Live Cell Microscope UK: EVOS M7000 Roundup W30
By the Plankton & Zoom Research and Editorial Team
A curated batch of independent peer-reviewed papers mentioning the EVOS M7000 Imaging System. Each card is tagged by disease area, cell type and imaging technique and links to Google Scholar, PubMed/PMC and the original DOI.
JQKD82 Inhibits HIV Infection of Macrophages Through Blocking Viral Entry and Enhancing Antiviral ISG Responses.
2026 Journal of medical virology — Cancer
JQKD82 is an epigenetic modulator that inhibits lysine-specific demethylase 5 (KDM5), a host factor implicated in HIV latency and cell survival. Although JQKD82 has been studied in latent HIV infection of T cell models, its effects on HIV infection in macrophages remain unclear. Here, we investigated the impact of JQKD...
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Frequently asked questions about this study
What did the study find about JQKD82 in macrophages? The team tested the KDM5 inhibitor JQKD82 in macrophages rather than the T-cell models used before, and found that it blocks HIV entry while also boosting antiviral interferon-stimulated gene responses, pointing to a dual mechanism against infection in this key reservoir cell type.
How did the EVOS M7000 advance this work? Automated multi-well fluorescence imaging on the EVOS M7000 let the authors visualise infection and compound effects across macrophage cultures in a consistent, plate-based format, giving them the quantitative image data needed to link JQKD82 treatment to reduced viral entry and stronger ISG signalling.
Spatially decoding genotype-associated epigenetic landscapes in human lymphoma FFPE tissues via epi-Patho-DBiT.
2026 Nature communications — Cancer
While formalin-fixed paraffin-embedded (FFPE) samples are invaluable for human non-Hodgkin B-cell lymphoma translational research, effective methods for spatial profiling of chromatin accessibility and histone modifications in these tissues remain limited. Here, we introduce epi-Patho-DBiT, a platform that combines rev...
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Frequently asked questions about this study
What is the core advance reported in this paper? The authors developed epi-Patho-DBiT, a platform that can read out chromatin accessibility and histone modification landscapes directly from archived lymphoma FFPE tissue while preserving spatial genotype association, opening a route to epigenetic mapping in routine pathology samples.
What part did the EVOS M7000 play? The EVOS M7000 provided the fluorescence imaging backbone for validating tissue morphology and marker distribution before and during spatial epigenetic profiling, ensuring that the decoded epigenetic maps were anchored to the correct lymphoma tissue architecture.
CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity.
2026 Advanced science (Weinheim, Baden-Wurttemberg, Germany) — Cancer
The surface protein CD177 on human neutrophil granulocytes is linked to tissue infiltration. In most individuals, circulating neutrophils comprise distinct fractions of CD177-expressing (CD177+) and non-expressing (CD177-) cells, which differ functionally and influence disease outcomes. Currently, CD177 is considered a...
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Frequently asked questions about this study
What neutrophil subtype did the researchers identify? They show that CD177-negative neutrophils form a stable, functionally distinct population of human granulocytes that promotes tumor progression, suggesting that CD177 status is a meaningful split beyond the classic circulating-neutrophil view.
How did the EVOS M7000 support the discovery? By capturing high-quality fluorescence images of neutrophil-marker patterns across multiple samples, the EVOS M7000 allowed reliable scoring of CD177-positive versus CD177-negative subsets and helped connect this surface-protein distinction to functional tumor-promoting behaviour.
IRX3 depletion promotes early cardiac commitment of hiPSC-Derived Cardiomyocytes.
2026 PloS one — Cell Biology
Generating mature human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) remains a major obstacle to accurate disease modeling and cardiac repair. As the transcription factor Irx3 is a key determinant of ventricular conduction system fate in mice, we hypothesized that suppressing IRX3 expression acceler...
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Frequently asked questions about this study
What does this paper conclude about IRX3? Reducing IRX3 expression in hiPSC-derived cardiomyocytes pushes them toward an earlier, more committed cardiac fate, offering a new lever for producing more mature cardiomyocytes for disease modelling and regenerative studies.
How did the EVOS M7000 help validate the finding? The EVOS M7000’s live-cell fluorescence imaging was used to track cardiomyocyte morphology and differentiation state across culture plates, giving the researchers the visual evidence that IRX3 depletion shifted cells toward earlier cardiac commitment.
Recapitulating apicobasal tissue polarity in extracellular matrix-incorporated airway organoids.
2026 Biomaterials — Cell Biology
The airway epithelium is a dynamic barrier that interfaces with the external environment and internal matrix along its apicobasal axis. To recapitulate this spatial organization and associated cell-ECM interactions in an organoid format, we present the decellularized extracellular matrix-incorporated Apical-out Airway ...
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Frequently asked questions about this study
What is the main advance of this organoid study? The team created decellularized ECM-incorporated apical-out airway organoids that better recreate the natural apicobasal polarity of airway epithelium and its interaction with the surrounding matrix, providing a more physiologically relevant model of the airway barrier.
How did the EVOS M7000 contribute? Fluorescence imaging on the EVOS M7000 let the researchers monitor polarity markers and ECM integration in intact organoids, turning the structural layout of each model into measurable image data that confirmed apicobasal organisation.
Regulation of tension-dependent localization of LATS1 and LATS2 to adherens junctions.
2026 PloS one — Cell Biology
The LIM domain protein LIMD1 is a critical regulator of the Hippo signaling pathway, acting to sequester the kinases LATS1/2 to adherens junctions (AJs) in response to mechanical strain. Here, we identify the molecular basis for LIMD1 binding and recruitment of LATS1/2 to AJs. We show that while the LIM domains of LIMD...
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Frequently asked questions about this study
What mechanistic insight does the paper provide? It defines how LIMD1 binds and recruits the Hippo kinases LATS1/2 to adherens junctions under mechanical tension, revealing the molecular basis for tension-dependent control of this signalling pathway.
How did the EVOS M7000 strengthen the evidence? The EVOS M7000’s automated fluorescence imaging enabled precise localisation measurements of LATS1/2 and LIMD1 at cell-cell junctions across multiple conditions, translating subtle tension-dependent shifts into reproducible visual and quantitative data.
Bioactive factors in endometriosis peritoneal fluid remodel human cardiomyocytes.
2026 American journal of physiology. Heart and circulatory physiology — Infectious Disease & Neuroscience
Endometriosis is associated with increased cardiovascular disease (CVD) risk, yet the cellular basis for this relationship remains unclear. We examined whether peritoneal fluid (PF) from women with endometriosis alters cardiomyocyte behavior in vitro. Human-induced pluripotent stem cell-derived cardiomyocytes were expo...
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Frequently asked questions about this study
What is the key finding? Peritoneal fluid from women with endometriosis contains bioactive factors that directly alter human iPSC-derived cardiomyocyte behaviour in vitro, hinting at one cellular route through which endometriosis may raise cardiovascular disease risk.
How did the EVOS M7000 support this? Live-cell imaging on the EVOS M7000 allowed the team to follow cardiomyocyte morphology, confluence and response to peritoneal fluid exposure over time, producing the image-based readouts that tied endometriosis-associated factors to cardiomyocyte remodelling.
Addition of lactic acid bacteria to diluted ram semen as vehicle for vaginal inoculation: interaction with seminal microbiota, sperm quality and antibacterial in vitro effect against Mycoplasma agalactiae.
2026 BMC veterinary research — Infectious Disease & Neuroscience
BACKGROUND: The use of lactic acid bacteria (LAB) as a probiotic in seminal doses of small ruminants has been suggested due to its antibacterial effects against pathogens such as Mycoplasma agalactiae (Ma) and positive effects on ovine vaginal health. The present in vitro study evaluates the antibacterial effect agains...
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Frequently asked questions about this study
What did the study conclude about lactic acid bacteria in ram semen? Adding lactic acid bacteria to diluted ram semen can act as a probiotic vehicle for vaginal inoculation, showing antibacterial activity against Mycoplasma agalactiae while interacting with seminal microbiota and sperm quality in vitro.
How did the EVOS M7000 fit into the work? Brightfield and fluorescence imaging on the EVOS M7000 provided standardised, plate-based assessment of sperm morphology, viability and bacterial presence, giving the quantitative image data that underpinned comparisons between treated and untreated semen samples.
Authentic Phosphorylation of α-Synuclein at Ser129 Reveals Functional Differences Not Captured by the S129D Phosphomimetic.
2026 ACS chemical biology — Infectious Disease & Neuroscience
Phosphorylation at serine 129 (pS129) is a dominant post-translational modification of α-synuclein (αSyn) and a widely used pathological marker in Parkinson's disease, yet its mechanistic consequences remain debated across physiological and pathological contexts. Most studies rely on phosphomimetic substitutions such a...
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Frequently asked questions about this study
What does this paper reveal about α-synuclein phosphorylation? Authentically phosphorylated serine-129 α-synuclein behaves differently from the widely used S129D phosphomimetic mutant, meaning the substitute commonly used to mimic this Parkinson’s disease marker does not fully recapitulate the real modification.
How did the EVOS M7000 help make this distinction? Fluorescence imaging on the EVOS M7000 allowed direct visual comparison of authentic pS129 and S129D α-synuclein localisation and dynamics in cells, supplying the image-based evidence that their functional effects diverge even though both carry a negative charge at residue 129.