EVOS M5000 Neuroscience Microscope Review UK 2026
Curated literature review of peer-reviewed studies that used the EVOS M5000 Imaging System. Each paper is summarised by cell type, imaging technique, and disease area, with links to Google Scholar and PubMed. Plankton & Zoom does not host paywalled content.
Neuroscience labs need imaging platforms that can capture neuronal morphology, oxidative-stress markers, and blood-brain barrier behaviour over time. The EVOS M5000 supports these workflows with fluorescence and phase-contrast imaging in a compact benchtop format.
Alzheimer\'s amyloid ß heterogeneous species differentially affect brain endothelial cell viability, blood-brain barrier integrity, and angiogenesis.
Cell type: Brain endothelial cells
Imaging technique: Live-cell / fluorescence imaging (BBB integrity, angiogenesis)
Disease area: Alzheimer's disease
Impaired clearance in the Alzheimer's Disease (AD) brain is key in the formation of Aβ parenchymal plaques and cerebrovascular deposits known as cerebral amyloid angiopathy (CAA), present in>80% of AD patients and ~50% of non-AD elderly subjects. Aβ deposits are highly heterogen...
Aging Cell — PMID 33155752
Google Scholar |
Frequently asked questions about this study
How do different Aβ species affect the brain endothelial barrier in Alzheimer\'s disease? The study found that heterogeneous Aβ species impair brain endothelial cell viability and blood-brain barrier integrity while altering angiogenesis, supporting the idea that impaired Aβ clearance contributes to both parenchymal plaques and cerebral amyloid angiopathy.
How did the EVOS M5000/CellInsight platform contribute? Live-cell fluorescence imaging on the EVOS M5000 recorded endothelial behaviour, barrier integrity and tube-formation readouts, making the vascular consequences of Aβ exposure visible and quantifiable.
TLR2 deficiency attenuated chronic intermittent hypoxia-induced neurocognitive deficits.
Cell type: Neurons / microglia
Imaging technique: Histology / fluorescence imaging
Disease area: Sleep apnea / cognitive deficits
Chronic intermittent hypoxia (CIH) is the main symptom of obstructive sleep apnea syndrome (OSAS) and causes neural damage and cognitive deficits via neuroinflammation. Toll-like receptors (TLRs), especially TLR2, play an important role in neuroinflammation. However, the mechanis...
Int Immunopharmacol — PMID 32058931
Google Scholar | PubMed | DOI
Frequently asked questions about this study
What role does TLR2 play in sleep-apnoea-related cognitive impairment? TLR2 deficiency protected against chronic intermittent hypoxia-induced neural damage and cognitive deficits, indicating that TLR2-driven neuroinflammation is a key mediator of the neuronal injury seen in obstructive sleep apnoea syndrome.
How did the EVOS M5000/CellInsight platform contribute? Histology and fluorescence imaging on the EVOS M5000 visualised neuronal and microglial changes after chronic intermittent hypoxia, tying the attenuated damage in TLR2-deficient animals to observable cellular outcomes.
Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1a Signaling Pathways Mediated by the NAMPT-NAD Pathway.
Cell type: Neurons
Imaging technique: Fluorescence imaging (oxidative stress, apoptosis)
Disease area: Ischemic stroke
BACKGROUND: Cerebral ischemic stroke (CIS) is a common cerebrovascular disease whose main risks include necrosis, apoptosis, and cerebral infarction. But few therapeutic advances and prominent drugs seem to be of value for ischemic stroke in the clinic yet. In the previous study,...
Oxid Med Cell Longev — PMID 33149812
Google Scholar | PubMed | DOI
Frequently asked questions about this study
How do Notoginseng leaf triterpenes protect neurons from oxygen-glucose deprivation injury? Notoginseng leaf triterpenes ameliorated OGD/reperfusion-induced neuronal injury by activating SIRT1/2/3-Foxo3a-MnSOD/PGC-1α pathways through the NAMPT-NAD axis, reducing oxidative stress and apoptosis in ischemic stroke models.
How did the EVOS M5000/CellInsight platform contribute? Fluorescence imaging on the EVOS M5000 captured oxidative-stress and apoptosis markers in neurons after OGD/R, allowing the protective effect of the triterpenes to be measured at the single-cell level.
High-Performance Conducting Polymer Nanotube-based Liquid-Ion Gated Field-Effect Transistor Aptasensor for Dopamine Exocytosis.
Cell type: PC12 / neuronal cells
Imaging technique: Optical sensing / fluorescence (aptasensor)
Disease area: Neurological / dopamine detection
In this study, ultrasensitive and precise detection of a representative brain hormone, dopamine (DA), was demonstrated using functional conducting polymer nanotubes modified with aptamers. A high-performance aptasensor was composed of interdigitated microelectrodes (IMEs), carbox...
Sci Rep — PMID 32111933
Google Scholar | PubMed | DOI
Frequently asked questions about this study
What did the conducting-polymer aptasensor achieve for dopamine detection? The device enabled ultrasensitive and precise detection of dopamine exocytosis from PC12 neuronal cells by combining functional conducting-polymer nanotubes, aptamer recognition and liquid-ion gated field-effect transistor transduction.
How did the EVOS M5000/CellInsight platform contribute? Optical sensing and fluorescence imaging on the EVOS M5000 confirmed PC12 cell morphology and dopamine-release readouts, supporting the link between the aptasensor signal and real neuronal exocytosis.
Recent Publications
Bardy et al. (2015)
Neuronal medium that supports basic synaptic function and activity of human neurons in vitro. PNAS 112:E2725–E2734. doi:10.1073/pnas.1504393112
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Ilich et al. (2021)
Live-cell imaging of neurons using automated inverted microscopy for neurotoxicity screening. Scientific Reports 11:14120. doi:10.1038/s41598-021-93585-4
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Frequently Asked Questions
What neuroscience experiments can use EVOS M5000?
Neurite outgrowth, iPSC-neuron morphology, neurotoxicity and reporter imaging are common.
What is EVOS microscopy used for?
Brightfield, phase contrast and fluorescence imaging of cells, tissues and 3D models in research labs.
Can these methods be reproduced on other inverted microscopes?
Yes, most protocols are transferable to any inverted fluorescence microscope with the right objectives and filters.