EVOS M5000 in Neuroscience and Neurodegeneration Research
Curated literature review of peer-reviewed studies that used the EVOS M5000 Imaging System. Each paper is summarised by cell type, imaging technique, and disease area, with links to Google Scholar and PubMed. Plankton & Zoom does not host paywalled content.
Neuroscience labs need imaging platforms that can capture neuronal morphology, oxidative-stress markers, and blood-brain barrier behaviour over time. The EVOS M5000 supports these workflows with fluorescence and phase-contrast imaging in a compact benchtop format.
Alzheimer's amyloid ß heterogeneous species differentially affect brain endothelial cell viability, blood-brain barrier integrity, and angiogenesis.
Cell type: Brain endothelial cells
Imaging technique: Live-cell / fluorescence imaging (BBB integrity, angiogenesis)
Disease area: Alzheimer's disease
Impaired clearance in the Alzheimer's Disease (AD) brain is key in the formation of Aβ parenchymal plaques and cerebrovascular deposits known as cerebral amyloid angiopathy (CAA), present in >80% of AD patients and ~50% of non-AD elderly subjects. Aβ deposits are highly heterogen...
Aging Cell — PMID 33155752
Google Scholar | PubMed | DOI
TLR2 deficiency attenuated chronic intermittent hypoxia-induced neurocognitive deficits.
Cell type: Neurons / microglia
Imaging technique: Histology / fluorescence imaging
Disease area: Sleep apnea / cognitive deficits
Chronic intermittent hypoxia (CIH) is the main symptom of obstructive sleep apnea syndrome (OSAS) and causes neural damage and cognitive deficits via neuroinflammation. Toll-like receptors (TLRs), especially TLR2, play an important role in neuroinflammation. However, the mechanis...
Int Immunopharmacol — PMID 32058931
Google Scholar | PubMed | DOI
Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1a Signaling Pathways Mediated by the NAMPT-NAD Pathway.
Cell type: Neurons
Imaging technique: Fluorescence imaging (oxidative stress, apoptosis)
Disease area: Ischemic stroke
BACKGROUND: Cerebral ischemic stroke (CIS) is a common cerebrovascular disease whose main risks include necrosis, apoptosis, and cerebral infarction. But few therapeutic advances and prominent drugs seem to be of value for ischemic stroke in the clinic yet. In the previous study,...
Oxid Med Cell Longev — PMID 33149812
Google Scholar | PubMed | DOI
High-Performance Conducting Polymer Nanotube-based Liquid-Ion Gated Field-Effect Transistor Aptasensor for Dopamine Exocytosis.
Cell type: PC12 / neuronal cells
Imaging technique: Optical sensing / fluorescence (aptasensor)
Disease area: Neurological / dopamine detection
In this study, ultrasensitive and precise detection of a representative brain hormone, dopamine (DA), was demonstrated using functional conducting polymer nanotubes modified with aptamers. A high-performance aptasensor was composed of interdigitated microelectrodes (IMEs), carbox...
Sci Rep — PMID 32111933
Google Scholar | PubMed | DOI