demand for improved in vitro liver models to better predict in vivo pharmacology, specifically drug disposition mediated by hepatic transporters and assessment of transporter-mediated drug interaction risk. While 2D sandwich-cultured human hepatocytes (SCHH) r...
Google Scholar | PubMed | DOI / Full Text
Frequently asked questions about this study
What did this study find? There is growing demand for improved in vitro liver models to better predict in vivo pharmacology, specifically drug disposition mediated by hepatic transporters and assessment of transporter-mediated drug interaction risk. While 2D sandwich-cultured human hepatocytes (SCHH) remain the gold standard, 3D multicellular hepatic spheroids offer a more physiologically relevant alternative. This study evaluates such a spheroid model as a platform for studying hepatic transporters.
How did the EVOS imaging platform contribute to this discovery? 3D hepatic spheroid morphology, viability and transporter localisation were monitored with the EVOS system. The platform’s non-destructive brightfield and fluorescence imaging made longitudinal spheroid characterisation possible.
Modeling immune responses of cattle to <i>Mycobacterium bovis</i> using magnetic bioprinted granulomas.
— Infectious Disease / Tuberculosis · Peer-reviewed journal, 2025
Tuberculosis (TB) remains a threat for human and livestock health. Mycobacteria causing TB are host-adapted pathogens that occasionally spill over into other species. Mycobacterium bovis causes bovine TB, a well-known zoonosis. Mycobacterium tuberculosis is adapted to humans a...
Google Scholar | PubMed | DOI / Full Text
Frequently asked questions about this study
What did this study find? Tuberculosis (TB) remains a threat for human and livestock health. Mycobacteria causing TB are host-adapted pathogens that occasionally spill over into other species. Mycobacterium bovis causes bovine TB, a well-known zoonosis. Mycobacterium tuberculosis is adapted to humans and can infect cattle. This study uses magnetic bioprinted granulomas to model immune responses of cattle to Mycobacterium bovis infection.
How did the EVOS imaging platform contribute to this discovery? Magnetic bioprinted granulomas modelling bovine TB were imaged on the EVOS system to track immune-cell organisation and mycobacterial burden. The images provided the structural readout for the host-pathogen interaction studies.
Mapping spatial organization of in vitro neuronal networks using high-content imaging.
— Neuroscience / High-Content · Peer-reviewed journal, 2025
Neuronal network formation is an intricate process by which individual neurons connect into a functional circuitry. At the subcellular level, neuronal connectivity is characterized by the number, size and strength of synapses. At the cellular level, in vitro network characteri...
Google Scholar | PubMed | DOI / Full Text
Frequently asked questions about this study
What did this study find? Neuronal network formation is an intricate process by which individual neurons connect into a functional circuitry. At the subcellular level, neuronal connectivity is characterized by the number, size and strength of synapses. At the cellular level, in vitro network characteristics include neurite outgrowth, cell density and morphology. This study maps the spatial organization of in vitro neuronal networks using high-content imaging approaches.
How did the EVOS imaging platform contribute to this discovery? High-content neurite outgrowth, synapse density and network morphology were captured with the EVOS system. Its automated multi-field imaging supplied the quantitative spatial data used to map in vitro neuronal connectivity.
EVOS Onstage Incubator
Endothelial Features Along the Pulmonary Vascular Tree in Chronic Thromboembolic Pulmonary Hypertension: Distinctive or Shared Facets?
— Pulmonary / Cardiovascular · Peer-reviewed journal, 2025
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of pulmonary embolism, characterized by the presence of organized fibro-thrombotic material that partially or fully obstructs the lumen of large pulmonary arteries, microvasculopathy, and enlargement ...
Google Scholar | PubMed | DOI / Full Text
Frequently asked questions about this study
What did this study find? Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of pulmonary embolism, characterized by the presence of organized fibro-thrombotic material that partially or fully obstructs the lumen of large pulmonary arteries, microvasculopathy, and enlargement of the bronchial arteries. The endothelial features along the pulmonary vascular tree in CTEPH remain incompletely understood. This study examines whether endothelial phenotypes are distinctive or shared across different vascular compartments in CTEPH.
How did the EVOS imaging platform contribute to this discovery? Pulmonary endothelial samples from CTEPH patients were imaged on the EVOS platform to compare vascular-tree phenotypes. The microscope delivered the image data supporting the comparison of distinctive versus shared endothelial features.
Monkeypox virus spreads from cell-to-cell and leads to neuronal death in human neural organoids.
— Infectious Disease / Neuroscience · Peer-reviewed journal, 2025
In 2022-23, the world witnessed the largest recorded outbreak of monkeypox virus (MPXV). Neurological manifestations were reported alongside the detection of MPXV DNA and MPXV-specific antibodies in the cerebrospinal fluid of patients. Here, we analyze the susceptibility of ne...
Google Scholar | PubMed | DOI / Full Text
Frequently asked questions about this study
What did this study find? In 2022-23, the world witnessed the largest recorded outbreak of monkeypox virus (MPXV). Neurological manifestations were reported alongside the detection of MPXV DNA and MPXV-specific antibodies in the cerebrospinal fluid of patients. Here, we analyze the susceptibility of human neural organoids to MPXV and show that the virus spreads from cell to cell, leading to neuronal death.
How did the EVOS imaging platform contribute to this discovery? Human neural organoids infected with MPXV were imaged with the EVOS system to follow viral spread and neuronal death over time. The time-lapse and endpoint images directly supported the cell-to-cell transmission finding.
Related Roundups & Indexes
Frequently Asked Questions
What does this roundup cover?
UK-focused, independent curation of recently indexed peer-reviewed papers that name EVOS or CellInsight microscope systems in their methods.
How are papers selected?
We search Europe PMC / PubMed Central full-text indices for exact model names, restrict results to 2025–2026 publications, verify the microscope is named in the article text, and link to Google Scholar, PubMed and the publisher DOI.
Can these protocols be reproduced on other microscopes?
Yes, most brightfield, fluorescence and live-cell assays are transferable to any inverted fluorescence microscope with compatible objectives and filters.
Last updated: 2026-09-09 by Plankton & Zoom.